Flavonoids, Antioxidant Potential, and Acetylcholinesterase Inhibition Activity of the Extracts from the Gametophyte and Archegoniophore of Marchantia polymorpha L.

Wang, Xin; Cao, Ji; Wu, Yuhuan; Wang, Quanxi; Xiao, Jianbo

doi:10.3390/molecules21030360

Cited by 43 publications

(44 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The chemicals were the same with previous report [14]. Rutin (purity > 99.0%), 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), Nitrotetrazolium blue chloride (NBT), phenazine methosulfate (PMS), nicotinamide adenine dinucleotide (NADH), 5, 5’-dithiobis-(2-nitrobenzoic acid) (DTNB) and 2,4,6-tri-2-pyridyl-s-triazine (TPTZ) were purchased from Sigma Co. (Shanghai, China).…”

Section: Methodsmentioning

confidence: 99%

Effects of different pretreatments on flavonoids and antioxidant activity of Dryopteris erythrosora leave

Wang

Zhang

wang

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

18Flavonoids with wide bioactivity for medcine are vital secondary metabolite of plant. The factors 19 influenced on flavonoids had been reported. However, as the key processes lead to metabolite 20 alterations, the influences of the different pretreatments of samples on flavonoids and antioxidant 21 activity of ferns were with little information. Therefore, Dryopteris erythrosora leaves were chosen 22 as the materials for analyzing flavonoids alterations, which would not only provide the significant 23 basic data for flavonoid metabolism of fern, but also for further developing fern resources. The 2 24 results showed that a) The total flavonoids contents of D. erythrosora leaves with different 25 pretreatments were obviously different. The total flavonoid contents of samples, which was dried in 26 shade firstly and then dried at 75 °C in oven, finally smashed, was the highest (7.6%), but that of 27 samples, which was quickly dried at 75 °C in oven directly after cleaning and then smashed, was the 28 lowest (2.17%); b) Antioxidant activities of D. erythrosora leaves with different pretreatments were 29 variant. Samples, which were dried in shade firstly and then dried at 75 °C in oven, finally smashed 30 and samples which were firstly dried in the sun and then dried at 75 °C in oven, ultimately smashed, 31 both showed stronger antioxidant activity; c) Total twenty-three flavonoids with four different 32 pretreatments were tentatively identified by HPLC-ESI-TOF-MS. In conlusion, a) The influences of 33 different pretreatments on flavonoids and antioxidant activity of D. erythrosora Leaves were 34 obvious. b) The best pretreatment in respect to conserving fern medical application was drying in 35 shade firstly and then drying at 75 °C in oven, finally smashed. 36

show abstract

Section: Methodsmentioning

confidence: 99%

Effects of different pretreatments on flavonoids and antioxidant activity of Dryopteris erythrosora leave

Wang

Zhang

wang

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…[14][15][16] These findings suggest that natural products, including herbal medicines, may be complementary and alternative approaches to Western medicine for the treatment of Alzheimer's disease. Although recent studies of Alzheimer's disease therapy have been shifting to other targets, such as amyloid-β, 17) Tau, 18) reactive oxygen species, 19) and the blood-brain barrier, 20) AChE inhibitors are still the first choice for treating patients with AD.…”

Section: Resultsmentioning

confidence: 99%

Neuroprotective Effect of <i>Corydalis ternata</i> Extract and Its Phytochemical Quantitative Analysis

et al. 2017

View full text Add to dashboard Cite

The tubers of Corydalis ternata have been used to treat cardiovascular diseases such as hypertension and cardiac arrhythmia. Its active components have anticholinesterase, antiamnesic, and anti-inflammatory activities, and analgesic effects. In the present study, we performed quantitative analyses of the two components of C. ternata, coptisine and berberine, using HPLC. A 70% ethanol extract of C. ternata was prepared and the two components were separated using a C-18 analytical column on a gradient solvent system of acetonitrile and 0.1% (v/v) aqueous trifluoroacetic acid. Recordings were performed at a UV wavelength of 265 nm for two standard components. The established analytical method showed high linearity (correlation coefficient (r) 1.0000) and proper precision (0.49-3.88%), accuracy (97.88-102.7%), and recovery (95.12-103.79%) for two standard components. The amount of the coptisine and berberine was 4.968 0.089 mg/g and 3.73 0.075 mg/g, respectively. In addition, we investigated the effects of coptisine and berberine on acetylcholinesterase activity and amyloid-β aggregation, which are major biomarkers of dementia. Coptisine and berberine decreased acetylcholinesterase activity in a dose-dependent manner (IC 50 0.74 and 0.48 µM, respectively). The C. ternata extract exerted an antioxidant activity by stimulating the radical scavenging activity of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), but not 2,2-diphenyl-1-picrylhydrazyl (DPPH). Furthermore, the C. ternata extract reversed the hydrogen peroxide-induced death of HT22 hippocampal cells, indicating its neuroprotective effect. Our results suggest the potential of C. ternata as a therapeutic agent against dementia via the inhibition of acetylcholinesterase activity and neuronal cell death.

show abstract

“…Therefore, we further analyzed the chemical composition of SC 1,3‐butanediol extract by UHPLC‐QTOF; finally, 12 kaempferol compounds were found in SC 1,3‐butanediol extract and kaempferol 3‐O‐[α‐rhamnopyranosyl‐(1→6)‐β‐glucopyranoside] and kaempferol‐3,7‐O‐α‐L‐dirhamnoside were two major compounds. In fact, kaempferol belongs to the flavonoids, previous a large number of works indicated that flavonoids have anti‐tyrosinase, anti‐melanogenic, antioxidant, and anti‐inflammatory activity . It is well known that tyrosinase catalyzes tyrosine and eventually leads to the production of melanin, so compounds with similar structures to tyrosinase compete to inhibit the activity of tyrosinase.…”

Section: Discussionmentioning

confidence: 99%

“…3 In order to further develop the value of shell of Camellia oleifera Abel, in this study, we aim to examine the ability of SC extracts to inhibit in vitro tyrosinase activity and and anti-inflammatory activity. [16][17][18][19] It is well known that tyrosinase catalyzes tyrosine and eventually leads to the production of melanin, so compounds with similar structures to tyrosinase compete to inhibit the activity of tyrosinase. Both kaempferol and tyrosine have similar phenolic hydroxyl structure, which will directly affect the first step of tyrosinase-catalyzed reaction.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of shell of Camellia oleifera Abel extract on mushroom tyrosinase and human skin melanin

Liu

Wang

et al. 2019

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Summary Background As an oil production byproducts, the shell of Camellia oleifera Abel (SC) is usually discarded in the dump. However, previous investigations suggested that the SC could provide valuable bioactive materials. Objective The objectives of this study were to examine the ability of SC extract to inhibit in vitro tyrosinase activity and the melanin inhibition effects of cosmetic formulations containing SC 1,3‐butanediol extract in human volunteers. Methods The cell viability was determined using a WTT assay. A mushroom tyrosinase was used to evaluate the anti‐tyrosinase activity of the SC extract. The placebo (no extract) or test (SC 1,3‐butanediol extract) or positive control (kojic acid) cosmetic cream was applied on face of volunteers(30 female subjects) three times a day for 8 weeks. The active compounds in SC extract were screened using liquid chromatography‐high‐resolution mass spectrometry (UHPLC‐QTOF). Results The result showed that the cytotoxicity of SC extract is insignificant when the concentration of SC extract is below 160 µg/mL. In addition, SC extract dose dependently inhibited tyrosinase activity and SC 1,3‐butanediol extract possessed a stronger inhibitory activity than methanol extract and water extract. Clinical evaluations revealed that facial melanin levels of the volunteers receiving cosmetic formulations (containing SC 1,3‐butanediol extract) were decreased 59% from baseline in 6th weeks, whereas the placebo group showed no effect. SC 1,3‐butanediol extract was detected to contain 12 kaempferol compounds, significantly, kaempferol 3‐O‐[α‐rhamnopyranosyl‐(1→6)‐β‐glucopyranoside] and kaempferol‐3,7‐O‐α‐L‐dirhamnoside are the major compounds. Conclusion These results indicate that SC extract can be used as a natural skin‐whitening agent in cosmetic products.

show abstract

Flavonoids, Antioxidant Potential, and Acetylcholinesterase Inhibition Activity of the Extracts from the Gametophyte and Archegoniophore of Marchantia polymorpha L.

Cited by 43 publications

References 28 publications

Effects of different pretreatments on flavonoids and antioxidant activity of Dryopteris erythrosora leave

Effects of different pretreatments on flavonoids and antioxidant activity of Dryopteris erythrosora leave

Neuroprotective Effect of <i>Corydalis ternata</i> Extract and Its Phytochemical Quantitative Analysis

Inhibitory effects of shell of Camellia oleifera Abel extract on mushroom tyrosinase and human skin melanin

Contact Info

Product

Resources

About