Flat Silk Cocoon‐Based Dressing: Daylight‐Driven Rechargeable Antibacterial Membranes Accelerate Infected Wound Healing

Abstract

One of the leading causes of death globally, especially in underdeveloped countries, is bacterial infection. Recently, the prevalence of infections from antibiotic-resistant bacteria has been increasing, which makes the need for innovative antibacterial wound dressings urgent. It is reported that g-C 3 N 4 -based flat silk cocoons (FSCs) with rechargeable antibacterial activity can efficiently generate reactive oxygen species (ROS) under daylight irradiation. The photoactive FSCs store the ROS and then release them in the dark. The engineered FSCs exhibit integrated properties of good biocompatibility, strong mechanical characteristics, robust photoactivity with photostorability, and excellent bactericidal efficiency (99.9% contact killing). In a rat model of infected wounds, the photoactive FSCs induce faster healing and reduce bacterial infections. The successful application of these FSC materials as wound dressings may provide a versatile platform for exploring the use of green photoactive antibacterial materials for accelerated wound healing and prevention of infections.

Sustainable Sources of Raw Materials for Additive Manufacturing of Bone‐Substituting Biomaterials

“…[162] Biomaterials made of silk fibroin (Figure 5b) can aid in the repair of various types of tissues, such as bone [31,163,164] and articular cartilage, [165] including infection prevention and treatment (Figure 5c). [166][167][168]…”

Transparent silk fibroin film-facilitated infected-wound healing through antibacterial, improved fibroblast adhesion and immune modulation

“…[12][13][14] Moreover, RSF can be facilely processed into various forms of hydrogels, sponge, or films for application as a wound dressing. 15 RSF films are the most attractive candidate because of their excellent transparency, thus allowing for efficient wound recovery. [16][17][18][19] Unfortunately, the application of RSF films is restricted by its fragility, which is mainly attributed to its unique secondary structure of predominant rigid b-sheets.…”

Silk Nanofiber Scaffolds with Multiple Angiogenic Cues to Accelerate Wound Regeneration

“…Silk fibroin (SF) is considered a promising biomaterial to develop bioactive wound matrices due to its biocompatibility, biodegradability, tunable mechanical properties, and versatility in modes of material fabrication. − Both SF scaffolds and hydrogels were prepared to stimulate skin regeneration. − The porous structures, aligned topography, and mechanical properties were regulated to endow SF scaffolds/hydrogels with angiogenesic and anti-inflammatory behaviors, favoring better wound repair. − Different drugs and growth factors were also loaded in SF matrices to regulate cell behavior and tissue regeneration. − Although multiple chemical and physical cues improved the bioactivity of SF wound matrices, it is currently difficult to optimize multiple cues simultaneously due to the interplay of these cues in the fabrication processes.…”