Flavonoids in root bark of Pongamia pinnata

Tanaka, Toŝhiyuki; Iinuma, Munekazu; Yuki, Kaoru; Fujii, Yuko; Mizuno, Mizuo

doi:10.1016/0031-9422(92)80055-j

Cited by 88 publications

(39 citation statements)

References 10 publications

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“…217 The structure of pongamol was established as the enol by X-ray crystallography. 218 Lanceolatin B was isolated from P. pinnata 219 and T. purpurea. 220 A new method for dipolar cycloaddition of diazocyclohexane-1,3-diones, leading to benzofuran derivatives has been applied to the tota1 synthesis of natural products from Tephrosia and Pongamia.…”

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Total synthesis of natural products containing benzofuran rings

et al. 2017

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Research on natural products containing benzofuran has remarkably increased during the past few decades.Newly isolated natural products with complex structures are being studied, characterized and screened for possible biological activities. Several of such compounds have exhibited various biological activities, thus their total syntheses have attracted much attention from synthetic organic chemists. In this review, we aim to highlight the origins, structures, biological potencies, and synthetic approaches of those natural products bearing at least one benzofuran in their complex structures. Furthermore, we especially focus on the step in which this key heterocycle is installed during the total synthesis of a natural product as the desired target.

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confidence: 99%

Total synthesis of natural products containing benzofuran rings

et al. 2017

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“…16,17) The long-range coupling between H-6 and H-4Љ (Jϭ0.9 Hz) were characteristically observed for other (2Љ,3Љ:7,8)-furanoflavones such as 4-6. 12,13) The (2Љ,3Љ:6,5)-furanoflavone structure is therefore unlikely for 1. In addition, in the HMBC spectrum (long-range delay of 62.5 ms corresponding to n J CH of 8 Hz) of 1 (Fig.…”

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confidence: 99%

Constituents of Pongamia pinnata Isolated in a Screening for Activity to Overcome Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Resistance

Minakawa

Toume

Ahmed

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2؆,3؆:7,8)-furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.

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“…Preliminary phytochemical analysis of the stem bark of Pongamia pinnata showed presence of alkaloids, glycosides, phenolic compounds, flavonoids, furanoflavones, chromenoflavones, flavonodiaketones, pongaflavonol, pyranochalcones, and flavonoid glycoside (Krishna & Grampurohit, 2006;Yin et al, 2006aYin et al, , 2006bYin et al, , 2005Carcache-Blanco et al, 2003;Asalkar et al, 2000;Tanaka et al, 1992;Pathak et al, 1983;Talapatra et al, 1982). The antihyperglycemic activity of PPSBAE may be due to the presence of several bioactive antidiabetic principles.…”

Section: Discussionmentioning

confidence: 99%

Antihyperglycemic Activity ofPongamia pinnataStem Bark in Diabetic Mice

Badole

Subhash

Bodhankar

2008

Pharmaceutical Biology

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Pongamia pinnata (L.) Pierre (Fabaceae), popularly known as "Karanj" or "Karanja" in Hindi, and Indian beech in English, is a medium-sized glabrous tree. In the present study we report the antihyperglycemic activity of stem bark of alcohol extract of Pongamia pinnata (PPSBAE). Based on acute oral toxicity data, PPSBAE showed no mortality in normal mice up to 5,000 mg/kg. PPSBAE was administered as three doses (i.e., 100, 200, and 400 mg/kg) to diabetic mice, and the serum glucose level and body weight were measured. The onset of serum glucose reduction was observed at 2 h (130.32 mg/dl), peak at 4 h (151.79 mg/dl) and sustained at 6 h, but waned at 24 h. In the subacute study, maximum reduction (305.72 mg/dl) in serum glucose was observed at a dose of 400 mg/kg on day 28. An oral glucose tolerance test (OGTT) was carried out after administration PPSBAE (200 mg/kg) in non-diabetic mice previously loaded with 2.5 g/kg, per oral (p.o.) of glucose. The PPS-BAE (200 mg/kg) showed increased glucose threshold in non-diabetic mice. These results suggest that the PPSBAE possesses antihyperglycemic activity.

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Flavonoids in root bark of Pongamia pinnata

Cited by 88 publications

References 10 publications

Total synthesis of natural products containing benzofuran rings

Total synthesis of natural products containing benzofuran rings

Constituents of Pongamia pinnata Isolated in a Screening for Activity to Overcome Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Resistance

Antihyperglycemic Activity ofPongamia pinnataStem Bark in Diabetic Mice

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