Flavonoids and Coumarins from Leaves of<i>Phellodendron chinense</i>

Kuo, Ping Chung; Hsu, Meei Yu; Damu, Amooru G.; Su, Chung Ren; Sun, Han; Wu, Tian Shung

doi:10.1055/s-2004-815500

Cited by 10 publications

References 6 publications

(7 reference statements)

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Biosynthesis of Phenylpropanoids and Related Compounds (FromAPRVolume 40)

Petersen

Hans

Matern

2018

Annual Plant Reviews Online

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Phenolic compounds are ubiquitous in the plant kingdom. A main pathway for the formation of these compounds starts with the aromatic amino acidsl‐phenylalanine and – to a lesser extent –l‐tyrosine. In the general phenylpropanoid pathway, these are transformed to coenzyme A‐activated 4‐coumaric acid by phenylalanine ammonia‐lyase, cinnamic acid 4‐hydroxylase and 4‐coumarate CoA‐ligase. 4‐Coumaroyl‐CoA gives rise to a large number of different natural products, e.g. flavonoids, lignans, coumarins, tannins, hydroxycinnamic acid esters and amides as well as lignin monomers. This review gives an insight into recent findings concerning the general phenylpropanoid pathway as well as the biosyntheses of hydroxycinnamoyl conjugates, phenolic aroma and fragrance compounds, lignans, coumarins and gallo‐/ellagitannins.

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Biosynthesis of Phenylpropanoids and Related Compounds (FromAPRVolume 40)

Petersen

Hans

Matern

2018

Annual Plant Reviews Online

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Biosynthesis of Phenylpropanoids and Related Compounds

Petersen

Hans

Matern

Biochemistry of Plant Secondary Metabolism

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A LC‐MS/MS method for simultaneous determination of seven alkaloids in rat plasma after oral administration of Phellodendri chinensis cortex extract and its application to a pharmacokinetic study

Wang

Song

Cui

et al. 2019

J of Separation Science

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A sensitive and rapid liquid chromatography with tandem mass spectrometry method has been developed for simultaneous determination of berberine (I), jateorhizine (II), palmatine (III), tetrahydropalmatine (IV), phellodendrine (V), protopine (VI) and columbamine (VII) in rat plasma after oral administration of Phellodendri chinensis cortex extraction. The plasmas were extracted by liquid‐liquid extraction. The tandem mass spectrometric detection was performed in the multiple reaction monitoring mode in the positive ionization. The intra‐ and interday precisions and accuracies were in range from −12.18 to 13.21%. Mean absolute recoveries of all analytes and internal standard were between 78.6 and 98.9%. The seven alkaloids were proven to be stable during sample storage and analysis procedures. The established method was validated and successfully applied to pharmacokinetics study in rat plasma after oral administration of Phellodendri chinensis cortex extract. The t1/2 of palmatine, columbamine, pellodendrine, berberine, tetrahydropalmaine, jatrorrhizine, and protopine were 5.16, 5.96, 7.18, 19.84, 6.28, 7.08, 6.90 h, respectively. The seven compounds could be rapidly absorbed into blood (time for maximal concentration, 1.80–1.93 h). This study could establish a foundation for further research of Phellodendri chinensis cortex and might provide more useful information to guide the clinical usage.

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Flavonoids and Coumarins from Leaves ofPhellodendron chinense

Cited by 10 publications

References 6 publications

Biosynthesis of Phenylpropanoids and Related Compounds (FromAPRVolume 40)

Biosynthesis of Phenylpropanoids and Related Compounds (FromAPRVolume 40)

Biosynthesis of Phenylpropanoids and Related Compounds

A LC‐MS/MS method for simultaneous determination of seven alkaloids in rat plasma after oral administration of Phellodendri chinensis cortex extract and its application to a pharmacokinetic study

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