Flavonoids: Anticancer Properties

Abstract

Flavonoids are plant secondary metabolites. They are mainly classified into four major groups, such as flavanols, flavones, anthocyanidins, and isoflavonoids. Furthermore, they are divided into some subclasses. They are available in dietary foods and they cure various diseases. Certain plants and spices contain flavonoids, which have been commonly used for thousands of years in traditional medicine. Some of the flavonoids have been clinically used in many countries. Baicalein and its glycosides are one among them to have been experimented clinically. Flavonoids have the capability to regulate cell division and proliferation in an important pathway. They have medicinal activities including anticancer properties. The isoflavone analog rotenone is one of the flavonoid compounds, which has been revealed to be actual anticancer agent. Scutellaria species having flavones retain cytotoxic activities against many human cancer cell lines. At the same time, they do not harm the myeloid cells, normal peripheral and normal epithelial blood cells. Epidemiological studies also confirmed that the intake of dietary flavonoids reduces a risk condition in cancer.

Antioxidant, Anti-tyrosinase, Anti-α-amylase, and Cytotoxic Potentials of the Invasive Weed Andropogon virginicus

“…Remarkably, the antioxidant activity of flavonoids is closely associated with anticancer regulation [ 50 ]. Meanwhile, phytoflavonoids are not harmful to normal myeloid, peripheral blood, and epithelial cell lines [ 51 ]. In our research, we also find a strong correlation between total phenolics and flavonoids, antioxidant and cytotoxic capacities in the ethyl acetate extract ( Table 4 ).…”

Medicinal Properties Screening of Mallotus paniculatus Extract

“…33 From previous studies, flavonoids have been shown to induce cell cycle arrest in G2 and mobile phase of cell cycle, inhibited heat-shock protein, tyrosine kinase and Ras protein as well as downregulated oestrogen receptor-binding capacity. 34 As most pathogenesis of cancer involve genetic abnormalities that result in p53-mutated proteins, downregulation of these proteins by flavonoid intake also affect cancer growth. 34 Interestingly, other Mallotus species such as M. apelta was found to have a strong cytotoxic effect against cancer cells.…”

“…34 As most pathogenesis of cancer involve genetic abnormalities that result in p53-mutated proteins, downregulation of these proteins by flavonoid intake also affect cancer growth. 34 Interestingly, other Mallotus species such as M. apelta was found to have a strong cytotoxic effect against cancer cells. Benzopyran, 6-[10-oxo-30(R)-hydroxybutyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran, that was present in the plant was cytotoxic against two human cancer cell lines, human hepatocellular carcinoma and rhabdosarcoma.…”

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“…In a study Longchar and Prasad [47] reported that combination treatment with ascorbic acid plus cisplatin has better therapeutic efficacy against murine ascites DL in comparison to cisplatin alone treatment and simultaneously helps in the recovery in cisplatininduced hematological values and significant reduction in mutagenic and genotoxic effects [14]. It has been reported that rutin effectively ameliorates the alterations in the hematological parameters through its antioxidant nature [49] and the side-effects of synthetic drugs may be decreased due to flavonoid content in the combinational drugs [50]. Thus, it may be suggested that rutin plus cisplatin combination treatment while illustrating protective ability against cisplatin induced hematotoxicity has promising therapeutic efficacy against cancers in general and murine ascites Dalton's lymphoma in particular.…”