Fixed drug eruptions with intraoral presentation

Srivastava, Rahul; Bihari, Manorama; Jyoti, Bhuvan; Saad, A. Ben

doi:10.4103/0975-962x.154376

Cited by 7 publications

(7 citation statements)

References 16 publications

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“…These lesions typically resolve spontaneously after discontinuation of the causative agent but leave a residual hyperpigmentation at the reaction sites. Repeated exposure to the offending drug may cause new lesions to develop in addition to lighting up the older hyperpigmentation lesions [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Ivermectin-induced fixed drug eruption in an elderly Cameroonian: a case report

2018

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BackgroundCutaneous adverse reactions to medications are extremely common and display characteristic clinical morphology. A fixed drug eruption is a cutaneous adverse drug reaction due to type IV or delayed cell-mediated hypersensitivity. Ivermectin, a broad-spectrum anti-parasitic compound, has been an essential component of public health campaigns targeting the control of two devastating neglected tropical diseases: onchocerciasis (river blindness) and lymphatic filariasis.Case presentationWe report the case of a 75-year-old Cameroonian man of the Bamileke ancestry who developed multiple fixed drug eruptions a few hours following ivermectin intake that worsened with repeated drug consumption. Discontinuation of the drug, counselling, systemic steroids, and orally administered antihistamines were the treatment modalities employed. Marked regression of the lesions ensued with residual hyperpigmentation and dyschromia.ConclusionKeen observation on the part of physicians is mandatory during the administration of ivermectin for quick recognition and prevention of this adverse drug reaction.

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Section: Introductionmentioning

confidence: 99%

Ivermectin-induced fixed drug eruption in an elderly Cameroonian: a case report

2018

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“…It usually occurs within half to 8 hours after the drug is taken. 4 The severity is proportional to the time exposure of the drug and resolves once the offending drug is stopped.…”

Section: Discussionmentioning

confidence: 99%

A case of self-treatment induced oral mucosal fixed drug eruptions associated with use of tinidazole - a case report

Prabhu¹,

Shetty²

2021

Int J Res Med Sci

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Fixed drug eruptions (FDE) is a type of adverse reaction to drugs encountered in medical practice. Skin, glans penis is most common site of involvement. We hereby report a case of fixed drug eruption on oral mucosa due to tinidazole, a nitroimidazole-derivative which the patient had taken as he was suffering from gastro-intestinal distress. Very limited case reports have been found in literature with respect to tinidazole causing FDE.

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“…Other forms of FDE are pigmenting fixed drug eruption, generalized or multiple fixed drug eruption, linear fixed drug eruption, wandering fixed drug eruption, non-pigmenting fixed drug eruption, bullous fixed drug eruption, eczematous fixed drug eruption, urticarial fixed drug eruption, erythema dyschromicum perstans-like fixed drug eruption, vulvitis, oral, psoriasiform, cellulitis like eruption. [30][31][32][33][34]…”

Section: Drugs Causing Fixed Drug Eruptionsmentioning

confidence: 99%

A review on drug induced skin disorders: pathophysiology and therapeutics

Srinivasan

2020

Int J Res Dermatol

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<p class="abstract"><span lang="EN-US">Drugs are the central part of treatment of various disorders. The consequence of drug use may be either positive outcomes (clinical effect of the drug) or negative outcomes (adverse drug events). That is, it contains both risk and benefit. In recent years multiple disorders treated with many drugs by monotherapy or by fixed-dose therapy existing in the market which leads to increased drug-related problems one among that is drug-induced disorders. Morbidity and mortality have increased due to drug-induced disorders. This study was aimed to describe the various drugs induces skin disorders, its pathophysiology, diagnosis and treatment approach. We completed a review of the current evidence for various drug-induced skin disorders its causative drugs and therapeutic intervention of drug-induced skin disorders. A review through Medline, Embase, Pubmed, Wiley online library and selected studies related to drug-induced skin disorders. This is the comprehensive review of drug- induced skin disorders, designed to address prospectively its etiopathogenesis and clinical management. Penicillin, sulfa, phenyl-butazone, Tetracycline are the most common drug induces various skin disorders. There is not much significant differences in the clinical, histopathological or immuno-pathological features between various skin disorders and drug induced skin disorders. Hence knowing the etiopathology, and differential diagnosis is important to a proper treatment approach.</span></p>

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Fixed drug eruptions with intraoral presentation

Cited by 7 publications

References 16 publications

Ivermectin-induced fixed drug eruption in an elderly Cameroonian: a case report

Ivermectin-induced fixed drug eruption in an elderly Cameroonian: a case report

A case of self-treatment induced oral mucosal fixed drug eruptions associated with use of tinidazole - a case report

A review on drug induced skin disorders: pathophysiology and therapeutics

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