Flavones: An important scaffold for medicinal chemistry

Singh, Manjinder; Kaur, Maninder; Silakari, Om

doi:10.1016/j.ejmech.2014.07.013

Cited by 454 publications

(302 citation statements)

References 284 publications

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“…Nitrogen containing flavones have been reported to have considerable antimicrobial activity. The compounds, bearing amino alkyl, cyano-or alkenyl alkyl group on piperazine are found to be the potent antibacterial and antifungal agents (Singh et al, 2014). Cushnie and Lamb (2005) revealed that flavonoids possess capabilities to form complexes with extracellular soluble protein and bacterial cells.…”

Section: Resultsmentioning

confidence: 99%

The Antimicrobial Properties Of Extracts Obtained From Begonia Goegoensis N.E.Br. Leaf Against Pseudomonas Aeruginosa Isolates

Tkachenko¹,

Osadowski²,

Buyun³

2017

Agrobiodiversity for Improving Nutrition, Health and Life Quality

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The present study was designed to evaluate the antibacterial property of crude extracts of the leaves of Begonia goegoensis N.E.Br. prepared in different solvent systems against Pseudomonas aeruginosa (ATCC 27583) and β-lactamases producing Pseudomonas aeruginosa (MBL-positive Pseudomonas aeruginosa) strains. Therefore, five kinds of solvents were used to extract the active ingredients from the leaves of Begonia goegoensis: ethanol, methanol, ethyl acetate, hexane, and dichloromethane. The testing of antibacterial activity of the plant extracts was carried out in vitro by Kirby-Bauer disc diffusion technique. Subsequently, the present study has shown that ethanolic extract from the leaves of Begonia goegoensis exhibited strong activity against Pseudomonas aeruginosa (inhibition zone diameter ranged from 12 mm to 13 mm), while methanolic leaf extract screened revealed less profound activity (within 11-12.5 mm). Moreover, it has been observed that ethyl acetate, hexane and dichloromethane extracts obtained from leaves of Begonia goegoensis revealed no antibacterial activity against P. aeruginosa and MBL-positive Pseudomonas aeruginosa strains. MBL-positive Pseudomonas aeruginosa was also susceptible to ethanolic and methanolic extracts (inhibition zone diameter ranged from 12.5 mm to 15.5 mm). Thus, the spectrum of activity observed in the present study indicate that the alcoholic leaf extract of Begonia goegoensis could be a possible source to obtain new and effective herbal medicines to treat various infectious diseases, including infections, caused by drug resistant microorganisms.

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Section: Resultsmentioning

confidence: 99%

The Antimicrobial Properties Of Extracts Obtained From Begonia Goegoensis N.E.Br. Leaf Against Pseudomonas Aeruginosa Isolates

Tkachenko¹,

Osadowski²,

Buyun³

2017

Agrobiodiversity for Improving Nutrition, Health and Life Quality

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“…Amurensin, a flavanol derivative of kaempferol 7-O-glucoside, has been reported to show antioxidant properties through DPPH radical scavenging activity [19]. On the other hand, cosmosiin, an apigenin flavone glucoside, exhibited antioxidant, anticancer, antiinflammatory, cardioprotective and neuroprotective properties.…”

Section: Discussionmentioning

confidence: 99%

Isolation and identification of flavonoids from anticancer and neuroprotective extracts of <i>Trigonella foenum</i> graecum

Ahmed¹,

Hayat²,

Zahid³

et al. 2017

Trop. J. Pharm Res

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“…Flavonoids are reported to have anticancer activity by various mechanism such as carcinogen inactivation, cell cycle arrest, antiproliferation, induction of apoptosis and inhibition of angiogenesis 32,33 . Various research studies revealed that kinases such as dual specificity tyrosine phosphorylation-regulated kinase 1A (DYRK-1A), glycogen synthase kinase-3 (GSK3), cyclin-dependent kinases (CDKs) are involved in cancer 34,35 .…”

Section: Anticancermentioning

confidence: 99%

Untitled

2016

IJPSR

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Flavonoids are the natural compound widely distributed in plant kingdom, it is responsible for the various colors exhibited by bark, leaves, flowers, fruits and seeds of plants. They are the secondary metabolites of plant with significant antioxidant properties. Flavonoids have antioxidant, sedative, antidepressant, anticonvulsant, antiproliferative, anti-inflammatory, anti-microbial, anticancer, cardioprotective, antihypertensive, antiulcerogenic, antidiabetic and hepatoprotective activity. Many researchers have revealed that the above mentioned pharmacological actions are mainly due to its antioxidant property. Flavonoids have effect on mammalian enzymes like protein kinases, alpha-glucosidase and aldose reductase, thereby regulate multiple cellular signaling pathway that were altered during disease conditions. Various researches on flavonoids are in progress due to its versatile health benefits. En number of flavonoids are available in the market as pharmaceutical products because of its cost effective bulk production and health benefits. The present review is focused on the classification, metabolism, pharmacological and biological actions and flavonoid supplement available in market.

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Flavones: An important scaffold for medicinal chemistry

Cited by 454 publications

References 284 publications

The Antimicrobial Properties Of Extracts Obtained From Begonia Goegoensis N.E.Br. Leaf Against Pseudomonas Aeruginosa Isolates

The Antimicrobial Properties Of Extracts Obtained From Begonia Goegoensis N.E.Br. Leaf Against Pseudomonas Aeruginosa Isolates

Isolation and identification of flavonoids from anticancer and neuroprotective extracts of <i>Trigonella foenum</i> graecum

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