Escaping mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds

Jadimurthy, Ragi; Mayegowda, Shilpa Borehalli; Nayak, S. Chandra; Mohan, Chakrabhavi Dhananjaya; Rangappa, Kanchugarakoppal S.

doi:10.1016/j.btre.2022.e00728

Cited by 25 publications

(10 citation statements)

References 207 publications

(227 reference statements)

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“…Area of inhibition seen the media indicates the death or lysis of bacterial cell due to action of NPs used in the current study. This is the place where bacteria are unable to grow or become static with the given NP at minimum inhibitory concentration which prevents visible growth of a microorganism after overnight incubation with media similar to several of antibiotics used in the treating infections ( Jadimurthy et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

“…In the current study, we have used three pathogens which are known to be nosocomial organisms found normally on the skin and mucous membranes and cause primary and secondary infections when contracted by a patient while under medical care. The green NPs are known to pose several bactericidal and bacteriostatic bioactive compounds like tannins, flavonoids, alkaloids, glycosides, and saponins ( Jadimurthy et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

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Green synthesis of MgO nanoparticles and its antibacterial properties

et al. 2023

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Magnesium oxide nanostructured particles (NP) were prepared using a simple solution combustion technique using different leaf extracts such as Mangifera indica (Mango - Ma), Azadirachta indica (Neem—Ne), and Carica papaya (Papaya—Pa) as surfactants. The highly crystalline phase of MgO nanostructures was confirmed by PXRD and FTIR studies for 2 h 500°C calcined samples. To analyze the characteristics of obtained material–MaNP, NeNP, and PaNP for dosimetry applications, thermoluminescence (TL) studies were carried out for Co-60 gamma rays irradiated samples in the dose range 10–50 KGy; PaNP and NeNP exhibited well-defined glow curve when compared with MaNP samples. In addition, it was observed that the TL intensity decreases, with increase in gamma dose and the glow peak temperature is shifted towards the higher temperature with the increase in heating rate. The glow peak was segregated using glow curve deconvolution and thermal cleaning method. Kinetic parameters estimated using Chen’s method, trap depth (E), and frequency factor (s) were found to be 0.699, 7.408, 0.4929, and 38.71, 11.008, and 10.71 for PaNP, NeNP, and MaNP respectively. The well-resolved glow curve, good linear behavior in the dose range of 10–50, KGy, and less fading were observed in PaNP as compared with MaNP and NeNP. Further, the antibacterial activity was checked against human pathogens such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. A visible zone of clearance was observed at 200 and 100 μg/mL by the PaNP and NeNP, indicating the death of colonies by the nanoparticles. Therefore, PaNP nanomaterial is a potential phosphor material for dosimetry and antibacterial application compared to NeNP and MaNP.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Green synthesis of MgO nanoparticles and its antibacterial properties

et al. 2023

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“…Essential oils derived from the plants are efficient, which depends on their chemical structure, particularly with the hydrophilic functional groups that they possess such as the hydroxyl groups [ 29 ]. The compounds of these naturally occurring essential oils (EOs) are the volatile secondary metabolites that are derived from different parts of the plants [ 30 , 31 ]. The components of essential oils are had been variously studied and have different characteristics like the polypeptides, phenols, tannins, polyphenols, quinones, terpenoids, flavones, lectins, and alkaloids.…”

Section: Sources Of Antimicrobial Agentsmentioning

confidence: 99%

“…Similar to the skin, it acts as the physical barrier to protect us from the invasion of many pathogens in fruits like the peel outer covering. Several investigation evidences show that the fruit peel is mostly disposed as waste that is found to be sustainable resource containing antimicrobial activity [ 30 , 41 ]. In a study done by Jagtap and Bapat [ 42 ], team has shown pomegranate extract reduces the expansion of E. coli due to its great antimicrobial activity as it contains phenols and flavonoids.…”

Section: Sources Of Antimicrobial Agentsmentioning

confidence: 99%

Role of Antimicrobial Drug in the Development of Potential Therapeutics

Mayegowda

Alghamdi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Population of the world run into several health-related emergencies among mankind and humans as it creates a challenge for the evolution of novel drug discoveries. One such can be the emergence of multidrug-resistant (MDR) strains in both hospital and community settings, which have been due to an inappropriate use and inadequate control of antibiotics that has led to the foremost human health concerns with a high impact on the global economy. So far, there has been application of two strategies for the development of anti-infective agents either by classical antibiotics that have been derived for their synthetic analogs with increased efficacy or screening natural compounds along with the synthetic compound libraries for the antimicrobial activities. However, need for newer treatment options for infectious diseases has led research to develop new generation of antimicrobial activity to further lessen the spread of antibiotic resistance. Currently, the principles aim to find novel mode of actions or products to target the specific sites and virulence factors in pathogens by a series of better understanding of physiology and molecular aspects of the microbial resistance, mechanism of infection process, and gene-pathogenicity relationship. The design various novel strategies tends to provide us a path for the development of various antimicrobial therapies that intends to have a broader and wider antimicrobial spectrum that helps to combat MDR strains worldwide. The development of antimicrobial peptides, metabolites derived from plants, microbes, phage-based antimicrobial agents, use of metal nanoparticles, and role of CRISPR have led to an exceptional strategies in designing and developing the next-generation antimicrobials. These novel strategies might help to combat the seriousness of the infection rates and control the health crisis system.

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“…pathogens and mechanisms improved by ESKAPE pathogens to respond antibiotics have been discussed by Jadimurthy et al. [12] . To investigate how the inoculants Native Efficient Microorganisms (NEM) and the commercial product EM1® affected the production of rootstock Poncirus trifoliata (L.) Raf seedlings and the development of young Sweet Orange "Valência" ( Citrus sinensis (L.) Osbeck) and Murcott tangora plants ( Citrus sinensis x Citrus reticulata Blanco).…”

Section: Editorialmentioning

confidence: 99%