Five-Year Follow-Up Study of Choroidal and Ciliary Body Melanomas After Enucleation

Kakebeeke-Kemme, H. M.; Oosterhuis, J. A.; Wolff-Rouendaal, D. De

doi:10.1007/978-94-009-5520-2_2

Cited by 4 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22,[45][46][47][48] For tumor treatment, we combined TTT with 106 Ru plaque treatment, because in 51% to 64% intrascleral and in 11% to 13% episcleral, tumor cells are found that may be a source of local and extrascleral outgrowth. 36,[49][50][51][52] The incidence of tumor recurrence after transscleral melanoma resection was significantly higher in eyes without than with adjuvant plaque radiotherapy. 53 The high incidence of tumor recurrence with extraocular tumor extension after melanoma resection 53 and after photocoagulation treatment 54 supposedly originate from intrascleral tumor cells.…”

Section: Commentmentioning

confidence: 99%

Transpupillary Thermotherapy

Oosterhuis¹,

Korver²,

Keunen³

1998

Arch Ophthalmol

111

View full text Add to dashboard Cite

To evaluate the efficacy and safety of transpupillary thermotherapy in treating choroidal melanoma. Methods and Patients: To perform transpupillary thermotherapy, infrared diode laser energy at 810 nm was used with a beam diameter of about 3 mm and 1-minute exposure time. All 50 patients had choroidal melanoma. We performed transpupillary thermotherapy in 21 tumors that had responded insufficiently to 800 Gy ruthenium 106 brachytherapy; it was combined with 800 Gy 106 Ru brachytherapy for 10 tumors greater than 5 mm in height and with 600 Gy for 19 tumors 5 mm or less in height. Results: Allbut1tumorexhibitedreductionintumorheight within a mean follow-up of 20.5 months (range, 6-49 months). In 41 eyes (82%), the tumor flattened completely. Visual acuity was 20/60 or better in 43 eyes (86%) before treatment and in 14 eyes (28%) at the last examination because of radiation vasculopathy. Neovascular glaucoma developed in 1 eye, and total retinal detachment developed in 2 eyes. Tumor recurrence was observed in 1 patient. Conclusions: Although long-term results are necessary to properly appraise this new therapy, transpupillary thermotherapy may be useful as a complementary modality to brachytherapy.

show abstract

Section: Commentmentioning

confidence: 99%

Transpupillary Thermotherapy

Oosterhuis¹,

Korver²,

Keunen³

1998

Arch Ophthalmol

111

View full text Add to dashboard Cite

show abstract

“…If heat treatment is performed as sole therapy, effective treatment of the sclera over the tumour is as important as treatment of the tumour itself because intra- and episcleral tumour invasion is present in, respectively, 55.7% and 8.2% of patients with medium and large tumours 5. In a group of 21 patients with enucleated small melanomas, 17 showed scleral ingrowth on histopathological examination 6. Intrascleral melanoma cells surviving treatment might be a focus for tumour recurrence, which is associated with a two to threefold higher risk of metastasis.…”

mentioning

confidence: 98%

Transpupillary thermotherapy of choroidal melanoma with or without brachytherapy: a dilemma

Keunen

Korver

Oosterhuis

1999

British Journal of Ophthalmology

View full text Add to dashboard Cite

“…5 In a group of 21 patients with enucleated small melanomas, 17 showed scleral ingrowth on histopathological examination. 6 Intrascleral melanoma cells surviving treatment might be a focus for tumour recurrence, which is associated with a two to threefold higher risk of metastasis. This is evident from the results after photocoagulation treatment of choroidal melanomas showing a high rate of tumour regrowth.…”

mentioning

confidence: 99%