Fixed drug eruption with ornidazole having cross‐sensitivity to secnidazole but not to other nitro‐imidazole compounds: a case report

Sanmukhani, Jayesh; Shah, Viral N.; Baxi, Seema; Tripathi, C. B.

doi:10.1111/j.1365-2125.2010.03651.x

Cited by 32 publications

(36 citation statements)

References 8 publications

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“…[3] Cross sensitivity tends to occur in other drugs similar in structure to the causative agent. [15] FDE due to thiacetazone was observed in one patient.Mani et al [16] Reported that thiacetazone was the most common antimicrobial drug to cause eruptions. The time latency between application and reaction ranged from ½ hour to 10 hours with a mean of 2.36 hours.…”

Section: Resultsmentioning

confidence: 93%

A Study of Various Drugs Causing Fixed Drug Eruptions

Kamala¹,

M²,

Shirisha³

et al. 2015

jemds

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AIM:To study the pattern of fixed drug eruptions to various drugs and to find out the common drugs causing fixed drug eruptions using provocative tests. 30 patients of FDE were studied. The pattern of fixed drug eruptions, most common class of drug, individual drugs causing positive reaction using provocation tests. Results were analyzed using suitable statistical methods. RESULTS: Drug eruption which is commonest in our study was fixed drug eruption (54.54%). 66.66% of cases had only cutaneous lesions. The commonest site of lesion was over limbs (46.66%). Maximum number of patients showed positive reaction on provocative test with oxyphenbutazone followed by sulphamethoxazole. CONCLUSION: This study helps to investigate the drug causing FDR with particular clinical pattern more accurately, especially those with a multi-drug history. Knowledge of these drug eruptions, the causative drugs and the prognostic indicators is essential for clinicians for diagnosis and prevention of adverse drug reactions. Pharmacovigilance activity is significantly effective in increasing the reporting of ADRs.

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Section: Resultsmentioning

confidence: 93%

A Study of Various Drugs Causing Fixed Drug Eruptions

Kamala¹,

M²,

Shirisha³

et al. 2015

jemds

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“…FDE due to ornidazole in previously documented three cases had involved lips, chest and antero-lateral aspect of thigh. [4][5][6] Our case described here is unique as it involved the intra-oral site of hard palate, a site never associated with FDE, resulting due to use of ornidazole.…”

Section: Discussionmentioning

confidence: 88%

“…The drug is postulated to be acting as a hapten that binds to basal keratinocytes and resulting in the release of lymphokines and antibodies that in turn damage the basal cell layer. 4 On drug intake CD8+ are reactivated to release IFN and cytotoxic granules into the local microenvironment. Mast cells are also believed to contribute to activation of intraepidermal CD8+ cells through the induction of cell adhesion molecules.…”

Section: Discussionmentioning

confidence: 99%

“…All the nitroimidazoles; metronidazole, tinidazole, satranidazole, ornidazole and secnidazole, have a similar nitroimidazole group but different side chains. 4 Only metronidazole and tinidazole have been known to cause FDE and have been included in the list of drugs causing FDE. 1 On eliciting medical history patient revealed that he used to get a similar condition due to tinidazole but not to metronidazole.…”

Section: Discussionmentioning

confidence: 99%

“…3 FDE with skin reactions has been documented in three previously published cases involving ornidazole, a relatively newer 5-nitroimidazole derivative. [4][5][6] We report a rare case of intra-oral FDE induced by ornidazole affecting hard palate, an extremely rare site for FDE, in a 40-year-old male.…”

Section: Introductionmentioning

confidence: 97%

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Mucosal fixed drug eruption in a patient treated with ornidazole

Marya¹,

Sharma²,

Parashar³

et al. 2012

J Dermatol Case Rep

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Background: Therapeutic drugs have been observed to cause a wide spectrum of adverse oral effects such as dry mouth, gingival enlargement, taste disturbance, oral mucosal ulceration, halitosis, etc. Observations:A rare case of intra-oral fixed drug eruption (FDE) induced by ornidazole presenting on the hard palate, an extremely rare site for FDE, in a 40-yearold male is reported. Conclusions:Ornidazole is a relatively newer 5-nitroimidazole derivative commonly prescribed for Amoebic dysentery in developing countries. FDE is a rare adverse drug effect characterized by onset of round/oval, erythematous macules on the skin or mucosa that can be associated with itching and burning sensation. The exact mechanism causing FDE is unknown. (J Dermatol Case Rep. 2012; 6(1): 21-24)

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Current awareness: Pharmacoepidemiology and drug safety

2010

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 23 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Antidiabetic Agents; 21 Contrast Agents; 22 Bone Conservation Agents; 23 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Fixed drug eruption with ornidazole having cross‐sensitivity to secnidazole but not to other nitro‐imidazole compounds: a case report

Cited by 32 publications

References 8 publications

A Study of Various Drugs Causing Fixed Drug Eruptions

A Study of Various Drugs Causing Fixed Drug Eruptions

Mucosal fixed drug eruption in a patient treated with ornidazole

Current awareness: Pharmacoepidemiology and drug safety

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