Fixed drug eruption. A brief review

Korkij, W.

doi:10.1001/archderm.120.4.520

Cited by 112 publications

(96 citation statements)

References 3 publications

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“…FDEs from cardiovascular drugs have been reported for phenytoin and quinidine (Korkij and Soltani, 1984;Sun et al, 1994). Two cases of oral pigmentation associated with quinidine therapy (Birek and Main, 1988) (S for CYP2C9, 3A4; I of CYP2C9, 2D6, 3A4) may represent FDEs.…”

Section: Anti-arrhythmics Class I (Sodium-channel Blockers)mentioning

confidence: 99%

Oral Adverse Drug Reactions to Cardiovascular Drugs

Torpet

Kragelund

Reibel

et al. 2004

Critical Reviews in Oral Biology & Medicine

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A great many cardiovascular drugs (CVDs) have the potential to induce adverse reactions in the mouth. The prevalence of such reactions is not known, however, since many are asymptomatic and therefore are believed to go unreported. As more drugs are marketed and the population includes an increasing number of elderly, the number of drug prescriptions is also expected to increase. Accordingly, it can be predicted that the occurrence of adverse drug reactions (ADRs), including the oral ones (ODRs), will continue to increase. ODRs affect the oral mucous membrane, saliva production, and taste. The pathogenesis of these reactions, especially the mucosal ones, is largely unknown and appears to involve complex interactions among the drug in question, other medications, the patient's underlying disease, genetics, and life-style factors. Along this line, there is a growing interest in the association between pharmacogenetic polymorphism and ADRs. Research focusing on polymorphism of the cytochrome P450 system (CYPs) has become increasingly important and has highlighted the intra-and inter-individual responses to drug exposure. This system has recently been suggested to be an underlying candidate regarding the pathogenesis of ADRs in the oral mucous membrane. This review focuses on those CVDs reported to induce ODRs. In addition, it will provide data on specific drugs or drug classes, and outline and discuss recent research on possible mechanisms linking ADRs to drug metabolism patterns. Abbreviations used will be as follows:

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Section: Anti-arrhythmics Class I (Sodium-channel Blockers)mentioning

confidence: 99%

Oral Adverse Drug Reactions to Cardiovascular Drugs

Torpet

Kragelund

Reibel

et al. 2004

Critical Reviews in Oral Biology & Medicine

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“…They characteristically recur on the same sites each time the drug is administered, with each exposure, however the number of involved sites may increase. 1,2,3 Lesions may occur on the trunk, limbs, genitalia, perianal and perioral areas (Figure 4). Although fixed drug eruption can be caused by many drugs, phenolphthalein found in laxatives is one of the commonest causes 3 , thus this condition is seen more frequently in people who take laxatives.…”

Section: Fixed Drug Eruptionmentioning

confidence: 99%

Review of common cutaneous adverse drug reactions

Motswaledi

2005

South African Family Practice

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“…Fixed drug eruption (FDE) is characterized by single or multiple skin lesions which occur at the same site each time the drug is administered [1]. Lesions are usually round or oval and well defined, however their number and severity may increase after each exposure.…”

Section: Introductionmentioning

confidence: 99%