Flavonoid bioactive compounds of hawthorn extract can promote growth, regulate electrocardiogram waves, and improve cardiac parameters of pulmonary hypertensive chickens

Abstract

The effect of orally administered hawthorn flavonoid extract ( HFE ) on growth, electrocardiographic waves, and cardiac parameters of pulmonary hypertensive chickens reared at high altitude (2,100 m above sea level) was examined. A total of 225 one-day-old, mixed broiler chicks (3 treatments with 5 replicates and 15 chicks per each, totally 75 birds/treatment) were assigned to 3 experimental groups: 0, 0.1, and 0.2 ml of HFE per 1 L of drinking water. Birds were administered the drinking water HFE treatments for 42 D. At an age of 28 and 42 D, electrocardiograms were undertaken and cardiac parameters such as the RV:TV, RV:BW, and TV:BW, and indicators of PHS on selected birds were measured. The final BW of chickens receiving the HFE at 0.2 ml/L was greater (2,579 ± 64 g) than that of birds receiving 0.1 ml/L (2,497 ± 62 g) and 0 ml/L (2,323 ± 57 g). Therefore, no supplemented group had a lower final BW than others ( P < 0.05). Amplitudes of S and T waves in 0.1- and 0.2-ml/L HFE consumed groups at 28 and 42 D of age decreased compared with that in the control group ( P < 0.05). The HFE reduced the heart weight and RV:TV, RV:BW, and TV:BW ratios when supplemented in drinking water at 0.1 and 0.2 mL/L compared with 0 mL/L ( P < 0.05). In conclusion, supplementation of HFE in drinking water can reduce the PHS and incidence of cardiac disorders. Owing to the positive effect of HFE on cardiac parameters that mediated through flavonoids bioactive compounds, this product can be used to prevent complications of pulmonary hypertension and disarray of electrocardiographic waves in broiler chickens reared at high altitude.

Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities

“…Baicalin and chrysin may reduce collagen deposition [ 68 , 153 ]. Resveratrol, curcumin, hydroxysafflor yellow A, allicin, hawthorn, and other natural products have protective effects on the heart [ 99 , 157 , 158 , 159 , 160 ]. Of course, there are other pathways, such as metabolism, genetics, etc., but they have not been summarized because fewer natural products are involved [ 65 , 164 ].…”

“…MLB improves right ventricular remodeling in pulmonary hypertension by inhibiting the NOX/VPO1 pathway [ 44 ]. In addition, many other natural products, such as hydroxysafflor yellow A, allicin, hawthorn, and breviscapine, have a protective effect on the right ventricle through several pathways [ 158 , 159 , 160 , 161 ].…”

Effects of compound of hawthorn (Crataegus pinnatifida) and Chinese yam (Dioscorea opposita Thunb.) extracts on growth performance, intestinal health, and immune function in weaned pigs

“…has been used in China for hundreds of years and is widely recognized for its therapeutic effects on anorexia and diarrhea (Kong et al, 2009; Shin et al, 2006). Recent studies have shown that the addition of hawthorn extract to broilers (Ahmadipour et al, 2020; Dai et al, 2021; Zhang et al, 2009) or juvenile golden pompano ( Trachinotus ovatus ) (Tan et al, 2017) diets significantly improved growth performance and enhanced immunity and antioxidant capacity. Yam extract can improve the growth performance and immunity of weaned rats (Kong et al, 2009) and improve the immunity of the common carp by regulating intestinal microbiota and enhancing intestinal defense barrier (Meng et al, 2019).…”

LC–MS-based lipidomic analysis of liver tissue sample from spontaneously hypertensive rats treated with extract hawthorn fruits

“…The rich polyphenolic components of hawthorn peel and pulp could differentially modulate dyslipidemia, inflammation, oxidative stress, and alleviate liver injury in mice, which is the main reason for its excellent antioxidant and free radical scavenging abilities ( Han et al, 2016 ; Zhao et al, 2017 ). The mediated cardiogenic, vasodilatory and antioxidant effects of flavonoid bioactive compounds in hawthorn extracts making them beneficial in the prevention of pulmonary hypertension syndrome and heart disease ( Ahmadipour et al, 2020 ). Flavonoids and oligomeric proanthocyanidins play a major role in the protection and treatment of various CDVs ( Rigelsky and Sweet, 2002 ).…”