Five-year survival for lung cancer patients managed in general hospitals

Grivaux, M; Zureik, Mahmoud; Marsal, L.; Asselain, Bernard; Peureux, M.; Chavaillon, J.; Prudhomme, A.; Carbonnelle, M.; Goarant, E.; Maury, Bertrand; Bedossa, Alexandra; Blanchon, F

doi:10.1016/j.rmr.2008.07.001

Cited by 38 publications

(22 citation statements)

References 8 publications

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“…In the series from west as well as from India, it is reported that 50-70% cases of NSCLC and up to 2/3rd of SCLC usually present in advanced stage (Behera et al, 2004;Blanchon et al, 2006;Govindan et al 2006;Grivaux et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

Malik¹,

Sharma²,

Mohanti³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Lung cancer is one of the commonest and most lethal cancers throughout the world. The epidemiological and pathological profile varies among different ethnicities and geographical regions. At present adenocarcinoma is the commonest histological subtype of non-small cell lung cancer (NSCLC) in most of the Western and Asian countries. However, in India squamous cell carcinoma has been reported as the commonest histological type in most of the series. The aim of the study was to analyze the current clinico-pathological profile and survival of lung cancer at our centre. Materials and Methods: We analyzed 434 pathologically confirmed lung cancer cases registered at our centre over a period of three years. They were evaluated for their clinical and pathological profiles, treatment received and outcome. The available histology slides were reviewed by an independent reviewer. Results: Median age was 55 years with a male:female ratio of 4.6:1. Some 68% of patients were smokers. There were 85.3% NSCLC and 14.7% SCLC cases. Among NSCLCs, adenocarcinoma was the commonest histological subtype after the pathology review. Among NSCLC, 56.8% cases were of stage IV while among SCLC 71.8% cases had extensive stage disease. Some 29% of patients did not receive any anticancer treatment. The median overall and progression free survivals of the patients who received treatment were 12.8 and 7.8 months for NSCLC and 9.1 and 6.8 months for SCLC. Conclusions: This analysis suggests that adenocarcinoma may now be the commonest histological subtype also in India, provided a careful pathological review is done. Most of the patients present at advanced stage and outcome remains poor.

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Section: Discussionmentioning

confidence: 99%

Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

Malik¹,

Sharma²,

Mohanti³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…This delay in presentation may be attributed to poor knowledge of the disease, less medical attention seeking, ignorance, misdiagnosis, poor referral to speciality centres and lack of preventive measures. In the series from west as well as from India, it is reported that 50-70% cases of NSCLC and up to 2/3rd of SCLC usually present in advanced stage (Becket, 1993;Govindan et al, 2006;Grivaux et al, 2011;Malik et al, 2013). …”

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confidence: 99%

Clinico-pathology of Lung Cancer in a Regional Cancer Center in Northeastern India

Mandal¹,

Singh²,

Sharma³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Thirdly, the performance status was not included in our survival analyses because not all patients included in this study had their performance status recorded in their medical records. However, the association of the performance status and OS has not been consistently demonstrated in the literature [26–28]. Poor performance status can, in some cases, be due to high tumor burden [26].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of quantitative PET/CT in patients with a nonsmall cell lung cancer and another primary cancer

Zhu

Liao

Penney

et al. 2017

Nuclear Medicine Communications

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Objective The staging and management of patients with newly diagnosed non-small cell lung cancer (NSCLC) in the setting of recently diagnosed other (metachronous or synchronous) primary cancer are challenging. This retrospective cohort study was conducted to test our hypothesis that baseline FDG PET/CT parameters, including whole-body metabolic tumor volume (MTVWB), total lesion glycolysis (TLGWB) and maximum standardised uptake value (SUVmaxWB) are associated with overall survival (OS) of such patients. Materials and Methods A total of 110 NSCLC patients (52 men and 58 women, aged 68.6 ± 7.8 years) with other primary malignant cancers who had baseline FDG PET/CT scans were retrospectively reviewed. MTVWB, TLGWB and SUVmaxWB were measured. Kaplan-Meier analysis with the log-rank test and Cox regression models were used to assess the association of OS with FDG PET/CT parameters and clinical risk factors. Results Kaplan-Meier analysis and univariate Cox regression models demonstrated significant associations of OS with ln(MTVWB), ln(TLGWB), ln(SUVmaxWB), TNM stage, and treatment type (surgery versus no treatment). Multivariable Cox regression models showed a significant relationship of OS with ln(MTVWB) (HR = 1.368, P = 0.001), ln(TLGWB) (HR = 1.313, P < 0.001) and ln(SUVmaxWB) (HR = 1.739, P = 0.006), adjusted for age, treatment type, tumor histology, and TNM stage. TNM stage was not significantly associated with OS when MTVWB, TLGWB or SUVmaxWB were included in the multivariable models. Conclusion MTVWB, TLGWB, and SUVmaxWB from baseline FDG PET/CT are individually associated with OS of patients with both NSCLC and other primary malignant tumors; independent on age, treatment type, tumor histology and TNM stage.

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Five-year survival for lung cancer patients managed in general hospitals

Cited by 38 publications

References 8 publications

Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India

Clinico-pathology of Lung Cancer in a Regional Cancer Center in Northeastern India

Prognostic value of quantitative PET/CT in patients with a nonsmall cell lung cancer and another primary cancer

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