Flagellar Propulsion of Sperm Cells Against a Time‐Periodic Interaction Force

Wang, Zihan; Klingner, Anke; Magdanz, Veronika; Hoppenreijs, Merijn W.; Misra, Sarthak; Khalil, Islam S. M.

doi:10.1002/adbi.202200210

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…Using their ultrafast speed, the biofilms can be destroyed in a short time. Sperm cells have also been proven to possess the ability to overcome time‐periodic interaction force, [ 145 ] which makes them promising for penetrating the EPS of biofilms. Sperm‐driven microrobots are a promising option for overcoming biological barriers.…”

Section: Biomedical Applications Of Soft Bio‐microrobotsmentioning

confidence: 99%

Soft Bio‐Microrobots: Toward Biomedical Applications

Wang

Klingner

Magdanz

et al. 2023

Advanced Intelligent Systems

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Soft bio‐microrobots have the potential to execute complex tasks in unexpected and harsh environments of the human body due to their dexterity and flexibility. The architectural designs of soft bio‐microrobots either replicate the motion of natural creatures or capitalize on their motility. Based on this design principle, biologically inspired microrobots that imitate the movements and functions of biological systems, such as starfish, bacteria, and sperm cells, as well as biohybrid microrobots that combine motile micro‐organisms or cells with functional components have been developed. Herein, an overview of the design principles, energy sources, and biomedical applications of existing soft bio‐microrobots is presented. It is shown that the incorporation of externally responsive material enables biologically inspired microrobots to change their shapes and imitate the motion of living organisms under external stimuli, and it is interpreted how biohybrid microrobots are guided through the tactic behavior of microorganisms or cells. Finally, perspectives on key challenges that soft bio‐microrobots must overcome to achieve in vivo biomedical applications are given.

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Section: Biomedical Applications Of Soft Bio‐microrobotsmentioning

confidence: 99%

Soft Bio‐Microrobots: Toward Biomedical Applications

Wang

Klingner

Magdanz

et al. 2023

Advanced Intelligent Systems

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Nature-inspired miniaturized magnetic soft robotic swimmers

Pramanik,

Verstappen,

Onck

2024

Applied Physics Reviews

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State-of-the-art biomedical applications such as targeted drug delivery and laparoscopic surgery are extremely challenging because of the small length scales, the requirements of wireless manipulation, operational accuracy, and precise localization. In this regard, miniaturized magnetic soft robotic swimmers (MSRS) are attractive candidates since they offer a contactless mode of operation for precise path maneuvering. Inspired by nature, researchers have designed these small-scale intelligent machines to demonstrate enhanced swimming performance through viscous fluidic media using different modes of propulsion. In this review paper, we identify and classify nature-inspired basic swimming modes that have been optimized over large evolutionary timescales. For example, ciliary swimmers like Paramecium and Coleps are covered with tiny hairlike filaments (cilia) that beat rhythmically using coordinated wave movements for propulsion and to gather food. Undulatory swimmers such as spermatozoa and midge larvae use traveling body waves to push the surrounding fluid for effective propulsion through highly viscous environments. Helical swimmers like bacteria rotate their slender whiskers (flagella) for locomotion through stagnant viscid fluids. Essentially, all the three modes of swimming employ nonreciprocal motion to achieve spatial asymmetry. We provide a mechanistic understanding of magnetic-field-induced spatiotemporal symmetry-breaking principles adopted by MSRS for the effective propulsion at such small length scales. Furthermore, theoretical and computational tools that can precisely predict the magnetically driven large deformation fluid–structure interaction of these MSRS are discussed. Here, we present a holistic descriptive review of the recent developments in these smart material systems covering the wide spectrum of their fabrication techniques, nature-inspired design, biomedical applications, swimming strategies, magnetic actuation, and modeling approaches. Finally, we present the future prospects of these promising material systems. Specifically, synchronous tracking and noninvasive imaging of these external agents during in vivo clinical applications still remains a daunting task. Furthermore, their experimental demonstrations have mostly been limited to in vitro and ex vivo phantom models where the dynamics of the testing conditions are quite different compared the in vivo conditions. Additionally, multi-shape morphing and multi-stimuli-responsive modalities of these active structures demand further advancements in 4D printing avenues. Their multi-state configuration as an active solid-fluid continuum would require the development of multi-scale models. Eventually, adding multiple levels of intelligence would enhance their adaptivity, functionalities, and reliability during critical biomedical applications.

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Harnessing Flagella Dynamics for Enhanced Robot Locomotion at Low Reynolds Number

Chikere,

Ozkan-Aydin

2024

IEEE Robot. Autom. Lett.

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Flagellar Propulsion of Sperm Cells Against a Time‐Periodic Interaction Force

Cited by 3 publications

References 49 publications

Soft Bio‐Microrobots: Toward Biomedical Applications

Soft Bio‐Microrobots: Toward Biomedical Applications

Nature-inspired miniaturized magnetic soft robotic swimmers

Harnessing Flagella Dynamics for Enhanced Robot Locomotion at Low Reynolds Number

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