Flavonoids and isoflavones: absorption, metabolism, and bioactivity

Rice‐Evans, Catherine

doi:10.1016/j.freeradbiomed.2003.12.012

Cited by 190 publications

(109 citation statements)

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“…Moreover, recent studies have examined the permeability of flavonoids and their known circulating metabolites across the blood-brain barrier (BBB). Flavonoids are hydrolyzed in the gut and then glucuronized, so it is quite possible that a glycosidal form reaches the central nervous system (CNS) 44 . In particular, Youdim et al 45 reported that flavonoids from particular families are able to permeate the BBB, whereas the entry of others is limited by the actions of efflux transporters expressed at the endothelium surface.…”

Section: Anticholinesterase Activitymentioning

confidence: 99%

Metabolite profile and in vitro activities of Phagnalon saxatile (L.) Cass. relevant to treatment of Alzheimer’s disease

Conforti

Rigano

Formisano

et al. 2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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Section: Anticholinesterase Activitymentioning

confidence: 99%

Metabolite profile and in vitro activities of Phagnalon saxatile (L.) Cass. relevant to treatment of Alzheimer’s disease

Conforti

Rigano

Formisano

et al. 2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Medicinal plants are an important source of antioxidants [19]. Natural antioxidants increase the antioxidant capacity of the plasma and reduce the risk of certain diseases.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial and Antioxidant Activity of Leucas Aspera Flowers From Bihar, India.

sabri

Vimala

2018

Asian J Pharm Clin Res

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Objective: The aim of this study was to explicate antibacterial, antifungal, and antioxidant activities of Leucas aspera flowers.Methods: Antibacterial activity was done by agar diffusion method. The ethyl acetate extract of L. aspera flower was evaluated against both Grampositive and Gram-negative bacteria. Antifungal activity was also done by agar diffusion method. The agar used for antifungal activity was Czapek Dox Agar. Nitric oxide scavenging assay and free radical scavenging assay were used for the antioxidant activity. Griess reagent was used in nitric oxide scavenging assay. 1,1-diphenyl-2-picryl hydrazyl was used in free radical scavenging assay.Results: L. aspera flower extract showed good antibacterial activity with the highest zone of inhibition against Vibrio cholera with 23 mm followed by Bacillus polymyxa showing 20 mm zone of inhibition. The ethyl acetate extract of L. aspera flower showed quite a good results with the highest inhibitory activity against Aspergillus niger with 13 mm zone of inhibition and lowest for Trichoderma viridae with 5 mm zone of inhibition. Antioxidant activity of L. aspera flower extract was done by free radical scavenging assay and nitric oxide scavenging assay. Nitric oxide scavenging assay showed prominent results almost performed equal to standard compound Butylated hydroxyl anisole (BHA) The values for 10 μl of L. aspera extract was 50.27, for the standard (BHA) showed 50.81. L. aspera extract values for 50 μl was 69.73 and for BHA, the values was 77.30. For 100 µl, the extract gave 82.70, and for standard BHA, the reading was 89.73. Conclusion:The results showed that L. aspera flower has broad-spectrum antibacterial activity ranging from 23 to 13 mm zone of inhibition. L. aspera flower has strong antioxidative power on nitric oxide radicals. The medicinal properties of plant species have made an outstanding contribution to the origin and evolution of many traditional herbal therapies.

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“…Phenolic compounds from plants belong to a class of bioactive compounds that have received much attention during recent years, mainly owing to their positive effects on diet-health interaction in human nutrition [25] and antioxidants have capacity to mobilize protective effects against oxidative stress due to their high antioxidant activity [26]. Table 1 shows the contents of total phenolics and flavonoids.…”

Section: Total Phenolic and Flavonoid Contentmentioning

confidence: 99%

Evaluation of Total Phenolic, Flavonoidal Content, and DPPH Free Radical Scavenging Activity of Methanolic Extract of Ailanthus Excelsa Roxb.

Kumari¹,

Sharma²

2017

Asian J Pharm Clin Res

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Objective: Estimation of total phenol, flavonoid, and antioxidant activity of various plant parts (leaves, stem, root, flower, and fruit) of Ailanthus excelsa Roxb. methanolic extracts.Methods: Different plant parts were extracted with methanol, then the total phenol content was calculated using Folin-Ciocalteu reagent, total flavonoid content was estimated using aluminum chloride colorimetric method and the antioxidant activity was measured by 1,1-diphenyl-2-picrylhydrazyl radical assay. Results:The highest total phenolic content 48.38 mg gallic acid equivalent [GAE]/gdw was observed in flower and lowest phenolic content in root (28.56 mg GAE/gdw). The highest total flavonoid content (21.5 mg quercetin equivalent [QE]/gdw) was found in leaf and lowest in root (1.11 mg QE/gdw). The highest radical scavenging activity was found in flower extracts with the inhibitory concentration value of 36.85 µg/ml and the lowest scavenging activity was observed in root extract that was found to be 1493.46 µg/ml. Conclusion:According to the results of present investigation the plant showed significant antioxidant activity that can be used for medical purpose for the treatment of various diseases.

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Flavonoids and isoflavones: absorption, metabolism, and bioactivity

Cited by 190 publications

References 0 publications

Metabolite profile and in vitro activities of Phagnalon saxatile (L.) Cass. relevant to treatment of Alzheimer’s disease

Metabolite profile and in vitro activities of Phagnalon saxatile (L.) Cass. relevant to treatment of Alzheimer’s disease

Antibacterial and Antioxidant Activity of Leucas Aspera Flowers From Bihar, India.

Evaluation of Total Phenolic, Flavonoidal Content, and DPPH Free Radical Scavenging Activity of Methanolic Extract of Ailanthus Excelsa Roxb.

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