Flavonoids in Cancer and Apoptosis

Abotaleb, Mariam; Samuel, Samson Mathews; Varghese, Elizabeth; Varghese, Sharon; Kubatka, Peter; Líšková, Alena; Büsselberg, Dietrich

doi:10.3390/cancers11010028

Cited by 534 publications

(434 citation statements)

References 274 publications

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“…Naringenin anticancer effect arrests cell development at the G0/G1 phase; inhibits Candida spp. growth [39,43,60] 18 Naringin anticancer effect arrests cell development at the G0/G1 phase; inhibits Candida spp. growth [39,43,60] 20 Luteolin anticancer associated with the induction of apoptosis, and inhibition of cell proliferation, metastasis and angiogenesis [60,86]…”

Section: Electrochemical Evaluation Of Antioxidant Capacitymentioning

confidence: 99%

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Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts

et al. 2019

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This study aimed to explore for the first time the biological properties such as antifungal, antitumoral and antioxidant of Danube Delta Nymphaea alba (N. alba) leaf and root methanolic extracts. The toxicity studies of N. alba extracts showed no inhibitory effect on wheat seed germination by evaluating the most sensitive physiological parameters (Germination %, Germination index, Vigor index) and using confocal laser scanning microscopy images. The analyzed extracts were found to have high antifungal activity against Candida glabrata with MIC values of 1.717 µg/mL for leaf and 1.935 µg/mL for root. The antitumor activity of the both extracts against A2780/A2780cisR ovarian, LNCaP prostate and MCF-7 breast cancer cells was promising with IC50 values ranging from 23–274 µg/mL for leaf and 18–152 µg/mL for root, and the combination of N. alba extracts with cisplatin showed a synergistic effect (coefficient of drug interaction <1). The antioxidant properties were assessed by β-carotene bleaching, ABTS and FRAP assays and cyclic voltammetry. Quercetin, the most prominent antioxidant, was quantified in very good yields by spectroelectrochemical assay.

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Section: Electrochemical Evaluation Of Antioxidant Capacitymentioning

confidence: 99%

“…Epicatechin anticancer activity [60,88] 25 Apigenin anticancer effect by arresting cell development at the G0/G1 phase; the inhibition of phosphorylation of mitogen-activated protein kinase (MAPK) [60] 26 Orientin antioxidant, antiviral and antibacterial activities, anti-inflammatory neuroprotective or antidepressant-like effects [89] 3. Materials and Methods…”

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confidence: 99%

Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts

et al. 2019

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“…Research on natural compounds as potential source of anti-cancer drugs is generating considerable interest to invest more in plant-based research. Mechanistic studies evaluating therapeutic potential of plant based compounds reveal multi targeted action on the target cell [164]. The principle behind any therapeutic approach against tumor growth is essentially by targeting the hallmarks of cancer, miRNA profiling of different cancers reveals a striking association of miRNA with all stages (cancer hallmarks) of the cancer progression.…”

Section: Discussion and Concluding Remarksmentioning

confidence: 99%

Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression

et al. 2020

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Several phytochemicals have been identified for their role in modifying miRNA regulating tumor progression. miRNAs modulate the expression of several oncogenes and tumor suppressor genes including the genes that regulate tumor angiogenesis. Hypoxia inducible factor-1 alpha (HIF-1α) signaling is a central axis that activates oncogenic signaling and acts as a metabolic switch in endothelial cell (EC) driven tumor angiogenesis. Tumor angiogenesis driven by metabolic reprogramming of EC is crucial for tumor progression and metastasis in many different cancers, including breast cancers, and has been linked to aberrant miRNA expression profiles. In the current article, we identify different miRNAs that regulate tumor angiogenesis in the context of oncogenic signaling and metabolic reprogramming in ECs and review how selected phytochemicals could modulate miRNA levels to induce an anti-angiogenic action in breast cancer. Studies involving genistein, epigallocatechin gallate (EGCG) and resveratrol demonstrate the regulation of miRNA-21, miRNA-221/222 and miRNA-27, which are prognostic markers in triple negative breast cancers (TNBCs). Modulating the metabolic pathway is a novel strategy for controlling tumor angiogenesis and tumor growth. Cardamonin, curcumin and resveratrol exhibit their anti-angiogenic property by targeting the miRNAs that regulate EC metabolism. Here we suggest that using phytochemicals to target miRNAs, which in turn suppresses tumor angiogenesis, should have the potential to inhibit tumor growth, progression, invasion and metastasis and may be developed into an effective therapeutic strategy for the treatment of many different cancers where tumor angiogenesis plays a significant role in tumor growth and progression.

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“…Jazzara et al [170] concluded that λ-carrageenan (sulfated galactans found in certain red seaweeds) could be a promising bioactive polymer, showed a remarkable inhibitory effect on MDA-MB-231(triple negative breast cancer cell line) cell migration [171]. Several studies support polyphenols [172][173][174][175][176], flavonoids [177][178][179][180][181][182][183][184][185][186], fucoidan [159,160,166,[187][188][189][190][191][192][193][194][195], lutein/zeaxanthin [196][197][198][199][200], other seaweed alkaloids, peptides, tannins and polysaccharides [132,164,[201][202][203][204][205][206][207][208][209][210] in breast cancer management. The number of deaths from colorectal cancer in Japan continues to increase [211], it is the third most common diagnosis and second deadliest malignancy for both sexes combined…”

Section: Cancer Prevention and Tumor Controlmentioning

confidence: 99%

Seaweeds: An Extensive Review of Medicinal Values

Mohiuddin¹

2019

APCT

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The global economic impact of the five leading chronic diseases-cancer, diabetes, mental illness, CVD, and respiratory disease-could reach $47 trillion over the next 20 years, according to a study by the World Economic Forum (WEF). According to the WHO, 80% of the world's population primarily those of developing countries rely on plant-derived medicines for the healthcare. The purported efficacies of seaweed derived phytochemicals showing great potential in obesity, T2DM, metabolic syndrome, CVD, IBD, sexual dysfunction and some cancers. Therefore, WHO, UN-FAO, UNICEF and governments have shown a growing interest in this unconventional food with health-promoting effects. Edible marine macro-algae (seaweed) are of interest because of their value in nutrition and medicine. Seaweeds contain several bioactive substances like polysaccharides, proteins, lipids, polyphenols, and pigments, all of which may have beneficial health properties. People consume seaweed as food in various forms: raw as salad and vegetable, pickle with sauce or with vinegar, relish or sweetened jellies and also cooked for vegetable soup. By cultivating seaweed, coastal people are getting an alternative livelihood as well as advancing their lives. In 2005, world seaweed production was totaled 14.7 million tons which more than double (30.4 million tons) in 2015. The present market value is nearly $6.5 billion and projected to reach some $9 billion seaweed global market by 2024. Aquaculture is recognized as the most sustainable means of seaweed production and accounts for approximately 27.3 million tons (more than 90%) of global seaweed production per annum. Asian countries produced 80% for world markets where China alone produces half of the total demand. The top six seaweed producing countries are China,

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Flavonoids in Cancer and Apoptosis

Cited by 534 publications

References 274 publications

Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts

Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts

Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression

Seaweeds: An Extensive Review of Medicinal Values

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