“…reported a case of FDE on the hard palate due to ornidazole. 7 Herpes simplex virus (HSV) is frequently reactivated in these areas of healthy individuals. 8 Some of the drugs causing FDE include Trimethoprim-Sulphamethoxazole, Fursemide, Tetracycline, Diclofenac Sodium, Ciprofloxacin, Ibuprofen, Metronidazole, Norfloxacin, Aspirin 6 , naproxen sodium, dipyrone, dimenhydrinate, paracetamol 9 , Fluconazole 10 , Paracetamol 11 , Citrizine 12 , Ornidazole 7 and several other drugs and possibly, any other drug could be an implicating agent, making it an important adverse drug reaction that the clinician must be aware of, to treat and more importantly, avoid.…”