Fixation of experimental osteotomies of the distal femur of rabbits with biodegradable material

Abstract

Osteotomies of the distal femur in 19 rabbits were operatively fixed with totally biodegradable implants. Radiographic, histological, microradiographic, and oxytetracycline-labeling studies showing healing of the osteotomy within 6 weeks. The fixation proved stable sufficiently during healing of the osteotomized bone. The osteotomies united without delay and malalignment did not occur, although no external support was used and the rabbits were allowed to walk freely after the operation. Successful use of the biodegradable fixation developed in the present study was reported recently for the treatment of fractures of the ankle.

Degradable polyglycolide rods for the internal fixation of displaced bimalleolar fractures

“…Radiographs, microradiographs, histological studies and oxytetracycline fluorescence techniques were used as methods of investigation. The results indicated that polyglycolide stimulated no greater foreign body reaction as a rod [38] than it did can still be seen as suture material [39]. No displacement occurred when a polyglycolide rod was used to fix an experimental osteotomy [38].…”

“…The results indicated that polyglycolide stimulated no greater foreign body reaction as a rod [38] than it did can still be seen as suture material [39]. No displacement occurred when a polyglycolide rod was used to fix an experimental osteotomy [38]. Within twelve weeks the implant was absorbed and the structure of the cancellous bone largely restored (Fig.…”

Crosslinked polyanhydrides for use in orthopedic applications: Degradation behavior and mechanics

“…Similar losses have been reported for various devices composed of PGA and PLA in vitro as well. 5 In contrast, Figure 6 shows the effect of mass degradation on the tensile modulus of crosslinked poly(MSA) and a crosslinked copolymer of MSA and MCPH. In both systems, the polymers maintained their structural integrity and >70% of their tensile modulus at 50% mass degradation.…”

Fracture fixation with biodegradable rods Forty-one cases of severe ankle fractures

“…Biodegradable implants for fixation of fractures and osteotomies have been successfully used in animals (Greve and Holste 1985, Claes et al 1986, Vainionpaa et al 1986, Eitenmuller et al 1987, Leenslag et al 1987, Vihtonen 1988, and promising clinical results have been obtained in simple displaced unimalleolar and bimalleolar fractures (Rokkanen et al 1985, Bostman et al 1987.…”