Flash Visual Evoked Potentials in Preterm Infants

Feng, Jingjing; Wang, Weiping; Guo, Shujuan; Liu, Zhiwei; Xu, Xiu

doi:10.1016/j.ophtha.2012.08.025

Cited by 10 publications

(11 citation statements)

References 27 publications

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“…These findings help to establish novel outcome measures for translational HIE research or even the development of an artificial intelligence based toolbox for neonatal EEG monitoring. VEPs are also good predictors of neurological functional alterations in newborns [35,36]. Asphyxia resulted in abnormal VEP waveforms altering both signal latency and amplitude in all groups, similar to observations in animal models [37] or human neonates [38].…”

Section: Discussionsupporting

confidence: 72%

Inhaled H2 or CO2 Do Not Augment the Neuroprotective Effect of Therapeutic Hypothermia in a Severe Neonatal Hypoxic-Ischemic Encephalopathy Piglet Model

Kovács

Remzső

Tóth‐Szűki

et al. 2020

IJMS

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Hypoxic-ischemic encephalopathy (HIE) is still a major cause of neonatal death and disability as therapeutic hypothermia (TH) alone cannot afford sufficient neuroprotection. The present study investigated whether ventilation with molecular hydrogen (2.1% H2) or graded restoration of normocapnia with CO2 for 4 h after asphyxia would augment the neuroprotective effect of TH in a subacute (48 h) HIE piglet model. Piglets were randomized to untreated naïve, control-normothermia, asphyxia-normothermia (20-min 4%O2–20%CO2 ventilation; Tcore = 38.5 °C), asphyxia-hypothermia (A-HT, Tcore = 33.5 °C, 2–36 h post-asphyxia), A-HT + H2, or A-HT + CO2 treatment groups. Asphyxia elicited severe hypoxia (pO2 = 19 ± 5 mmHg) and mixed acidosis (pH = 6.79 ± 0.10). HIE development was confirmed by altered cerebral electrical activity and neuropathology. TH was significantly neuroprotective in the caudate nucleus but demonstrated virtually no such effect in the hippocampus. The mRNA levels of apoptosis-inducing factor and caspase-3 showed a ~10-fold increase in the A-HT group compared to naïve animals in the hippocampus but not in the caudate nucleus coinciding with the region-specific neuroprotective effect of TH. H2 or CO2 did not augment TH-induced neuroprotection in any brain areas; rather, CO2 even abolished the neuroprotective effect of TH in the caudate nucleus. In conclusion, the present findings do not support the use of these medical gases to supplement TH in HIE management.

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Section: Discussionsupporting

confidence: 72%

Inhaled H2 or CO2 Do Not Augment the Neuroprotective Effect of Therapeutic Hypothermia in a Severe Neonatal Hypoxic-Ischemic Encephalopathy Piglet Model

Kovács

Remzső

Tóth‐Szűki

et al. 2020

IJMS

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“…Feng et al noticed that latency of the P2 main wave on FVEPs was delayed more significantly in premature infants than in full-term infants [ 27 ]. They ascertained that the visual functional development was delayed in preterm born infants, especially in infants with very low birth weight and in gestational age less than 32 weeks [ 27 , 28 ]. However, FVEP is less precise examination than PVEP; thereby PVEP should be the first ordered testing [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

An Influence of Birth Weight, Gestational Age, and Apgar Score on Pattern Visual Evoked Potentials in Children with History of Prematurity

et al. 2015

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Purpose. The objective of our study was to examine a possible influence of gestational age, birth weight, and Apgar score on amplitudes and latencies of P100 wave in preterm born school-age children. Materials and Methods. We examined the following group of school-age children: 28 with history of prematurity (mean age 10.56 ± 1.66 years) and 25 born at term (mean age 11.2 ± 1.94 years). The monocular PVEP was performed in all children. Results. The P100 wave amplitudes and latencies significantly differ between preterm born school-age children and those born at term. There was an essential positive linear correlation of the P100 wave amplitudes with birth weight, gestational age, and Apgar score. There were the negative linear correlations of P100 latencies in 15-minute stimulation from O1 and Oz electrode with Apgar score and O1 and O2 electrode with gestational age. Conclusions. PVEP responses vary in preterm born children in comparison to term. Low birth weight, early gestational age, and poor baseline output seem to be the predicting factors for the developmental rate of a brain function in children with history of prematurity. Further investigations are necessary to determine perinatal factors that can affect the modified visual system function in preterm born children.

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“…[13] More recently, the clinical utility of VEP in premature neonates has been confirmed by Feng et al . [1415] It is known that the result of VEP depends on retinal development, optic nerve myelination, lateral geniculate nucleus maturation, and occipital cortex development, but there are still some controversies about the influence of ROP on VEP examination results in preterm children. [1617]…”

Section: Discussionmentioning

confidence: 99%

Microstructure changes of occipital white matter are responsible for visual problems in the 3–4-year-old very low birth weight children

Leśniak

Herman‐Sucharska

Klimek

et al. 2017

Indian J Ophthalmol

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Purpose:The main aim of the study was to evaluate which factors affect the long-time visual function in preterm children, whether it is prematurity or retinopathy of prematurity or perhaps disturbances in the visual pathway.Materials and Methods:Fifty-eight children with mean birth weight 1016 g (range 520–1500 g) were evaluated at mean age 48 months (range 42–54 months). All children underwent magnetic resonance imaging (MRI) studies, visual evoked potentials (VEPs), and the Developmental Test of Visual Perception (DTVP). The MRI evaluation included diffusion tensor imaging and fractional anisotropy (FA), and colored orientation maps were calculated for each subject. Based on the results of the VEP evaluation, children were divided into two groups: A-abnormal results of VEP (n = 16) and B-normal VEP results (comparison group, n = 42).Results:FA values of inferior left and right occipital white matter (OWM) were lower in the group of children with abnormal VEP compared to the comparison group (0.34 ± 0.06 vs. 0.38 ± 0.06; P = 0.047; 0.31 ± 0.04 vs. 0.36 ± 0.06; P = 0.007, respectively). Furthermore, there were correlations between the latency (r = −0.35; P = 0.01) and amplitude (r = 0.31; P = 0.02) and FA in OWM. Children with abnormal VEP had lower DTVP scores as compared with children with normal VEP results (88 ± 18 vs. 95 ± 16 points, P = 0.048). Finally, a multivariate logistic regression revealed that FA of the inferior OWM was the only independent risk factor for the abnormal VEP (P = 0.04).Conclusion:Visual perception, VEPs, and white matter microstructural abnormalities in very low birth weight children at the age of 3–4 are significantly correlated.

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Flash Visual Evoked Potentials in Preterm Infants

Cited by 10 publications

References 27 publications

Inhaled H2 or CO2 Do Not Augment the Neuroprotective Effect of Therapeutic Hypothermia in a Severe Neonatal Hypoxic-Ischemic Encephalopathy Piglet Model

Inhaled H2 or CO2 Do Not Augment the Neuroprotective Effect of Therapeutic Hypothermia in a Severe Neonatal Hypoxic-Ischemic Encephalopathy Piglet Model

An Influence of Birth Weight, Gestational Age, and Apgar Score on Pattern Visual Evoked Potentials in Children with History of Prematurity

Microstructure changes of occipital white matter are responsible for visual problems in the 3–4-year-old very low birth weight children

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