Flavonoids and oxepinones from the leaves and twigs of Desmos cochinchinensis and their α-glucosidase inhibitory activities

Meesakul, Pornphimol; Richardson, Christopher; Pyne, SG; Laphookhieo, Surat

doi:10.1055/s-0039-3399883

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2020

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“…Recently, a number of natural α-glucosidase inhibitors has been reported from plants and fungi [23,26,27]. In an early work, we isolated 9 new meroterpenoid derivatives with the α-glucosidase inhibitory activity from the mycelia extract of H. erinaceus Identification and α-Glucosidase Inhibitory Activity of Meroterpenoids from Hericium erinaceus [23].…”

Section: Introductionmentioning

confidence: 99%

Identification and α-Glucosidase Inhibitory Activity of Meroterpenoids from Hericium erinaceus

Chen

Han

et al. 2020

Planta Med

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Hericium erinaceus is a very popular edible and medicinal mushroom used for the treatment of enervation and gastrointestinal diseases in Eastern Asia. Chemical investigation on the fruiting body of Hericium erinaceus led to the isolation of 4 new (1 – 4) and 10 known meroterpenoids (5 – 14). The structures of new compounds were determined via analysis of NMR and MS data in combination with chemical derivatization. The inhibitory activities of 1 – 14 against α-glucosidase were evaluated using p-nitrophenyl-α-D-glucopyranoside, sucrose, or maltose as substrate. Compounds 6, 9, 11 – 13 were demonstrated to show the α-glucosidase inhibitory activities. This work confirms the potential of H. erinaceus in the treatment of diabetes.

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