Five Polyostotic Conditions That General Orthopedic Surgeons Should Recognize (or Should Not Miss)

Muthusamy, Saravanaraja; Conway, Sheila; Temple, H. Thomas

doi:10.1016/j.ocl.2014.04.004

Cited by 10 publications

(2 citation statements)

References 42 publications

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“…FD requires radiological follow-up since malignant transformation, although rare, is possible [11]. According to the literature, baseline and control TBBSs show intense metabolic activity [12,13].…”

Section: Discussionmentioning

confidence: 99%

Mazabraud's Syndrome: A Case Report and Up-To-Date Literature Review

Vescini

Falchetti

Tonelli

et al. 2019

EMIDDT

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Objective: Mazabraud's syndrome is a rare form of bone fibrous dysplasia associated with intramuscular myxomas. Fibrous dysplasia, is generally localized to pelvis and femur and it results in a fragile bone with deformities, pain, pathological fractures and functional impairment. Intramuscular myxomas, are rare benign mesenchymal neoplasms that exceptionally may evolve to malignant forms. Methods: This case report describes a 66-year-old woman with Mazabraud’s Syndrome (MS), characterized both by monostotic right femur fibrous dysplasia and by a solitary intramuscular myxoma at the right quadriceps muscle, that underwent a long-term treatment (4 years) with intravenous zoledronic acid. Results: Zoledronic acid therapy rapidly lowered bone pain together with a reduction of intramuscular myxoma volume, but did not affect the extension of fibrous dysplasia. No adverse effects have been observed during treatment. Conclusion: Highly active bisphosphonates are commonly used for the treatment of bone metabolic disorders and they are generally well tolerated. Zoledronic acid may represent a promising alternative to surgical intervention in MS, although its use in rare form of bone fibrous dysplasias is still controversial.

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Section: Discussionmentioning

confidence: 99%

Mazabraud's Syndrome: A Case Report and Up-To-Date Literature Review

Vescini

Falchetti

Tonelli

et al. 2019

EMIDDT

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“…Concerning findings include growth after skeletal maturity, thickness of the cartilage cap > 1 to 2 cm, and increasing pain. 28,29 Radiographs are often sufficient for the diagnosis of MHE and lesion characterization, showing sessile or pedunculated growths directed away from a joint or apophysis, with medullary continuity. Computed tomography (CT) may be required for surgical planning due to excellent bone visualization.…”

Section: Multiple Hereditary Exostosesmentioning

confidence: 99%

Skeletal Dysplasias: Radiologic Approach with Common and Notable Entities

Ngo

Thapa

Otjen

et al. 2018

Semin Musculoskelet Radiol

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Skeletal dysplasia is a heterogeneous group of abnormalities affecting growth and development of bone and cartilage characterized by disproportionate shortening of the limbs and/or spine. A systematic radiographic approach combined with pertinent clinical details can help guide specific genetic testing and treatment. We provide a discussion and examples of a few common and notable skeletal dysplasias to help familiarize general, pediatric, and musculoskeletal radiologists who do not commonly encounter children with these entities in their daily practices.

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McCune-Albright Syndrome

Chen¹

2015

Atlas of Genetic Diagnosis and Counseling

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Five Polyostotic Conditions That General Orthopedic Surgeons Should Recognize (or Should Not Miss)

Cited by 10 publications

References 42 publications

Mazabraud's Syndrome: A Case Report and Up-To-Date Literature Review

Mazabraud's Syndrome: A Case Report and Up-To-Date Literature Review

Skeletal Dysplasias: Radiologic Approach with Common and Notable Entities

McCune-Albright Syndrome

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