Fixed drug eruption masquerading as herpes simplex labialis.

Boyle, J; Moul, B

doi:10.1136/bmj.289.6448.802

Cited by 8 publications

(3 citation statements)

References 1 publication

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“…Bullous FDE has been reported as mimicking either localized bullous pemphigoid or herpes simplex labialis (6). The fixed localization of FDE is a diagnostic hallmark.…”

Section: Discussionmentioning

confidence: 99%

A Young Woman with Recurrent Vesicles on the Lower Lip: Fixed Drug Eruption Mimicking Herpes Simplex

Benedix¹,

Schilling²,

Schaller³

et al. 2008

Acta Derm Venerol

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A 23-year-old woman presented with recurrent herpetiform vesicles of the lower lip, but all diagnostic measures for herpes virus infection including herpes viridae specific PCR were negative. Medical history revealed that she also had chronic recurrent vulvovaginal candidiasis, which had been treated with various regimes, including repetitive applications of fluconazole. Consequently, fluconazole-induced fixed drug eruption was suspected, but skin tests performed with fluconazole remained with-out response. Consecutive repeated oral provocation tests with fluconazole were carried out and resulted in the development of burning herpetiform vesicles of the lower lip. Histopathology revealed a subepidermal and superficial perivascular infiltrate, basal vacuolated and apoptotic keratinocytes, intra-epidermal lymphocytes and intra-epidermal multilocular vesicles. Together with the clinical history and picture, fluconazole-induced fixed drug eruption mimicking labial herpes simplex virus infection was diagnosed. Oral provocation tests with an alternative systemic antifungal treatment, itraconazole, were well tolerated, systemic therapy with itraconazole was initiated, and no further labial vesicles developed.

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“…Bullous FDE has been reported as mimicking either localized bullous pemphigoid or herpes simplex labialis (6). The fixed localization of FDE is a diagnostic hallmark.…”

Section: Discussionmentioning

confidence: 99%

A Young Woman with Recurrent Vesicles on the Lower Lip: Fixed Drug Eruption Mimicking Herpes Simplex

Benedix¹,

Schilling²,

Schaller³

et al. 2008

Acta Derm Venerol

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“…The clinical expression of classic FDE is sufficiently distinctive to form a diagnosis (see above); however, the unusual expression of FDE may be overlooked unless there is a high degree of suspicion 71–77 . There are reports of localized bullous pemphigoid resembling bullous FDE, 212 or FDE masquerading as herpes (simplex) labialis 213 or discoid lupus erythematosus 214 . Similarly, NFDE, where a tendency to resolve completely after the attack is apparent, 26–30,48–50 must be considered in the differential diagnosis.…”

Section: Differential Diagnosismentioning

confidence: 99%

Fixed drug eruption (FDE): changing scenario of incriminating drugs

Sehgal¹,

Srivastava²

2006

Int J Dermatology

106

115

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“…2 Bullous FDEs mimicking herpes simplex virus infection too has been described in the past. 3 FDE is characterized by single or multiple skin lesions that occur at the same site each time a drug is administered. However, the number and size of sites may increase after each exposure.…”

Section: Discussionmentioning

confidence: 99%

Fluconazole induced herpes labialis-like lesions in an adult male

Afonso¹,

Rane²,

Dang³

et al. 2008

amj

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Fluconazole is a bistriazole commonly prescribed for the treatment of various fungal infections caused by yeasts and dermatophytes. However, there have been several reports of rare Adverse Drug Reactions (ADRs) like Fixed Dose Eruption (FDE), Toxic Epidermal Necrolysis and Stevens Johnson Syndrome following oral administration of fluconazole. We report a rare case of fluconazole induced oral mucosal lesions, mimicking herpes labialis, in a 34 year old male patient receiving oral fluconazole for the treatment of allergic fungal sinusitis.

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Fixed drug eruption masquerading as herpes simplex labialis.

Abstract: Bristol Royal Infirmary, Bristol BS2 8HW J BOYLE, MB, MRCP, senior registrar, department of dermatology B MOUL, MPS, staff pharmacist, regional drug information centre Correspondence to: Dr J Boyle.

Cited by 8 publications

References 1 publication

A Young Woman with Recurrent Vesicles on the Lower Lip: Fixed Drug Eruption Mimicking Herpes Simplex

A Young Woman with Recurrent Vesicles on the Lower Lip: Fixed Drug Eruption Mimicking Herpes Simplex

Fixed drug eruption (FDE): changing scenario of incriminating drugs

Fluconazole induced herpes labialis-like lesions in an adult male

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