Flavonoids from Daphne aurantiaca and Their Inhibitory Activities against Nitric Oxide Production

Liang, Shuang; Tian, Jun‐Mian; Feng, Yi; Liu, Xiaohua; Zhi, Xiao‐Yang; Zhang, Wei‐Dong

doi:10.1248/cpb.59.653

Cited by 21 publications

(18 citation statements)

References 28 publications

(18 reference statements)

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“…glutinosa [33]. Liang et al [34] isolated sakuranetin from methanolic extract of powdered stem bark of Daphne aurantiaca, the common evergreen shrub native to Yunnan, and Sichuan provinces in China. As a result of the extraction of 6.5 kg of the powder and the subsequent chromatographic purification, 50 mg of pure sakuranetin was isolated.…”

Section: Sources Of Sakuranetinmentioning

confidence: 99%

A Review on Sources and Pharmacological Aspects of Sakuranetin

Stompor

2020

Nutrients

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Sakuranetin belongs to the group of methoxylated flavanones. It is widely distributed in Polyomnia fruticosa and rice, where it acts as a phytoalexin. Other natural sources of this compound are, among others, grass trees, shrubs, flowering plants, cheery, and some herbal drugs, where it has been found in the form of glycosides (mainly sakuranin). Sakuranetin has antiproliferative activity against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320). Moreover, sakuranetin shows antiviral activity towards human rhinovirus 3 and influenza B virus and was reported to have antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties. The aim of this review is to present the current status of knowledge of pro-health properties of sakuranetin.

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Section: Sources Of Sakuranetinmentioning

confidence: 99%

A Review on Sources and Pharmacological Aspects of Sakuranetin

Stompor

2020

Nutrients

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“…IC 50 values were calculated as the concentration (μg/mL) of samples causing 50% inhibition of cell viability. H NMR spectra data of 1 (Table 1) were very similar to those of daphnotin B, 16 except for appearance of an additional methylene at δ C 30.7 (C-8'') instead of an oxygenated methine, together with appearance of an additional methyl group (δ C 8.6, δ H 2.05), and a singlet aromatic proton δ H 6.62 (1H, s) in 1. In the HMBC spectrum, corrections from the singlet aromatic proton H-5 (δ H 6.62) to C-4 (δ C 33.8), C-9'' (δ C 25.7), and C-7 (153.3), and from the methyl singal at δ H 2.03 to C-7 (δ C 153.3), C-8 (δ C 113.0), and C-8a (δ C 152.0) indicated that the methyl group was located at C-8 and the singlet aromatic proton was assigned to C-5.…”

Section: Methodsmentioning

confidence: 68%

Two New Flavonoids from Dragon's Blood of Dracaena cambodiana

Mei¹,

Luo²,

Wang³

et al. 2013

Bulletin of the Korean Chemical Society

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Phytochemical investigation on dragon's blood of Dracaena cambodiana led to the discovery of two new flavonoid derivatives, cambodianin G (1) and cambodianin H (2). Their structures were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. The two compounds were observed to exhibit antibacterial activities against Staphylococcus aureus, and compound 1 showed cytotoxicities against K562 and SGC-7901 cell lines.

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“…Mostly, drugs act on this enzyme preferentially [144]. In another invention the therapeutic compounds like oleanolic acid (28), dihydromyricetin, epigallocatechin gallate, myricetin [145,146] and epiafzelechin [147] have been extracted from the wood of plant Xanthoceras sorbifolia has been prooved for the treatment of AIDS [57,145].…”

Section: Natural Plants As Protease Inhibitorsmentioning

confidence: 99%

Structure-Activity Relationship and Mechanistic Insights for Anti-HIV Natural Products

Kaur

Sharma

Gupta³

et al. 2020

Preprint

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Acquired Immunodeficiency Syndrome (AIDS) which is chiefly originated by a retrovirus named Human Immunodeficiency Virus (HIV), has influenced about 70 million populations worldwide. Even though several advancements have been invented in the field of antiretroviral combination therapy, still HIV has become the dominant reason for death in South Africa, for example. The current antiretroviral therapies have achieved success in providing instant HIV suppression but with countless undesirable adverse effects. In the present day, the biodiversity of the plant kingdom is being explored by several researchers for the discovery of potent anti-HIV drugs with different mechanisms of action. The primary challenge is to afford a treatment that is free from any sort of risk of drug resistance and serious side effects. Hence, there is a strong demand to evaluate the drugs obtained from natural plants as well as the synthetic derivatives that have been derived from the natural compounds by various chemical reactions. Several plants such as Andrographis paniculata, Dioscorea bulbifera, Aegle marmelos, Wistaria floribunda, Lindera chunii, Xanthoceras sorbifolia and others have displayed significant anti-HIV activity showing more potent anti-HIV activity along with their structures, SARs & important key findings.

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Flavonoids from Daphne aurantiaca and Their Inhibitory Activities against Nitric Oxide Production

Cited by 21 publications

References 28 publications

A Review on Sources and Pharmacological Aspects of Sakuranetin

A Review on Sources and Pharmacological Aspects of Sakuranetin

Two New Flavonoids from Dragon's Blood of Dracaena cambodiana

Structure-Activity Relationship and Mechanistic Insights for Anti-HIV Natural Products

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