Flare-up of Dermatomyositis Along with Recurrence of Breast Cancer

Abstract

n Abstract: Dermatomyositis is an idiopathic inflammatory myopathy with characteristic cutaneous manifestations. The association between dermatomyositis and malignancy is becoming more clearly delineated. A sort of dermatomyositis is thought to be paraneoplastic syndrome and dermatomyositis may follow clinical course of malignancy. We report a 68-yearold woman with dermatomyositis, whose clinical onset of dermatomyositis was apparently concomitant with breast cancer. Dermatomyositis had settled down and oral steroid could be tapered after the resection of breast cancer. Creatine kinase value was elevated before the detection of the first and second recurrence and in the terminal state. At the second recurrence, skin lesions and creatine kinase value had flared up and immediate metastatic check-up revealed the recurrence. Our case shows dermatomyositis, which was thought to be paraneoplastic syndrome, that followed clinical course of malignancy and suggests immediate check-up is needed for early detection of recurrence when dermatomyositis flares up after the resection of the malignancy. n

Successful resection of liver metastasis detected by exacerbation of skin symptom in a patient with dermatomyositis accompanied by rectal cancer: a case report and literature review

“…Few studies reported recurring cases of DM and other cancers. These reports demonstrated the association between DM symptoms and cancer recurrence in patients with ovarian cancer [15], breast cancer [16], and bladder cancer [17], supporting our findings in colorectal cancer. The present report describes a rare case with a good outcome of resecting liver metastases that were detected early by exacerbation of skin symptoms before annual examination in a patient with DM accompanied by rectal cancer.…”

Dermatomyositis presenting as a paraneoplastic syndrome due to underlying breast cancer

“…It has also been observed that myopathy may relapse in the setting of recurrent malignancy, further supporting a paraneoplastic origin of malignancy-associated DM 10 12. This suggests that appropriate clinical follow-up of patients previously diagnosed with malignancy-associated DM should include observation for evidence of recurrent malignancy as well as for symptoms and signs of recurrent myopathy.…”

Breast Cancer and Dermatomyositis: A Case Study and Literature Review

“…No trends in hormone receptor status were observed in these breast cancer patients with dm. The distribution of triple-negative 8,18 , her2-positive 9,10,12,15,16 , and estrogen or progesterone receptor-positive [12][13][14]16,17 breast cancers was relatively even.…”

“…Most patients were diagnosed with cancer before they were diagnosed with dm; only 6 of the 25 (24%) presented with myositis symptoms first 13,18,19 . The presence of dm was associated with late-stage tumours, 72% of the women (18 of the 25) having presented with stage iii or iv disease 9,10,[12][13][14][15][16][17][18]20 . No trends in hormone receptor status were observed in these breast cancer patients with dm.…”

“…Median age at the time of initial breast cancer diagnosis in the identified cohort was 58 years (range: 39-74 years), and the most common type of breast cancer was invasive ductal carcinoma (12 of 16 patients with available tumour pathology, 75%) [8][9][10][11][12][13][14][15][16][17] . The median time to diagnosis of breast cancer from presentation with dm was 1 month (range: 29-36 months).…”