Abstract:Learning Objectives: After studying this article and accompanying videos, the participant should be able to: 1. Understand and apply the principles of nerve transfer surgery for nerve injuries. 2. Discuss important considerations when performing nerve transfers, such as aspects of surgical technique and perioperative decision-making. 3. Understand indications for end-to-end versus supercharged reverse end-to-side nerve transfers. 4. Understand an algorithm for treating nerve injuries to include the indications… Show more
“…The C also led to superior recovery of motor and sensory function [377][378][379][380][381][382][383][384][385]. The auth pointed out that CES could be applied in delayed repair of chronic nerve injuries a major polytrauma that necessitates emergency life or limb management [Section 3], most require two consecutive surgeries for electrode placement prior to surgical rep The same issue arises in distal nerve transfer surgery where a 'donor' nerve branch o redundant muscle is cut and sutured to the distal stump of a non-functional 'recipie nerve to restore function [386][387][388][389][390][391]. Oberlin's transfer to restore elbow flexion is a clas example with a transected ulnar nerve fascicle supplying the flexor carpi ulnaris mus sutured to the distal stump of the musculocutaneous nerve branch to biceps brachii m cle [386].…”
Section: Conditioning Lesion and Conditioning Esmentioning
Injured peripheral nerves regenerate their axons in contrast to those in the central nervous system. Yet, functional recovery after surgical repair is often disappointing. The basis for poor recovery is progressive deterioration with time and distance of the growth capacity of the neurons that lose their contact with targets (chronic axotomy) and the growth support of the chronically denervated Schwann cells (SC) in the distal nerve stumps. Nonetheless, chronically denervated atrophic muscle retains the capacity for reinnervation. Declining electrical activity of motoneurons accompanies the progressive fall in axotomized neuronal and denervated SC expression of regeneration-associated-genes and declining regenerative success. Reduced motoneuronal activity is due to the withdrawal of synaptic contacts from the soma. Exogenous neurotrophic factors that promote nerve regeneration can replace the endogenous factors whose expression declines with time. But the profuse axonal outgrowth they provoke and the difficulties in their delivery hinder their efficacy. Brief (1 h) low-frequency (20 Hz) electrical stimulation (ES) proximal to the injury site promotes the expression of endogenous growth factors and, in turn, dramatically accelerates axon outgrowth and target reinnervation. The latter ES effect has been demonstrated in both rats and humans. A conditioning ES of intact nerve days prior to nerve injury increases axonal outgrowth and regeneration rate. Thereby, this form of ES is amenable for nerve transfer surgeries and end-to-side neurorrhaphies. However, additional surgery for applying the required electrodes may be a hurdle. ES is applicable in all surgeries with excellent outcomes.
“…The C also led to superior recovery of motor and sensory function [377][378][379][380][381][382][383][384][385]. The auth pointed out that CES could be applied in delayed repair of chronic nerve injuries a major polytrauma that necessitates emergency life or limb management [Section 3], most require two consecutive surgeries for electrode placement prior to surgical rep The same issue arises in distal nerve transfer surgery where a 'donor' nerve branch o redundant muscle is cut and sutured to the distal stump of a non-functional 'recipie nerve to restore function [386][387][388][389][390][391]. Oberlin's transfer to restore elbow flexion is a clas example with a transected ulnar nerve fascicle supplying the flexor carpi ulnaris mus sutured to the distal stump of the musculocutaneous nerve branch to biceps brachii m cle [386].…”
Section: Conditioning Lesion and Conditioning Esmentioning
Injured peripheral nerves regenerate their axons in contrast to those in the central nervous system. Yet, functional recovery after surgical repair is often disappointing. The basis for poor recovery is progressive deterioration with time and distance of the growth capacity of the neurons that lose their contact with targets (chronic axotomy) and the growth support of the chronically denervated Schwann cells (SC) in the distal nerve stumps. Nonetheless, chronically denervated atrophic muscle retains the capacity for reinnervation. Declining electrical activity of motoneurons accompanies the progressive fall in axotomized neuronal and denervated SC expression of regeneration-associated-genes and declining regenerative success. Reduced motoneuronal activity is due to the withdrawal of synaptic contacts from the soma. Exogenous neurotrophic factors that promote nerve regeneration can replace the endogenous factors whose expression declines with time. But the profuse axonal outgrowth they provoke and the difficulties in their delivery hinder their efficacy. Brief (1 h) low-frequency (20 Hz) electrical stimulation (ES) proximal to the injury site promotes the expression of endogenous growth factors and, in turn, dramatically accelerates axon outgrowth and target reinnervation. The latter ES effect has been demonstrated in both rats and humans. A conditioning ES of intact nerve days prior to nerve injury increases axonal outgrowth and regeneration rate. Thereby, this form of ES is amenable for nerve transfer surgeries and end-to-side neurorrhaphies. However, additional surgery for applying the required electrodes may be a hurdle. ES is applicable in all surgeries with excellent outcomes.
“…For instance, in cases of axonotmesis with axonal continuity to the target organ evidenced by 1–2 motor units on EMG or present but markedly reduced amplitude motor or sensory responses on NCS, the optimal management strategy may involve serial electrodiagnostic assessments every 1–3 months to monitor nerve recovery ( 44 ). This close follow-up permits monitoring of the trajectory of nerve recovery clinically and electrodiagnostically to increase confidence in the likelihood of satisfactory spontaneous recovery or the need for surgical intervention ( 45 ).…”
“…In addition to the insights about extent of injury, approximate localization of injury, and which nerves would benefit from transfer, EDX serves as an invaluable tool to identify suitable donor nerves. Nerve transfer requires a healthy, expendable donor nerve, which typically serves a redundant or less crucial function ( 45 , 46 ). Needle EMG can confirm the health of the donor nerve and thus its suitability for transfer.…”
Peripheral nerve injuries are common and can have a devastating effect on physical, psychological, and socioeconomic wellbeing. Peripheral nerve transfers have become the standard of care for many types of peripheral nerve injury due to their superior outcomes relative to conventional techniques. As the indications for, and use of, nerve transfers expand, the importance of pre-operative assessment and post-operative optimization increases. There are two principal advantages of nerve transfers: (1) their ability to shorten the time to reinnervation of muscles undergoing denervation because of peripheral nerve injury; and (2) their specificity in ensuring proximal motor and sensory axons are directed towards appropriate motor and sensory targets. Compared to conventional nerve grafting, nerve transfers offer opportunities to reinnervate muscles affected by cervical spinal cord injury and to augment natural reinnervation potential for very proximal injuries. This article provides a narrative review of the current scientific knowledge and clinical understanding of nerve transfers including peripheral nerve injury assessment and pre- and post-operative electrodiagnostic testing, adjuvant therapies, and post-operative rehabilitation for optimizing nerve transfer outcomes.
“…The Oberlin's transfer, as first described in 2004 [459], is the classical example. This transfer to restore elbow flexion is one of several nerve transfers [459][460][461][462][463][464][465]. It is the suture a transected ulnar nerve fascicle that had supplied the flexor carpi ulnaris muscle, to the distal stump of the musculocutaneous nerve branch to biceps brachii muscle.…”
Section: G Conditioning Lesion and Conditioning Esmentioning
Injured peripheral nerves regenerate their axons in contrast to those in the central nervous system. However, functional recovery after surgical repair is often disappointing. The basis for the poor recovery is the progressive deterioration with time and distance, of the growth capacity of the neurons that lose their contact with targets (chronic axotomy) and the growth support of the chronically denervated Schwann cells (SC) in the distal nerve stumps. This is despite the retained capacity of chronically denervated and atrophic muscle to accept reinnervation. Progressive decline in regeneration associated genes in both axotomized neurons and denervated SCs accounts for the decline in regenerative success in association with silencing of neural activity in sensory neurons due to their disconnection from their sense organs and, in motoneurons due to loss of their synaptic contacts in the spinal cord. Whilst exogenous neurotrophic factors promote nerve regeneration, the profuse axonal outgrowth and difficulties in delivery are avoided by promoting their endogenous expression with brief (1 hour) low frequency (20Hz) electrical stimulation (ES) proximal to the injury site. ES accelerates axon outgrowth and in turn, target reinnervation in both animals and human subjects. Applying ES to intact nerve days prior to nerve injury, conditional ES (CES) increases axonal outgrowth and regeneration rate with the potential for application in nerve transfer surgeries and end-to-side neurorrhaphies. However, the additional surgery for applying CES electrodes may be a hurdle. ES is applicable in all surgeries with excellent outcomes.
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