Flash Glucose Monitoring Can Accurately Reflect Postprandial Glucose Changes in Healthy Adults in Nutrition Studies

Wong, Tommy Hon Ting; Wan, Jennifer M. F.; Louie, Jimmy Chun Yu

doi:10.1080/07315724.2020.1734990

Cited by 6 publications

(11 citation statements)

References 27 publications

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“…Glucose. Glucose was measured using the Freestyle Libre Pro (Abbott, Alameda, CA), an interstitial CGM that is FDA-approved and validated for the estimation of blood glucose levels (32,33). Glucose levels are recorded by the device at 15-min intervals.…”

Section: Study Measuresmentioning

confidence: 99%

Breaking Up Prolonged Sitting to Improve Cardiometabolic Risk: Dose–Response Analysis of a Randomized Crossover Trial

Duran

Friel

Serafini

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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PurposeSedentary time is ubiquitous in developed nations and is associated with deleterious health outcomes. Physical activity guidelines recommend reductions in sedentary time; however, quantitative guidelines that inform how often and how long sedentary time should be interrupted have not been provided. The purpose of this study was to examine the acute effects of multiple doses of a sedentary break intervention on cardiometabolic risk factors, concurrently evaluating efficacy of varying frequencies and durations of sedentary breaks.MethodsIn a randomized crossover study, middle- and older-age adults (n = 11) completed the following 8-h conditions on five separate days: 1 uninterrupted sedentary (control) condition and four acute (experimental) trials that entailed different sedentary break frequency/duration combinations: every 30 min for 1 min, every 30 min for 5 min, every 60 min for 1 min, and every 60 min for 5 min. Sedentary breaks entailed light-intensity walking. Glucose and blood pressure (BP) were measured every 15 and 60 min, respectively.ResultsCompared with control, glucose incremental area under the curve was significantly attenuated only for the every 30 min for 5-min dose (−11.8[4.7]; P = 0.017). All sedentary break doses yielded significant net decreases in systolic BP from baseline compared with control (P < 0.05). The largest reductions in systolic BP were observed for the every 60 min for 1 min (−5.2 [1.4] mm Hg) and every 30 min for 5 min (−4.3[1.4] mm Hg) doses.ConclusionsThe present study provides important information concerning efficacious sedentary break doses. Higher-frequency and longer-duration breaks (every 30 min for 5 min) should be considered when targeting glycemic responses, whereas lower doses may be sufficient for BP lowering.

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Section: Study Measuresmentioning

confidence: 99%

Breaking Up Prolonged Sitting to Improve Cardiometabolic Risk: Dose–Response Analysis of a Randomized Crossover Trial

Duran

Friel

Serafini

et al. 2023

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Previous studies have shown that glucose levels and platelet counts were also associated with HT [ 7 , 8 , 9 , 10 , 11 ]. Blood glucose levels can reflect physiological stress, metabolism, and nutritional status [ 12 , 13 , 14 ]. In experimental middle cerebral artery occlusion models with reperfusion, high glucose levels induced HT [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Glucose to Platelet Ratio: A Potential Predictor of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke

Chen

Lin

et al. 2022

Brain Sciences

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Glucose and platelet are two easily obtained clinical indicators; the present research aimed to demonstrate their association with hemorrhagic transformation (HT) in acute ischemic stroke (AIS) patients without thrombolytic or thrombectomy therapy. This was a single-center retrospective study. Patients who were diagnosed with HT after AIS were included in the HT group. Meanwhile, using the propensity score matching (PSM) approach, with a ratio of 1:2, matched patients without HT were included in the non-HT group. Serum G/P levels were measured on the first morning after admission (at least eight hours after the last meal). Characteristics were compared between the two groups. Multivariate logistic regression was used to determine the independent relationship between G/P and HT after AIS, with G/P being divided into quartiles. From January 2013 to March 2022, we consecutively included 643 AIS patients with HT (426/643 [66.25%] with HI and 217/643 [33.75%] with PH), and 1282 AIS patients without HT, at the First Affiliated Hospital of Wenzhou Medical University. The HT group had higher G/P levels than the non-HT group (0.04 ± 0.02 vs. 0.03 ± 0.02, p < 0.001). However, there was no difference in G/P levels between HI and PH subgroups (0.04 ± 0.02 vs. 0.04 ± 0.02, p > 0.05). Moreover, the G/P levels were divided into quartiles (Q1 ≤ 0.022; Q2 = 0.023–0.028; Q3 = 0.029–0.039; Q4 ≥ 0.040), with Q1 being settled as the reference layer. After controlling the confounders, multivariate regression analyses showed that the Q4 layer (Q4: G/P ≥ 0.040) was independently associated with elevated HT risk (odds ratio [OR] = 1.85, 95% CI = 1.31–2.63, p < 0.001). G/P levels on admission were independently associated with HT risk in AIS patients. In clinical practice, adequate attention should be paid to AIS patients with elevated G/P levels (G/P ≥ 0.040).

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“…The study was conducted over 15 days, during which 10 24‐hour periods of glucose measurements were captured by an FGMS device (FreeStyle Libre, Abbott Hong Kong; FSL‐FGMS). This device was validated for its ability to capture postprandial changes in blood glucose concentrations in healthy adults 24 . A run‐in was conducted on the first day, right before the intervention, in order to insert the FSL‐FGMS sensor into the upper arm of the subject with a one‐time blood glucose test by finger‐prick for correction of the data if necessary.…”

Section: Methodsmentioning

confidence: 99%

The effect of a low glycaemic index diet on reducing day‐long glycaemia in healthy young adults: A randomized crossover trial

Hon

Wong

Tse

et al. 2020

Diabetes Obesity Metabolism

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Aim: To compare the effect of a low glycaemic index (LGI) diet on reducing day-long glycaemia with a macronutrient-matched high glycaemic index (HGI) diet, using customized meal delivery to ensure compliance. Materials and Methods: We conducted a single-blinded, randomized crossover trial in 14 healthy adults (57% female) with a mean ± SD age of 21.6 ± 1.7 years. A flash glucose monitoring sensor was installed on the subjects on day 1 to capture the interstitial glucose level every 15 minutes for 14 days. Subjects were randomized to receive an LGI (dietary GI = 40) or HGI (dietary GI = 60) diet (three meals and two snacks) from day 2 for 5 consecutive days, followed by a 2-day washout, then switched to the alternative diet for another 5 days. A paired t-test was used to test the differences in the incremental area under the curve (iAUC) of glucose, postprandial glucose (PPG) concentration and maximum postprandial glucose rise (MPGR) between the LGI and HGI periods. Results: Subjects had lower iAUC for average day-long glycaemia during the LGI intervention period compared with the HGI period (mean ± SD, 865 ± 297 vs. 1024 ± 267 mmol x min/L; P = .047). PPG for breakfast and snack 2, and MPGR for breakfast, snack 2 and dinner, were lower in the LGI period. Conclusions: In young healthy adults, following an LGI diet resulted in lower average day-long glycaemia compared with a macronutrient-matched HGI diet. Our results support the use of LGI diets to reduce the risk of developing glucose intolerance. K E Y W O R D S day-long glycaemia, flash glucose monitoring, glycaemic index, postprandial glycaemia 1 | INTRODUCTION Glycaemic index (GI) is the term introduced by Jenkins et al. 1 to indicate how much the available carbohydrates in foods raised blood glucose on a gram for gram basis. Foods with a higher GI are digested and absorbed in a quicker manner, causing a higher postprandial blood glucose excursion in a shorter duration. 1 The shift from traditional diets that are low GI (LGI) to industrialized diets, which are fibre-depleted, energy-dense and nutrient poor, 2 coincides with a drastic increase in the prevalence of obesity, insulin resistance and cardiovascular diseases. 3 Accumulated evidence from acute and long-term studies has confirmed the health benefits of LGI diets, including but not limited to increased satiety, 4 and improvements in postprandial glycaemia, 5 insulin sensitivity, 6 weight control 4,7 and inflammatory biomarkers. 8

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Flash Glucose Monitoring Can Accurately Reflect Postprandial Glucose Changes in Healthy Adults in Nutrition Studies

Cited by 6 publications

References 27 publications

Breaking Up Prolonged Sitting to Improve Cardiometabolic Risk: Dose–Response Analysis of a Randomized Crossover Trial

Breaking Up Prolonged Sitting to Improve Cardiometabolic Risk: Dose–Response Analysis of a Randomized Crossover Trial

Glucose to Platelet Ratio: A Potential Predictor of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke

The effect of a low glycaemic index diet on reducing day‐long glycaemia in healthy young adults: A randomized crossover trial

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