Fixation of mesh to the peritoneum using a fibrin glue: investigations with a biomechanical model and an experimental laparoscopic porcine model

Schug-Paß, C.; Lippert, H.; Köckerling, F.

doi:10.1007/s00464-009-0509-0

Cited by 27 publications

(7 citation statements)

References 39 publications

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“…To elucidate the fixation strength von TiMesh light with fibrin glue to the peritoneum, Schug-Pass et al [12] carried out a further stamp penetration test with the biomechanical model, using muscle tissue with peritoneum compared to muscle tissue without peritoneum. Here, too, the defect diameter was 45 mm and mesh size 10 × 15 cm.…”

Section: Methodsmentioning

confidence: 99%

“…Another study by Schug-Pass et al [12], involving laparoscopic IPOM operation on a porcine model, aimed to identify whether adequate fixation of TiMesh light to the peritoneum could be achieved with fibrin glue alone. The mesh was positioned in the middle/upper abdomen and fixed to the peritoneum by spray application of 2 ml of fibrin glue (Tissucol/Tisseel).…”

Section: Methodsmentioning

confidence: 99%

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What do we know about titanized polypropylene meshes? An evidence-based review of the literature

Köckerling

Schug-Paß

2013

Hernia

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Purpose Despite the vast selection of brands available, nearly all synthetic meshes for hernia surgery continue to use one or other of three basic materials: polypropylene, polyester and ePTFE. These are used in combination with each other or with a range of additional materials such as titanium, omega 3, monocryl, PVDF and hyaluronate. This systematic review of all experimental and clinical studies is aimed at investigating whether titanized meshes confer advantages over other synthetic meshes in hernia surgery.Materials and methodsA search of the medical literature from 2002 to 2012, as indexed by Medline, was performed, using the PubMed search engine (http://www.pubmed.gov). The search terms were: hernia mesh, titanium coating, lightweight mesh, TiMesh, mesh complications. All papers were graded according to the Oxford hierarchy of evidence.ResultsPatients operated on with the Lichtenstein technique performed using the lightweight titanium-coated mesh have a shorter convalescence than those with the heavy-weight mesh Prolene. For inguinal hernias operated on with the TAPP technique and using a lightweight titanium-coated mesh in comparison to a heavy-weight Prolene mesh, the early postoperative convalescence seems to improve. Titanized meshes do exhibit a negative effect on sperm motility 1 year after a TEP operation, but not after 3 years. The laparoscopic IPOM technique with a titanium-coated polypropylene mesh was associated with less postoperative pain in the short term, lower analgesic consumption and a quicker return to everyday activities compared with the Parietex composite mesh.ConclusionIn clinical studies, the titanium-coated polypropylene mesh shows in inguinal hernia repair certain benefits compared with the use of older heavy-weight meshes.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

What do we know about titanized polypropylene meshes? An evidence-based review of the literature

Köckerling

Schug-Paß

2013

Hernia

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“…The use of fibrin glue on intact peritoneum may not produce a safe fixation [10]. The use polyacrylate glue in our model showed a similar fixation quality compared to staples.…”

Section: Discussionmentioning

confidence: 92%

Development of a dynamic model for ventral hernia mesh repair

Siassi

Mahn

Baumann

et al. 2014

Langenbecks Arch Surg

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IntroductionThe adequate way of mesh fixation in laparoscopic ventral hernia repair is still subject to debate. So far, simulation has only been carried out in a static way, thereby omitting dynamic effects of coughing or vomiting. We developed a dynamic model of the anterior abdominal wall.Materials and methodsAn aluminium cylinder was equipped with a pressure controlled, fluid-filled plastic bag, simulating the abdominal viscera. A computer-controlled system allowed the control of influx and efflux, thus creating pressure peaks of up to 200 mmHg to simulate coughing and 290 mmHg to simulate vomiting. We tested fixation with tacks (Absorbatack, Covidien Deutschland, Neustadt a. D., Germany). The model was controlled for the friction coefficient of the tissue against the mesh and the physiologic elasticity of the abdominal wall surrogate.ResultsThe model was able to create pressure peaks equivalent to physiologic coughs or vomiting. Physiologic elasticity was thereby maintained. We could show that the friction coefficient is crucial to achieve a physiologic situation.The meshes showed a tendency to dislocate with an increasing number of coughs (Fig. 4). Nevertheless, when applied in a plain manner, the meshes withstood more cough cycles than when applied with a bulge as in laparoscopic surgery.ConclusionsThe dynamic movement of the abdominal wall, the friction between tissue and mesh and the way of mesh application are crucial factors that have to be controlled for in simulation of ventral abdominal hernia closure. We could demonstrate that patient specific factors such as the frequency of coughing as well as the application technique influence the long term stability of the mesh.

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“…The e‐PTFE membrane acts as a barrier layer to minimize the tissue adherence to PP mesh. Since the tissue adhesive is only applied between the PP mesh side and the abdominal wall tissue during surgery, the e‐PTFE layer was removed and only the PP meshes were investigated in this study . Sample meshes were cut at dimension of 1 cm × 3 cm, to match the aluminum holders used for lap shear testing (ASTM F2255‐05).…”

Section: Methodsmentioning

confidence: 99%

Surface modification of polypropylene surgical meshes for improving adhesion with poloxamine hydrogel adhesive

Khanna

Luzinov

et al. 2018

J Biomed Mater Res

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Tissue adhesive has notable clinical benefits in hernia repair fixation. A novel poloxamine tissue adhesive was previously shown to successfully bond collagen tissue with adequate adhesive strength. In application related to attachment of polypropylene (PP) mesh, the adhesive strength between the mesh and poloxamine hydrogel adhesive is limited by the hydrophobicity of PP monofilaments and lack of covalent bond formation. The purpose of this study was to compare two different surface modifications [bovine serum albumin (BSA) adsorption and poly-glycidyl methacrylate/ human serum albumin (PGMA/HSA) grafting] of PP mesh for improving the adhesive strength between poloxamine hydrogel adhesive and PP mesh. The PGMA/HSA surface modification significantly improved the adhesive strength for meshes attached with poloxamine hydrogel tissue adhesive compared with unmodified meshes and meshes modified by BSA adsorption. An area of 1 cm 2 adhesive provided for a maximum adhesive strength of 65-70 kPa for meshes modified by PGMA/HSA, 4-13 kPa for meshes modified by BSA, and 22-45 kPa for unmodified meshes. Optical microscopy and infrared spectroscopy (FTIR) confirmed the improved adhesive strength was achieved through mechanical interlock of the hydrogel tissue adhesive into the PP mesh pores and chemical bonding of the albumin after successful PGMA/HSA grafting onto the PP monofilaments.How to cite this article: Lu X, Khanna A, Luzinov I, Nagatomi J, Harman M. 2019. Surface modification of polypropylene surgical meshes for improving adhesion with poloxamine hydrogel adhesive. J Biomed Mater Res

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Fixation of mesh to the peritoneum using a fibrin glue: investigations with a biomechanical model and an experimental laparoscopic porcine model

Abstract: Mesh fixation alone to the undamaged peritoneum in the intraperitoneal region cannot be recommended because of the risk for dislocation. Additional fixation using sutures, tacks, or both is needed until the mesh material is completely integrated.

Cited by 27 publications

References 39 publications

What do we know about titanized polypropylene meshes? An evidence-based review of the literature

What do we know about titanized polypropylene meshes? An evidence-based review of the literature

Development of a dynamic model for ventral hernia mesh repair

Surface modification of polypropylene surgical meshes for improving adhesion with poloxamine hydrogel adhesive

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