Five-year post vaccination efficacy of hepatitis B vaccine in rural Nigeria

Odusanya, Olumuyiwa O.; Alufohai, Ewan F; Meurice, François; Ahonkhai, Vincent I.

doi:10.4161/hv.7.6.14990

Cited by 21 publications

(20 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, in children with an anti-HBs titer < 10 mUI/ml, 68 (81%) of them were aged over 18 months of age suggesting a rapid wane of the anti-HBs titer after vaccination. Our results are consistent with most studies carried out in Sub-Saharan Africa settings [19][20][21]. In contrast, Ouedraogo et al found a seroprotection of 90% in children in Ouagadougou [11] which is close to the high vaccine-induced HBV-protection rate (90-95%) observed among children living in western countries [22].…”

Section: Discussionsupporting

confidence: 92%

Hepatitis B vaccination in Burkina Faso: prevalence of HBsAg carriage and immune response in children in the western region

Sanou

Ilboudo

Mèda

et al. 2018

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Hepatitis B virus (HBV) infection remains a major health problem in Burkina Faso. To control and prevent HBV infection, Hepatitis B vaccine was introduced in the national expanded program in 2006. In this study, we evaluated the prevalence of HBsAg in children aged under 10 years after one decade of universal hepatitis B vaccination, and the immune response among these children. Methodology: Between May and October 2015, a cross-sectional study was conducted among children in two primary healthcare centers in the western region of Burkina Faso. Participants were enrolled in Accart-Ville Healthcare Center in Bobo-Dioulasso (urban area) and the Healthcare Center of the village of Djigouera (rural area). Blood samples were collected from all children and analysed for the presence of HBsAg and anti-HBs antibodies (Abs). For HBsAg positive children, blood samples were also taken among their mothers for screening for HBsAg. Results: A total of 265 children were included in this study. The mean age was 4.4 years. HBsAg was found in 3.4% (9/265) of children. Of the 9 HBsAg positive children, 5 had HBsAg positive mothers. From the 265 children tested for quantification of anti-HBs Ab titer, 219 (82.6%) were fully vaccinated and 135 (61.6%) of them had an anti-HBs ≥ 10 mIU/mL. Conclusion: Despite a good vaccination coverage (82.6%), a considerable proportion of vaccinated children remains unprotected from HBV infection. That emphasizes the need for further strengthening of the vaccination program through implementing the birth dose of HBV vaccine as recommended by WHO.

show abstract

Section: Discussionsupporting

confidence: 92%

Hepatitis B vaccination in Burkina Faso: prevalence of HBsAg carriage and immune response in children in the western region

Sanou

Ilboudo

Mèda

et al. 2018

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…However, the prevalence rate of 4.8% for HBV infection (HBsAg) among the HIV naïve participants is in keeping with previously documented prevalence rates of 3.1%, 4.3%, and 3.9% in Southern Nigeria [41][42][43]. This study including the aforementioned ones was reported after the implementation of HBV vaccination and thus the finding could be attributable to the success of the inclusion of hepatitis B vaccination into the national program on immunization (NPI) schedule in our country, buttressing the fact that HBV infection (both acute and chronic infection) has been on the downward trend in Nigeria [42,44].…”

Section: Plos Onementioning

confidence: 74%

Prevalence of and risk factors for hepatitis B and C viral co-infections in HIV infected children in Lagos, Nigeria

et al. 2020

View full text Add to dashboard Cite

Introduction The study was carried out to determine the prevalence of and risk factors for hepatitis B and C viral co-infections in HIV infected children in Lagos. Method A cross-sectional study conducted to determine the prevalence and risk factors for hepatitis B and C viral co-infection in children aged 2 months to 13 years. There were 187 HIV infected and 187 HIV naïve age, sex-matched controls. Blood samples of participants were assayed for the serologic markers [HBsAg, anti-HBc, and anti-HCV)] of HBV and HCV viral infections using the Enzyme-Linked Immunosorbent assay (ELISA) method. Result The prevalence of HBV infection using HBsAg was 5.3% and 4.8% (p = 0.814), among HIV-infected and HIV naïve children respectively, while using anti-HBc the prevalence was 7.0% and 7.5% (p = 0.842) among HIV- infected and HIV naïve children respectively. The prevalence of HCV infection among HIV- infected and HIV naive children were equal to 0.5% (p = 1.000). There was also no significant association with the identifiable risk factors (sharing of a toothbrush, sharing of needles, incision marks/tattoo, hepatitis B immunization status, history of blood transfusion, previous surgical operation, sexual exposure/abuse, history of jaundice, and genital circumcision) and the HBV and or HCV status among both groups of children. History of sexual exposure/abuse and history of jaundice were however found to be predictors of the presence of HBsAg among HIV infected children only, using a binary logistic regression model. Conclusion The prevalence of HBV and or HCV infection among HIV-infected children is similar to the prevalence among HIV naïve children, suggesting that HIV-infected children are not more predisposed to viral hepatitis than healthy children. Also, there was no significant difference in the prevalence of HBV infection irrespective of the use of HBsAg or anti-HBc.

show abstract

“…Screening and vaccination of students during the first year of study is recommended since HBV vaccine has been shown to be protective. [4,5] We propose further studies to identify factors associated with the spread of hepatitis B in Nigeria. We think our result may not reflect the true prevalence of HBV amongst students since HBsAg marker is not detected during the window period of the infection.…”

Section: Research Lettermentioning

confidence: 98%

Prevalence of hepatitis B virus surface antigen among healthy asymptomatic students in a Nigerian University

et al. 2013

View full text Add to dashboard Cite

Five-year post vaccination efficacy of hepatitis B vaccine in rural Nigeria

Cited by 21 publications

References 14 publications

Hepatitis B vaccination in Burkina Faso: prevalence of HBsAg carriage and immune response in children in the western region

Hepatitis B vaccination in Burkina Faso: prevalence of HBsAg carriage and immune response in children in the western region

Prevalence of and risk factors for hepatitis B and C viral co-infections in HIV infected children in Lagos, Nigeria

Prevalence of hepatitis B virus surface antigen among healthy asymptomatic students in a Nigerian University

Contact Info

Product

Resources

About