Five-Year Evolution of Basal Laminar Drusen Combined With VitelliformMacular Detachment

Meunier, Isabelle

doi:10.1001/archopht.122.10.1566

Cited by 5 publications

(1 citation statement)

References 3 publications

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“…In all eyes, there was central hyper-autofluorescence on FAF imaging, and accumulated hyper-reflective material on OCT. 9 Therefore, cases of cuticular drusen may develop vitelliform macular detachments with subretinal hyper-reflective material. 12,13 Sakurada et al have classified cuticular drusen into three phenotypes: (1) cluster of numerous small lesions densely populated in the central macula (similar to the original description by Gass et al) 5,11 ; (2) translucent yellowish lesions scattered in posterior pole and extending towards the periphery; and (3) cuticular drusen along with large drusen (mixed variety). Our patient had phenotype 3 cuticular drusen, which have a high risk of developing complications (either geographic atrophy or MNV) compared to phenotype 1 (classical variety).…”

Section: Discussionmentioning

confidence: 91%

Clear subretinal fluid in a case of non-neovascular early-onset drusen: Swept-source imaging evaluation

Agarwal

Handa

Querques

et al. 2020

European Journal of Ophthalmology

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A 50-year-old male presented with recent metamorphopsia in the right eye. Fundus examination revealed bilateral multiple cuticular drusen along with few large colloid drusen (phenotype 3 cuticular drusen). No vitelliform material was evident in the macula in either eye. Fluorescein angiography (FA), indocyanine green angiography (ICGA) did not demonstrate a macular neovascularization (MNV) in either eye. Swept-source optical coherence tomography (SS-OCT) revealed sub-retinal pigment epithelial (RPE) drusen and a clear space beneath the inter-digitation zone and above the RPE-Bruch’s complex. SS-OCTA did not reveal MNV in either eye. The patient was kept under observation, and follow-up at 3 months did not reveal any structural change. Among patients with early-onset drusen, vitelliform detachments may occur due to accumulation of yellow pseudo-vitelliform material. However, serous detachments with an “optically clear” subretinal space can occur by the same mechanism without MNV. Such patients do not merit therapy with anti-vascular endothelial growth factor agents.

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Section: Discussionmentioning

confidence: 91%