Extensive Macular Atrophy with Pseudodrusen-like Appearance: A New Clinical Entity

The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD

“…Zweifel et al, using optical coherence tomography (OCT), showed that these deposits were located in the subretinal space (Zweifel et al, 2010) which have been confirmed by histopathological analysis (Rudolf et al, 2008; Sarks et al, 2011). While long ignored in part, because they can be challenging to visualize on clinical exam, reticular pseudodrusen are now a fundamental criteria for diagnosing and monitoring AMD progression due to improvements in imaging modalities such as OCT and fundus autofluorescence, and recognition that these lesions are a marker for disease advancement (Arnold et al, 1995; Cohen et al, 2007; Hamel et al, 2009; Lee et al, 2012; Zweifel et al, 2010). While the pathogenesis of these lesions is unknown, unesterified cholesterol, apolipoprotein E, CFH, and vitronectin have been found in reticular pseudodrusen (Rudolf et al, 2008).…”

The Relationship Between Pseudodrusen and Choroidal Thickness

“…The association between pseudodrusen appearance and the development of late AMD has been emphasized in numerous studies, [5][6][7][8][9] and they have been demonstrated to represent an independent risk factor for late AMD in a case-control study. The association between pseudodrusen appearance and the development of late AMD has been emphasized in numerous studies, [5][6][7][8][9] and they have been demonstrated to represent an independent risk factor for late AMD in a case-control study.…”

Outer Retinal Atrophy After Regression of Subretinal Drusenoid Deposits as a Newly Recognized Form of Late Age-Related Macular Degeneration

“…The remaining portion of the specimen, the RPE and choroid, did not seem to show any particular sign of pseudodrusen, so the authors hypothesized that the pseudodrusen appearance originated from a thinning choroid. 6,[9][10][11][12] Sarks et al 13 reported a second case of histology of pseudodrusen, but this time, the retina was not lost. 7 This observation was in vivo support of a previous histologic description of subretinal lipoprotein debris occurring in aggregates under the retina in autopsy eyes with no available clinical history.…”