A Review on Sources and Pharmacological Aspects of Sakuranetin

Abstract

Sakuranetin belongs to the group of methoxylated flavanones. It is widely distributed in Polyomnia fruticosa and rice, where it acts as a phytoalexin. Other natural sources of this compound are, among others, grass trees, shrubs, flowering plants, cheery, and some herbal drugs, where it has been found in the form of glycosides (mainly sakuranin). Sakuranetin has antiproliferative activity against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320). Moreover, sakuranetin shows antiviral activity towards human rhinovirus 3 and influenza B virus and was reported to have antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties. The aim of this review is to present the current status of knowledge of pro-health properties of sakuranetin.

FTICR/MS Analysis of Micromeria Fruticosa and Teucrium Polium Growing in Lebanon

“…6 This is consistent with the previous studies that reported the anticancer properties of Sakuranetin. [17][18][19] Many 23), B4(Figure 24), B5(Figure 25), B6(Figure 26), B7(Figure 27) and B13 (Figures 28 and 29) respectively. In our previous study, fractions B5 and B13 showed cytotoxic activity.…”

Special Issue “Dietary (Poly)Phenols and Health”

“…I am pleased that 19 papers published in this Special Issue [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ], present novel findings and adhere to the above-mentioned current trends. I personally consider the fact, that some papers in this issue also reported negative or only mild effects of the tested compounds to be very important as well.…”

“…The mechanism(s) of this process are also discussed by the authors of [ 27 ]. Current knowledge on sakuranetin, one of less explored flavanones, was also published in this issue [ 23 ]. Wüpper et al summarize available data on the chemical composition, pharmacological effects, and safety of Kuding tea, which contains polyphenolic compounds and triterpenic saponins [ 26 ].…”

Escaping mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds

“… Inhibition of ATP synthase complex [195] 9. Sakuranetin Asteraceae species (Polymnia fruticosa, Baccharis retusa), Himalayan cherry (Prunus puddum) H. pylori (MIC= 87.3 μM) Inhibition of HpFabZ enzyme [196] 10. Curcumin (Diferuloylmethane) Turmeric ( Curcuma longa ) E. faecalis, S. aureus, P. aeruginosa Membrane leakage [197] 11.…”