Flavonoids in modulation of cell survival signalling pathways

Mansuri, Mohammad Lukman; Parihar, Priyanka; Solanki, Isha; Parihar, Mordhwaj S.

doi:10.1007/s12263-014-0400-z

Cited by 146 publications

(104 citation statements)

References 71 publications

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“…The inhibition or stimulation of flavonoids on this pathway greatly influences the cell function by altering the phosphorylation of target molecules and modulating gene expression [15].…”

Section: Discussionmentioning

confidence: 99%

Antimutagenic Effects of Ethanol Extract of Syzygium Myrtifolium Walp. In Cyclophosphamide-Induced Mice

Lingga

Harahap

Yuandani

2018

Asian J Pharm Clin Res

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Objective: This current study was carried to evaluate the antimutagenic effects of ethanol extract Syzygium myrtifolium Walp. in cyclophosphamideinduced mice. Methods:The mice were divided into 6 groups with the total number of 30 mice (CMC Na 0,5%; cyclophosphamide 30 mg/kg bw; and extract 50, 100, 200, and 400 mg/kg bw) consisting of 5 rats for each group. All mice were induced by cyclophosphamide 30 mg/kg bw on day 1, then followed by administration of extract for 7 days. On day 8, the blood was collected to evaluate the hematocrit value, while the femoral bone marrow was collected to determine the number of micronucleus cells. Results:The ethanol extracts of S. Myrtifolium leaves at doses of 50-400 mg/kg bw demonstrated antimutagenic effect by inhibiting the formation of micronucleus as compared to negative control (CMC Na 0.5%). Meanwhile, the hematocrit value increased at dose of 100, 200, and 400 mg/kg bw as compared to negative control. Conclusion:This finding suggests that ethanol extract of S. myrtifolium has antimutagenic activity that may increase the normal cell number in cyclophosphamide-induced mice.

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“…The inhibition or stimulation of flavonoids on this pathway greatly influences the cell function by altering the phosphorylation of target molecules and modulating gene expression [15].…”

Section: Discussionmentioning

confidence: 99%

Antimutagenic Effects of Ethanol Extract of Syzygium Myrtifolium Walp. In Cyclophosphamide-Induced Mice

Lingga

Harahap

Yuandani

2018

Asian J Pharm Clin Res

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“…On the other hand, p38 is phosphorylated during inflammation, cell cycle, cell death, development, cell differentiation, senescence, and tumorigenesis. JNK is also activated during many cellular events, such as growth control, transformation, and apoptosis [43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of Peltophorum pterocarpum leaf extract against hydrogen peroxide induced oxidative stress and cytotoxicity

et al. 2017

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Background: Peltophorum pterocarpum is a plant from the family of Leguminosae and a tropical tree found in South East Asia region. The leaves of the plant is rich in anti-oxidant polyphenols. Traditionally this plant was used to cure intestinal disorders and as a relief for sprain, bruise, muscular pain and sores and for pain during child birth. Since oxidative stress is a major contributing factor towards neurodegenerative diseases the leaves of this plant was explored for its neuroprotective properties. Method: In this study, we report the neuroprotective properties of the ethanolic extract of Peltophorum pterocarpum leaf against oxidative stress induced cell death by H 2 O 2 , in an in vitro model of neuronally differentiated IMR32 neuroblastoma cells. Hydrogen peroxide was used as an inducer for oxidative stress. Cell viability was determined using MTT assay, apoptosis studies were carried out using Annexin V-FITC and Caspase 3 assays, mitochondrial membrane potential was examined using JC1 staining. The oxidative stress induced by H 2 O 2 was determined by quantifying the intracellular reactive oxygen species production using DCF-DA staining. Mitogen activated protein kinase signaling pathway of the neuroprotective effect of PTE was also elucidated since oxidative stress activates this pathway signaling.

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“…The flavonoids also stimulate signaling pathways required for various activities in the cells [56]. They have also been reported to modulate various transcription factors in different study systems [57].The organisms do not waste their energy in futile exercises and plants synthesize cardiac glycosides for defence since some of them are poisonous [58]. Digitalis is a cardiac glycoside that has been used to protect heart [58].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical and TLC Profiling of Oroxylum indicum and Milletia pachycarpa

M¹,

J²

2015

Saha, J Plant Biochem Physiol

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The humans have used medicinal plants for healthcare since the time immemorial. The systematic phytochemical analysis of traditionally used medicinal plants is needed to establish their use as medicine. Oroxylum indicum and Milletia pachycarpa have been used in India and China to treat various health related disorders. Therefore it was decided to undertake phytochemical and Thin Layer Chromatography (TLC) profiling of different extracts of Oroxylum indicum and Milletia pachycarpa using standard procedures. The dried powder of stem bark of Oroxylum indicum and root bark of Milletia pachycarpa was sequentially extracted in chloroform, ethanol and water. The dried extract of each plant was phytochemically analyzed for the presence of alkaloids, flavonoids, cardiac glycosides, phytosterols, saponins, tannins steroids and phlobatannins. Each extract from both plants was processed for TLC profiling on silica gel using various solvent combinations as mobile phase. The phytochemical analysis showed the presence of alkaloids in chloroform and ethanol extracts, whereas alkaloids were absent in aqueous extract of both Oroxylum indicum and Milletia pachycarpa. The flavonoids were observed in all extracts of both plants. However, cardiac glycosides were absent in the aqueous extract of Milletia pachycarpa. The saponins were detected in all the extracts of both plants except the chloroform extract of Oroxylum indicum. The tannins could not be detected in the aqueous extract of M. pachycarpa. The phlobatannins were absent in all extracts of both plants. Steroids exhibiting a wide variety of biological activity [8]. Almost every part of this tree possesses medicinal properties and has been used in several traditional Ayurvedic and folk medicines [18]. O. Indicum has been reported to possess several medicinal properties including analgesic, antibacterial, anti-inflammatory, anticancer, antioxidant [19][20][21][22][23]. Therefore, an attempt has been made to study the phytochemical constituents of Milletia pachycarpa and Oroxylum indicum. Materials and Methods Preparation of the extractThe non-infected stem bark of O. indicum was collected from Champhai whereas root bark of Milletia pachycarpa was collected from Kolasib district of Mizoram, India during the dry season in the month of January. The identification of plant was done by the Department of Horticulture and Aromatic and Medicinal Plants, Mizoram University, Aizawl, India. The barks of both plants was washed thoroughly with clean water and allowed to shade dry at room temperature in the dark in clean and hygienic conditions. The dried barks of both plants were separately powdered using an electrical grinder at room temperature. The powdered bark of O. indicum stem or root bark of M. pachycarpa was sequentially extracted with petroleum ether, chloroform, ethanol and distilled water according to increase in polarity using a Soxhlet apparatus until the solvents became colourless [24]. The liquid extracts were concentrated by evaporating their liquid contents using ...

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Flavonoids in modulation of cell survival signalling pathways

Cited by 146 publications

References 71 publications

Antimutagenic Effects of Ethanol Extract of Syzygium Myrtifolium Walp. In Cyclophosphamide-Induced Mice

Antimutagenic Effects of Ethanol Extract of Syzygium Myrtifolium Walp. In Cyclophosphamide-Induced Mice

Neuroprotective effects of Peltophorum pterocarpum leaf extract against hydrogen peroxide induced oxidative stress and cytotoxicity

Phytochemical and TLC Profiling of Oroxylum indicum and Milletia pachycarpa

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