Flavan dimers with lipase inhibitory activity from Cassia nomame

Hatano, Tsutomu; Yamashita, Akiko; Hashimoto, Toshitaka; Ito, Hideyuki; Kubo, Naoki; Yoshiyama, Masaaki; Shimura, Susumu; Itoh, Yoshio; Okuda, Takuo; Yoshida, Takashi

doi:10.1016/s0031-9422(97)00367-1

Cited by 73 publications

(47 citation statements)

References 13 publications

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“…A small part of the active components of lipase inhibitors in CT-II were con®rmed as 3 H ,4 H ,7-trihydroxy¯avan-4a?8 catechin, and major active components were suggested to be 3 H ,4 H ,7-trihydroxy¯avan oligomers. 17 These are known as condensed tannins. It is well known that tannins can bind to various proteins and aggregate them.…”

Section: Discussionmentioning

confidence: 99%

Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame Herba, on rats fed a high-fat diet

Yamamoto¹,

Shimura²,

Itoh³

et al. 2000

Int J Obes

108

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OBJECTIVE: To investigate the inhibitory effects of CT-II, extract of Nomame Herba, on lipase activity in vitro and on obesity in rats fed a high-fat diet in vivo. DESIGN: The assay for the inhibitory effect of CT-II on lipase activity was performed by measuring released free fatty acids after the incubation of the medium with CT-II, porcine pancreatic lipase and triolein (experiment 1). In vivo experiments, lean rats or obese rats (570 ± 718 g) were fed a high-fat diet containing 60% fat with or without CT-II for 8 weeks (experiment 2), for 14 days (experiment 3) or for 12 weeks (experiment 4), respectively. MEASUREMENT: The time course of body weight, food intake, organ weight (parametrial fat, liver, heart and kidney) and plasma parameters (triglyceride, total cholesterol, glucose, AST, ALT and insulin), fecal output of total fat and total cholesterol were measured. Hepatic histological examinations were also performed. RESULTS: CT-II inhibited the porcine lipase activity dose-dependently in vitro (experiment 1). Body and liver weight were reduced and hepatic histological examination showed an amelioration of fatty liver in CT II treated animals (experiment 2). CT-II signi®cantly inhibited body weight gain and plasma triglyceride elevation in a dose-dependent manner, without affecting food intake in lean rats fed the high-fat diet. Elevated plasma AST and ALT were also decreased (experiment 3). When obese rats fed the high-fat diet were treated with CT-II for up to 6 months, body weight was initially reduced and thereafter weight gain was signi®cantly suppressed. Total body fat was also signi®cantly reduced and signi®cant reduction of plasma AST and ALT was observed (experiment 4). CONCLUSIONS: These results demonstrated that the lipase inhibitor CT-II is effective in preventing and ameliorating obesity, fatty liver and hypertriglyceridemia in rats fed a high-fat diet.

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Section: Discussionmentioning

confidence: 99%

Anti-obesity effects of lipase inhibitor CT-II, an extract from edible herbs, Nomame Herba, on rats fed a high-fat diet

Yamamoto¹,

Shimura²,

Itoh³

et al. 2000

Int J Obes

108

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“…Azuki beans extracts have an inhibitory effect on malonaldehyde formation, and thereby exert antioxidant activity (Lee & Lee, 2005;Lee et al, 2003). Azuki beans have also been suggested to have lipase inhibitor activity in vitro (Hatano et al, 1997;Shimura et al, 1994).…”

Section: Pulses and Other Diseasesmentioning

confidence: 99%

Minor components of pulses and their potential impact on human health

Campos-Vega

Oomah

2010

Food Research International

438

329

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“…In addition, some botanical foodstuffs such as the proteins in soybeans (Garugouri, Julien, Pieroni, Verger, & Sarda, 1984Higaki, 2003) and phosphatidyl choline and AR25 Ò from green tea extract (Juhel et al, 2000) have been reported as lipase inhibitors. The existence of lipase inhibitors is reported in various plant species, including Cassia mimosoides (Hatano et al, 1997;Yamamoto et al, 2000), Camelia sinensis (Han et al, 2001), and Salacia reticulate (Yoshikawa, Shimoda, Nishida, Takada, & Matsuda, 2002). In human clinical trials, lipase inhibitors effectively suppressed weight gain in obese patients by reducing the absorption of dietary fat (Drent et al, 1995;Reaven, Segal, Hauptman, Boldrin, & Lucas, 2001;Sternby, Hartmann, Borgsrom, & Nilsson, 2002;Yamamoto et al, 2000).…”

Section: Introductionmentioning

confidence: 99%