Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production

Yang, Bing‐You; Guo, Rui; Li, Ting; Liu, Yan; Wang, Changfu; Shu, Zunpeng; Wang, Zhibin; Zhang, Jing; Xia, Yueyuan; Jiang, Hai; Wang, Qiuhong; Kuang, Hai‐Xue

doi:10.3390/molecules19044548

Cited by 34 publications

(18 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dmetelins A-D, and 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide isolated from the leaves of Datura metel were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Compounds, dmetelin A, D and 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide, showed significant inhibitory activities, and compounds dmetelin B and C showed moderate inhibitory activities with IC 50 values of 17.8, 11.6, 14.9, 33.3 and 28.6 μM, respectively [84].The aqueous extracts of Datura fastuosa leaves and seeds were evaluated for the analgesic effect on acetic acid-induced writhing and hot plate reaction in mice. The results revealed that Datura fastuosa leaves and seeds extracts at doses of 400 and 800 mg/kg orally induced analgesic effects.…”

Section: Antiinflammatory Analgesic and Antipyretic Effectsmentioning

confidence: 99%

Medical importance of Datura fastuosa (syn: Datura metel) and Datura stramonium - A review

Al-Snafi¹

2017

IOSRPHR

View full text Add to dashboard Cite

Abstract:-The preliminary phytochemical investigation was performed on methanolic and hydroalcoholic extract of Datura fastuosa (syn: Datura metel) revealed the presence of alkaloids, tannins, cardiac glycosides, flavonoids, carbohydrates, amino acids and phenolic compounds, while, phytochemical analysis of Datura stramonium showed that it contained alkaloids, saponins, tannins, steroids, flavonoids, phenols and glycosides. The previous pharmacological studies of Datura fastuosa showed that it possessed antimicrobial insecticidal, antidiabetic, cytotoxic, antioxidant, antiinflammatory, analgesic, antipyretic, neurological, wound healing, reproductive and antispasmodic, while Datura stramonium exerted Antiepileptic, Anti-asthmatic, analgesic, antioxidant, antimicrobial, insecticidal, repellent and organophosphate protective effects. The current review highlights the chemical constituents and pharmacological effects of Datura fastuosa and Datura stramonium.

show abstract

Section: Antiinflammatory Analgesic and Antipyretic Effectsmentioning

confidence: 99%

Medical importance of Datura fastuosa (syn: Datura metel) and Datura stramonium - A review

Al-Snafi¹

2017

IOSRPHR

View full text Add to dashboard Cite

show abstract

“…The residue was dissolved in 1 mL pyridine and 0.7 mL silylation-derived agent, and added to the solution for shaking for 5 min, then placed at room temperature for 4 h, and 1.5 mL distilled water was added. After centrifugation, the supernatant was detected by gas chromatography (GC) [ 5 , 6 ]. The glycosyl configurations of compounds 1 – 4 were determined by the same retention time ( t R ) of standard d -fructose ( t R = 6.3 min) for compounds 1 – 3 , and d -galactose and d -glucose for compound 4 ( t R = 32.5 min and t R = 16.8 min).…”

Section: Experimental Methodsmentioning

confidence: 99%

Four New Glycosides from the Rhizoma of Anemarrhena asphodeloides

Yang

Liu

et al. 2017

Molecules

Self Cite

View full text Add to dashboard Cite

Four new compounds, aneglycoside A–C (1–3) and timosaponin U (4), were isolated from the rhizomes of Anemarrhena asphodeloides. Their structures were determined through extensive spectroscopic analysis, chemical characteristics, and high-resolution mass spectrometry (HRMS). All the isolations were evaluated for cytotoxicity against HepG2, Hela, and SGC7901 human cancer lines. Compounds 1, 2, and 4 showed weak antiproliferative activities on HepG2, Hela, and SGC7901 cells.

show abstract

“…All the standard substances were isolated and purified by our laboratory [4,5,21,[27][28][29] (Figure 4). UPLC analysis determined that the purity of all target compounds was above 98%.…”

Section: Chemical Reagents Equipment and Standard Solutionsmentioning

confidence: 99%

UPLC-MS/MS Identification and Quantification of Withanolides from Six Parts of the Medicinal Plant Datura Metel L.

et al. 2020

Self Cite

View full text Add to dashboard Cite

Withanolides from six parts (flower, leaf, stem, root, seed, and peel) of Datura metel L. (D metel L.) obtained from ten production areas in China were identified and quantified by UPLC-MS/MS. A total of 85 withanolides were characterized for the first time using the UPLC-Q-TOF-MS/MS system. Additionally, a simultaneous, rapid and accurate measurement method was developed for the determination of 22 bioactive withanolides from ten production areas with the UPLC-Q-TRAP-MS/MS system. The results show the total withanolide content is highest in the leaves (155640.0 ng/g) and lowest in the roots (14839.8 ng/g). Compared with other production areas, the total content of plants from Dujiangyan was the highest at 82013.9 ng/g (value range of ten areas: 82013.9–42278.5 ng/g). The results also show significant differences in the distribution of withanolides in the different plant parts, as well as across different production areas. This is a breakthrough report providing a simultaneous qualitative and quantitative analysis of 22 withanolides in D. metel L. It could be the basis for the more rational use of various parts of D. metel L., and the expansion of medicinal resources. This work also lays a solid foundation for research on the quality control of D. metel L.

show abstract

Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production

Cited by 34 publications

References 28 publications

Medical importance of Datura fastuosa (syn: Datura metel) and Datura stramonium - A review

Medical importance of Datura fastuosa (syn: Datura metel) and Datura stramonium - A review

Four New Glycosides from the Rhizoma of Anemarrhena asphodeloides

UPLC-MS/MS Identification and Quantification of Withanolides from Six Parts of the Medicinal Plant Datura Metel L.

Contact Info

Product

Resources

About