Ivermectin-induced fixed drug eruption in an elderly Cameroonian: a case report

Abstract

BackgroundCutaneous adverse reactions to medications are extremely common and display characteristic clinical morphology. A fixed drug eruption is a cutaneous adverse drug reaction due to type IV or delayed cell-mediated hypersensitivity. Ivermectin, a broad-spectrum anti-parasitic compound, has been an essential component of public health campaigns targeting the control of two devastating neglected tropical diseases: onchocerciasis (river blindness) and lymphatic filariasis.Case presentationWe report the case of a 75-year-old Cameroonian man of the Bamileke ancestry who developed multiple fixed drug eruptions a few hours following ivermectin intake that worsened with repeated drug consumption. Discontinuation of the drug, counselling, systemic steroids, and orally administered antihistamines were the treatment modalities employed. Marked regression of the lesions ensued with residual hyperpigmentation and dyschromia.ConclusionKeen observation on the part of physicians is mandatory during the administration of ivermectin for quick recognition and prevention of this adverse drug reaction.

Epidemiological and Clinical Characteristics, Causative Drugs, and Diagnostic Challenges of Fixed Drug Eruption in Elderly Patients: Is Bullous Type a More Common Clinical Phenotype?

“…We assume that this value may further increase in the near future, as the older population continues to grow in Turkey as well. Moreover, although FDE usually has no gender preference, a female predominance in our study (n=9/14; 64.3%) as well as in previously reported elderly cases (n=3/4; 75%) was remarkable (7,(10)(11)(12).…”

“…The inducers of FDE show significant geographical and temporal variations depending on the most frequently used drugs in a given time period (9). Fix drug eruption (FDE) may occur throughout life; however, aside from a few anecdotal case reports, there is lack of data regarding its characteristics in the older population (10)(11)(12).…”

Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19: An EAACI Position Paper

“…Rare case reports of multiple FDEs, 129 confirmed DRESS by skin biopsy and blood eosinophilia, 130 confirmed SJS 131 and TEN 132 by skin biopsy were published (Table 2). No data about STs, in vitro tests, or DPT are available.…”

Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19

“…Rare case reports of multiple FDEs (126), confirmed DRESS by skin biopsy and blood eosinophilia (127), confirmed SJS (128) and TEN (129) by skin biopsy were published. No data about STs, in vitro tests or DPT are available.…”