The aim of our study was to compare the levels of anxiety, depression, perceived fatigue, attention deficit and hyperactivity disorder (ADHD) in university students who smoke and non-smokers. 302 volunteer university students were included in the study. Anxiety, depression, fatigue and ADHD status were evaluated in the participants. Anxiety, depression, perceived fatigue and ADHD levels were not different between smokers and non-smokers. In the smoker group; high correlation between DSM-IV with ASRS, DSM-IV with anxiety scores; moderate correlation between DSM-IV with Depression, anxiety with depression, ASRS with depression, ASRS with anxiety scores; weak correlation between FSS with Depression, FSS with ASRS, FSS with Anxiety, FSS with DSM-IV was found. In the non-smoking group; moderate correlation between depression with anxiety, depression with DSM-IV, ASRS and DSM-IV, anxiety and DSM-IV scores; weak correlation between depression and ASRS, anxiety and ASRS, depression and FSS, ASRS with FSS, anxiety and FSS, DSM-IV and FSS was found. The study results showed that both anxiety and depression, perceived fatigue levels, ADHD levels and the relationship between the two groups were similar in both groups.