Flammulinavelutipes Polysaccharides Modulate Gut Microbiota and Alleviate Carbon Tetrachloride-Induced Hepatic Oxidative Injury in Mice

Xu, Yingyin; Zhang, Zhiyuan; Wang, Bo; He, Xiaolan; Tang, Jie; Peng, Weihong; Zhou, Jie; Wang, Yong

doi:10.3389/fmicb.2022.847653

Cited by 10 publications

(6 citation statements)

References 33 publications

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“…The Fuzhuan brick tea polysaccharide contributed to the proliferation of beneficial microbiota, such as Lactobacillus and Akkermansia , and altered the Trp metabolism and elevated the fecal contents of IAld and IAA [ 48 ]. Flammulina velutipes polysaccharides (FVPs) also changed the composition of the gut microbiota, which affected the Trp metabolism [ 49 ]. The low abundance of Escherichia - Shigella , Dubosiella and Allobaculum , along with the enrichment of Muribaculaceae_unclassified , Ralstonia and Rikenellaceae_RC9_gut_group in the gut, which could result in higher Trp metabolite levels, could be detected in yellow wine polyphenolic compound-treated rats [ 50 ].…”

Section: Trp Metabolism In Gut Microbiotamentioning

confidence: 99%

Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis

Gao

Yang

2022

Cells

129

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Tryptophan is an essential amino acid from dietary proteins. It can be metabolized into different metabolites in both the gut microbiota and tissue cells. Tryptophan metabolites such as indole-3-lactate (ILA), indole-3-acrylate (IAC), indole-3-propionate (IPA), indole-3-aldehyde (IAID), indoleacetic acid (IAA), indole-3-acetaldehyde and Kyn can be produced by intestinal microorganisms through direct Trp transformation and also, partly, the kynurenine (Kyn) pathway. These metabolites play a critical role in maintaining the homeostasis of the gut and systematic immunity and also potentially affect the occurrence and development of diseases such as inflammatory bowel diseases, tumors, obesity and metabolic syndrome, diseases in the nervous system, infectious diseases, vascular inflammation and cardiovascular diseases and hepatic fibrosis. They can not only promote the differentiation and function of anti-inflammatory macrophages, Treg cells, CD4+CD8αα+ regulatory cells, IL-10+ and/or IL-35+B regulatory cells but also IL-22-producing innate lymphoid cells 3 (ILC3), which are involved in maintaining the gut mucosal homeostasis. These findings have important consequences in the immunotherapy against tumor and other immune-associated diseases. We will summarize here the recent advances in understanding the generation and regulation of tryptophan metabolites in the gut microbiota, the role of gut microbiota-derived tryptophan metabolites in different immune cells, the occurrence and development of diseases and immunotherapy against immune-associated diseases.

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Section: Trp Metabolism In Gut Microbiotamentioning

confidence: 99%

Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis

Gao

Yang

2022

Cells

129

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“…Oxidative stress is considered the major cause of carbon tetrachloride–induced acute liver injuries (Xu et al, 2022). Glutamic acid, fumaric acid and malic acid are three important intermediates in the tricarboxylic acid (TCA) cycle.…”

Section: Resultsmentioning

confidence: 99%

Comparative analysis of the liver‐protective effects of raw and stir‐fried semen of Hovenia dulcis in rats via gas chromatography–mass spectrometry–based serum metabolomic profiling and chemometrics

Zhu

et al. 2023

Biomedical Chromatography

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In this study, we used a serum metabolomics methodology based on GC coupled with MS (GC–MS) to investigate the liver‐protective effects of raw and stir‐fried semen of Hovenia dulcis in rats models of carbon tetrachloride–induced liver injury. Multivariate statistical analysis, such as principal component analysis and orthogonal partial least squares discriminant analysis, were performed to examine changes in the metabolic state of rats with carbon tetrachloride–induced liver injury, as well as the recovery pattern of rats pretreated with the raw and stir‐fried semen of H. dulcis. Liver tissues were subjected to histopathological examination. A total of 47 biomarkers were predicted to contribute to the dynamic pathological processes in the liver injury, such as phenylalanine, glutamic acid, glycine, arachidonic acid and linoleic acid. Further analysis revealed that pathways associated with phenylalanine, tyrosine and tryptophan biosynthesis, and linoleic acid metabolism were altered in the injured liver, and that pretreatment with raw and stir‐fried semen of H. dulcis abolished the changes in the aforementioned metabolic pathways.

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“…Jeotgalicoccus is positively correlated with insulin concentration in diabetic rats 52 . Atopostipes is enriched in carbon tetrachlorideinduced hepatic injury mice 53 . In summary, these data suggested that common dietary hydrophilic and hydrophilic emulsi ers demonstrated an adverse effect on gut microbiome homeostasis by elevating disease-associated bacterial genera and reducing the relative abundance of bene cial microbiomes.…”

Section: Discussionmentioning

confidence: 99%

Reassessing the safety of dietary emulsifiers through the lens of gut microbiota

Panyod¹,

Chang³

et al. 2023

Preprint

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Dietary emulsifiers have been linked to various diseases. The recent discovery of the role of gut microbiota-host interactions on health and disease warrants the safety reassessment of dietary emulsifiers through the lens of gut microbiota. Hydrophilic (lecithin (LEC), sucrose esters (SUC), carboxymethylcellulose (CMC)) and lipophilic (mono- and diglycerides (MDG)) emulsifiers are common dietary emulsifiers with high exposure levels in the population. This study proved that SUC and CMC induced hyperglycemia and hyperinsulinemia. MDG impaired circulating lipid and glucose metabolism. Both hydrophilic and lipophilic emulsifiers changed the intestinal microbiota diversity and induced gut microbiota dysbiosis. Hydrophilic emulsifiers have no impact on mucus–bacterial interactions, whereas MDG tended to cause bacterial encroachment into the inner mucus layer and enhance inflammation potential by raising circulating lipopolysaccharide. Our findings demonstrated the safety concerns associated with using dietary emulsifiers, suggesting that they could lead to metabolic syndromes.

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Flammulinavelutipes Polysaccharides Modulate Gut Microbiota and Alleviate Carbon Tetrachloride-Induced Hepatic Oxidative Injury in Mice

Cited by 10 publications

References 33 publications

Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis

Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis

Comparative analysis of the liver‐protective effects of raw and stir‐fried semen of Hovenia dulcis in rats via gas chromatography–mass spectrometry–based serum metabolomic profiling and chemometrics

Reassessing the safety of dietary emulsifiers through the lens of gut microbiota

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