Fixed ratio between radial cortical volume and density measured by peripheral quantitative computed tomography (pQCT) regardless of age and sex

Fujii, Y.; Miyauchi, Akimitsu; Takagi, Yasuyuki; Goto, Bunrei; Fujita, Takeshi

doi:10.1007/bf00298595

Cited by 18 publications

(15 citation statements)

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“…In the present study, CoTh deduced from the propagation time (the time-of-flight) between the transmitting and the receiving transducers for the fast and slow waves showed a similar age range of plateau (from 20-24 to 35-39 years in men and from 20-24 to 45-49 years in women) to that in TBD (from 25-29 to 35-39 years in men and from 20-24 to 45-49 years in women), indicating that the pattern of age-related changes in CoTh resembles that in TBD. The CoTh reportedly decreased about 50% in the 70-79 year age group compared to the 20-29 year age group in Japanese women using a pQCT system [34]. Similarly, CoTh measured by the LD-100 system decreased 48% in the 75-79 year group compared to the 25-29 year group in women, while decreasing 36% during the same age interval in men.…”

Section: Discussionmentioning

confidence: 90%

Novel ultrasonic bone densitometry based on two longitudinal waves: significant correlation with pQCT measurement values and age-related changes in trabecular bone density, cortical thickness, and elastic modulus of trabecular bone in a normal Japanese population

et al. 2010

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Section: Discussionmentioning

confidence: 90%

Novel ultrasonic bone densitometry based on two longitudinal waves: significant correlation with pQCT measurement values and age-related changes in trabecular bone density, cortical thickness, and elastic modulus of trabecular bone in a normal Japanese population

et al. 2010

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“…The clinical application of the first pQCT systems made it possible to provide volumetric densities of both total bone density (BD) and trabecular bone density (TBD) separately and the polar strength strain index (pSSI) in the distal radius [17,18,[20][21][22][23][24][25]. For radial pQCT, the regional specificity concerning vertebral fracture prediction is a priori out of the question, but pQCT provides reliable biomechanical indicators of bone strength that are more adequate for fracture prediction than those offered by DXA [26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Cut-off Values Determined for Vertebral Fracture by Peripheral Quantitative Computed Tomography in Japanese Women

Gorai

Nonaka²,

Kishimoto

et al. 2001

Osteoporos Int

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In spite of the benefits of bone mass measurement by dual-energy X-ray absorptiometry (DXA), the use of DXA has limitations. It is unable to assess a true bone density, and cannot discriminate between the trabecular and cortical bone compartments. Ultradistal radius bone density was measured using peripheral quantitative computed tomography (pQCT) to determine reference values for total bone density (BD), trabecular bone density (TBD), polar strength strain index (pSSI), total bone mineral content (BC), trabecular bone mineral content (TBC), cortical bone density (CBD), cortical bone mineral content (CBC) and polar cross-sectional moment of inertia (pCSMI) in the Japanese female population, and to ascertain the cut-off values of the measured indicators that could most efficiently discriminate osteoporotic subjects with vertebral fractures. A total of 5266 healthy Japanese women aged 20-89 years were included in this study to determine Japanese reference values. Additionally, 621 who had undergone radiographic examination of the thoracic and lumbar spine at the time of pQCT measurement were selected to determine the cut-off values of BD, TBD, pSSI and other indicators for vertebral fractures. All the healthy subjects were divided into 5 year age groups. The BD showed nonsignificant changes from the 20-24 year age group to the 45-49 year age group, and fell significantly thereafter. The TBD maintained a plateau until the 40-44 year group, which corresponds to the young adult mean (YAM) values of the lumbar spine, femoral neck and radius BMDs measured using DXA. The TBD decreased significantly thereafter. The pSSI did not change significantly from the 20-24 year age group to the 45-49 year age group, and decreased slightly in the 50-54 year age group and markedly after 55-59 years. The cut-off values for the discrimination of vertebral fractures were obtained by the calculation of sensitivities, specificities and the area under the curves obtained using age-adjusted receiver operating characteristics (ROC) analysis. Odds ratios and 95% confidence limits (CL) were calculated using age-adjusted logistic analysis. The cut-off values for vertebral fractures, the area under the ROC curves (AUC) and odds ratios were 270.1 mg/cm3 (-2.2 SD, 66.6% of YAM), 0.689+/-0.025, 2.10 (1.63, 2.70) for BD, 104.8 mg/cm3 (-2.2 SD, 53.5% of YAM), 0.699+/-0.023, 2.17 (1.69, 2.77) for TBD and 192.8 mm3 (-1.9 SD, 59.8% of YAM), 0.631+/-0.028, 1.72 (1.34, 2.21) for pSSI, respectively. These findings suggest that ultradistal radius BMD measured using pQCT can be used to discriminate women with vertebral fractures.

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“…Among these, peripheral quantitative computed tomography (pQCT) measures the volumetric and true three-dimensional density of both cortical and trabecular bone separately with a high level of precision [9], which is difficult when using other methods including dual-energy X-ray absorptiometry (DXA). Relative cortical bone volume, or cortical thickness, was measured by pQCT [10][11][12][13], and biomechanical strength of the bone was noninvasively estimated by calculating density distribution as the Strength Strain Index (SSI) [14]. This index represents one factor of cortical bone strength, based on the theory that defines the stability of mechanical bone structures against bending or torsion [14].…”

Section: Introductionmentioning

confidence: 99%

Oral Glucocorticoid-Induced Fall in Cortical Bone Volume and Density in Postmenopausal Asthmatic Patients

et al. 2001

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Despite a deepening understanding of the influence of glucocorticoids (GC) on trabecular bone, little is known about GC-induced cortical bone loss. To elucidate the mechanism of GC-induced loss of cortical bone strength with particular reference to cortical bone loss, changes in cortical density, relative cortical volume, and the Strength Strain Index (SSI) based on biomechanical analyses of the geographic distribution of cortical bone material were measured. These parameters were compared, using peripheral quantitative computed tomography (pQCT), among the following age-matched groups: 68 postmenopausal asthmatic patients receiving high-dose oral GC in addition to inhaled GC (oral GC group), 68 postmenopausal asthmatic patients receiving only inhaled GC (inhaled GC group) and 69 postmenopausal controls without asthma or GC therapy (control group). Cortical bone mineral density (BMD) was measured, relative cortical volume was obtained by dividing the cortical area by the total bone area using pQCT (Stratec XCT960), and the Strength Strain Index (SSI) was calculated in the radius based on the density distribution around the axis. Spinal fracture was assessed on lateral radiographs. The number of vertebral fractures per patient correlated highly with cortical BMD, relative cortical volume and SSI values at the radius. The number of vertebral fractures per patient and the number of patients with fracture were similar between the control and inhaled GC group, both being significantly lower than those in the oral GC group. Total BMD, trabecular BMD, cortical BMD, relative cortical volume and SSI were similar between the first two, being significantly higher than in the last group. The slopes of cortical volume-density relationship, however, were identical among the three groups, indicating the persistence of cortical bone remodeling and a similar degree of calcification regardless of GC administration.

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Fixed ratio between radial cortical volume and density measured by peripheral quantitative computed tomography (pQCT) regardless of age and sex

Cited by 18 publications

References 3 publications

Novel ultrasonic bone densitometry based on two longitudinal waves: significant correlation with pQCT measurement values and age-related changes in trabecular bone density, cortical thickness, and elastic modulus of trabecular bone in a normal Japanese population

Novel ultrasonic bone densitometry based on two longitudinal waves: significant correlation with pQCT measurement values and age-related changes in trabecular bone density, cortical thickness, and elastic modulus of trabecular bone in a normal Japanese population

Cut-off Values Determined for Vertebral Fracture by Peripheral Quantitative Computed Tomography in Japanese Women

Oral Glucocorticoid-Induced Fall in Cortical Bone Volume and Density in Postmenopausal Asthmatic Patients

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