Flavonoids may increase semen quality in infertile men with oligospermia?

Lara, Luana Venturin; Pasqualotto, Eleonora Bedin; Borges, Eduardo D.; Braga, D.P.A.F.; Salvador, Mirian; Pasqualotto, Fábio Firmbach

doi:10.1016/j.fertnstert.2008.07.675

Cited by 6 publications

(3 citation statements)

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“…The phytochemical analysis revealed the presence of abundant flavonoids, and these phytochemicals are reported as possessing antioxidant properties that could be beneficial in toxic conditions such as those induced by formalin [35][36][37]. This explains why in groups that received formalin there was marked decrease in the levels of the gonadotropins.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative and fecundity potentials of aqueous extract of Azanza garckeana (T. Hoffm) fruit pulp in formalin-induced toxicity on male albino mice

Bukar¹,

Tsokwa²,

Orshi³

2021

J. Pharm Bio.

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The study investigated the ameliorative and fecundity potentials of Azanza garckeana on formalin-induced toxicity in mice testes. Male albino mice were divided into eight groups of five mice each. Group I was administered normal saline (1 ml/kg per oral); Group II received formalin (10 mg/kg) alone; Groups III, IV and V received formalin (10 mg/kg IP) plus extract (orally) at 125, 250 and 500 mg/kg respectively for 40 days; Groups VI, VII and VIII received extract alone at 125, 250 and 500 mg/kg respectively. Gonadotropin assays and sperm analysis were carried out using standard methods. Animals in groups III to VIII showed significant body weight increase compared to baseline value (p<0.05) from day 20 to 40. Co-administration of the extract at 250 and 500 mg/kg with formalin caused a significant increase in weight of the epididymis compared to control (p<0.05). Extract at 125 and 500 mg/kg induced significant increase in LH, FSH and testosterone compared to control (p<0.05). Extract alone at 250 and 500 mg/kg caused significant increase in FSH compared with control (p<0.05). Extract at 250 mg/kg demonstrated highest fecundity potential of 8.49. These results imply that Azanza garckeana possesses ameliorative and pro-fertility properties. Keywords: Azanza garckeana; Gonadotropins; Aphrodisia; Fecundity; Gonadosomatic index; Sperm Motility

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Section: Discussionmentioning

confidence: 99%

Ameliorative and fecundity potentials of aqueous extract of Azanza garckeana (T. Hoffm) fruit pulp in formalin-induced toxicity on male albino mice

Bukar¹,

Tsokwa²,

Orshi³

2021

J. Pharm Bio.

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“…The effects of carotenoids in men with oligozoospermia, asthenozoospermia, teratozoospermia and higher baseline concentrations of sperm have also shown benefits such as increase in pregnancy rates and rise in sperm concentration (Gupta & Kumar, 2002). Similarly, in men with oligospermia, phytonutrient supplementation resulted in higher levels of SOD, catalase and lipid peroxidation in sperm (Lara et al, 2008). A study evaluated 20 infertile men with asthenoteratozoospermia who were treated with the following oral antioxidants for 3 months: L-carnitine 1,500 mg, vitamin C 60 mg, coenzyme Q10 20 mg, vitamin E 10 mg, zinc 10 mg, vitamin B9 200 ug, selenium 50 ug and vitamin B12 1 g. The authors measured SDF during separate time intervals (0, 2, 6, 8, and 24 hr) at 37°C before and after antioxidant supplementation.…”

Section: Ta B L E 2 Combination Antioxidant Therapy For Male Infertilitymentioning

confidence: 99%

Are antioxidants a viable treatment option for male infertility?

2020

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Oxidative stress is caused by an imbalance between ROS and antioxidants, which plays a significant role in the pathophysiology of many human diseases. There is extensive evidence highlighting the role of oxidative stress in male infertility due to elevated levels of sperm DNA fragmentation and abnormal semen parameters. The use How to cite this article: Ali M, Martinez M, Parekh N. Are antioxidants a viable treatment option for male infertility?

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“…Exposure to acetaldehyde produced from alcohol metabolism in mice interferes with the whole process of sperm formation in the seminiferous tubules, reducing sperm quality (Akang et al, 2011), and decreases the amount of testosterone secreted, leading to failure in the formation and release of spermatids from Sertoli cells. As a result, the concentration of sperm cells in the Sertoli cells increases, stimulating an autoimmune process and phagocytosis of sperm cells that eventually lower the number of mature sperm cells (Malini, 2013 It is known that flavonoids can increase sperm count by repairing the sperm plasma membrane (Jamalan et al, 2015) and activation of the enzymes catalase and superoxidase dismutase (SOD) (Lara, 2008). Catalase and SOD are types of enzymatic antioxidants that function to protect cell membranes against free radicals.…”

Section: Sperm Count On Micementioning

confidence: 99%

The Effect of Coffee Fruit Skin Extract on Sperm Characteristics And Testicular of Mice With Ethanol-Induced

et al. 2020

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Coffee fruit skin contains antioxidant compounds that can repair damaged tissues, especially those of reproductive or-gans. This study was designed to assess to what extent the metha-nolic extract of coffee fruit skin affected sperm characteristics and testicular histology in mice receiving 15% ethanol for 15 days. It used 25 male mice aged four months and employed a completely randomized design with two controls (K) and three treatments (P), namely K1 (without ethanol), K2 (15% ethanol), P1 (15% ethanol and the methanolic extract of coffee fruit skin, or MECS, at 125 mg/ kg BW), P2 (15% ethanol and MECS 250 mg/kg BW), and P3 (15% ethanol and MECS 500 mg/kg BW). These treatments were administered orally with a 1 mL disposable syringe for 15 days. The parameters observed were sperm characteristics (viability, morphology, and sperm count) and the microscopic structure of the testicles (lu-men area, diameter, and area of seminiferous tubules). These data were then analyzed using the one-way ANOVA, continued with the LSD and Duncan’s tests (P <0.05). The results showed that P2 (250 mg/kg BW) substantially improved sperm count (86.5x105±1.73 cells/ mL), sperm viability (87.26±0.05%), and the proportion of normal sperm morphology (93.33±0.004%) of mice with 15% ethanol-in-duced sperm damages. Testicular histology also confirmed improve-ments in spermatogenic cells, as evident from the lumen, diameter, and area seminiferous tubules after receiving P1 and P2. In conclu-sion, the optimum dose of the coffee skin extract for improving sperm quality and microscopic structures of mice testicles is 250 mg/kg BW.

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Flavonoids may increase semen quality in infertile men with oligospermia?

Cited by 6 publications

References 0 publications

Ameliorative and fecundity potentials of aqueous extract of Azanza garckeana (T. Hoffm) fruit pulp in formalin-induced toxicity on male albino mice

Ameliorative and fecundity potentials of aqueous extract of Azanza garckeana (T. Hoffm) fruit pulp in formalin-induced toxicity on male albino mice

Are antioxidants a viable treatment option for male infertility?

The Effect of Coffee Fruit Skin Extract on Sperm Characteristics And Testicular of Mice With Ethanol-Induced

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