Five Functional Aspects of the Epidermal Barrier

Lefèvre‐Utile, Alain; Braun, C.; Haftek, Marek; Aubin, F.

doi:10.3390/ijms222111676

Cited by 69 publications

(81 citation statements)

References 79 publications

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“…It plays a crucial role in maintaining the barrier function of the skin. It is composed of corneocytes (brick) surrounded by a lipid matrix (mortar) [56]. Skin lipid peroxidation can be occurred by various mechanisms, especially free radicals.…”

Section: Antioxidant Activity Assaymentioning

confidence: 99%

Phytochemical Analysis and Antioxidant, Antimicrobial, and Antiaging Activities of Ethanolic Seed Extracts of Four Mucuna Species

et al. 2022

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The investigation into promising botanical materials for natural cosmetics is expanding due to environmental and health awareness. Here, we aimed to evaluate the phytochemical substances and the potential skin-related pharmacological activities of four Mucuna seeds, namely M. gigantea (Willd.) DC. (MGG), M. interrupta Gagnep. (MIT), M. monosperma Wight (MMM), and M. pruriens (L.) DC. (MPR), belonging to the Fabaceae family. In methodology, the Mucuna seeds were authenticated using morphological and molecular approaches. L-DOPA, phenolics, and flavonoid content, incorporated with HPLC and GC–MS fingerprinting analyses, were determined. Then, skin-related antimicrobial, antioxidant, and antiaging activities were determined. The results revealed that MPR showed the highest L-DOPA content (75.94 mg/100 mg extract), whereas MGG exhibited the highest phenolic and flavonoid content (56.73 ± 0.62 mg gallic/g extract and 1030.11 ± 3.97 mg quercetin/g extract, respectively). Only MMM and MPR could inhibit all of S. aureus, S. epidermidis, and C. albicans, but no sample could inhibit C. acnes. Furthermore, all samples demonstrated antioxidant activity. Interestingly, all Mucuna samples exhibited strong collagenase, elastase, and hyaluronidase inhibitory activities. We conclude that the ethanolic extracts of four Mucuna seeds are probably advantageous in the development of skincare cosmeceutical products.

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Section: Antioxidant Activity Assaymentioning

confidence: 99%

Phytochemical Analysis and Antioxidant, Antimicrobial, and Antiaging Activities of Ethanolic Seed Extracts of Four Mucuna Species

et al. 2022

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“…Epidermis is a complex and extended human tissue and provides a natural barrier which hampers bacterial systemic infections as well as the passage of toxic xenobiotics and molecules. [1] However, epidermis anatomy and physiology decreased the dermal and transdermal efficacy of different drugs, thus significantly limiting the treatment of cutaneous diseases, such as local inflammation. To overcome these drawbacks, nanocarriers delivering bioactive molecules have been studied and their physicochemical properties were tailored to overcome stratum corneum-epidermis and deep penetrate in the epidermis and derma.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multidrug Idebenone/Naproxen Co‐loaded Aspasomes for Significant in vivo Anti‐inflammatory Activity

et al. 2022

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The use of proper nanocarriers for dermal and transdermal delivery of anti-inflammatory drugs recently gained several attentions in the scientific community because they pass intact and accumulate payloads in the deepest layers of skin tissue. Ascorbyl palmitate-based vesicles (aspasomes) can be considered a promising nanocarrier for dermal and transdermal delivery due to their skin whitening properties and suitable delivery of payloads through the skin. The aim of this study was the synthesis of multidrug Idebenone/naproxen co-loaded aspasomes for the development of an effective anti-inflamma-tory nanomedicine. Aspasomes had suitable physicochemical properties and were safe in vivo if topically applied on human healthy volunteers. Idebenone/naproxen co-loaded aspasomes demonstrated an increased therapeutic efficacy of payloads compared to the commercially available Naprosyn® gel, with a rapid decrease of chemical-induced erythema on human volunteers. These promising results strongly suggested a potential application of Idebenone/naproxen multidrug aspasomes for the development of an effective skin anti-inflammatory therapy.

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“…The SC is usually described as a ‘bricks and mortar’ structure in which the protein enriched, flattened corneocytes (dead keratinocytes lacking vital cellular organelles) are the ‘bricks’, and the lipid-rich matrix in which they are embedded is the ‘mortar’ [ 1 ]. This lipid matrix predominantly contains ceramides (40–50%), cholesterol (25%) and free fatty acids (10–15%) [ 2 , 3 , 4 , 5 ]. These three major classes of lipids within the SC are biophysically and biochemically distinct from other conventional eukaryotic membrane constituents (e.g., glycerolipids, sphingolipids, sterols) that are involved in the structural and functional landscape of the cell membrane’s lipid bilayers [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Skin Cleansing without or with Compromise: Soaps and Syndets

Mijaljica¹,

Spada²,

Harrison³

2022

Molecules

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Products designed to cleanse the skin commonly do so through surfactant action, which leads to the lowering of the surface tension of the skin to facilitate the removal of dirt from its surface. Skin cleansers generally come in one of two types: soap-based and synthetic detergents, or syndets. While the latter can effectively maintain the native skin structure, function and integrity, the former tends to negatively affect the skin by causing barrier disruption, lipid dissolution and pH alteration. Despite this, soap is still often preferred, possibly due to the negative connotations around anything that is not perceived as ‘natural’. It is, therefore, important that the science behind cleansers, especially those designed for the maintenance of healthy skin and the management of common skin conditions such as eczema, be understood by both formulators and end-users. Here, we carefully weigh the advantages and disadvantages of the different types of surfactant—the key ingredient(s) in skin cleansers—and provide insight into surfactants’ physicochemical properties, biological activity and potential effects. Fine-tuning of the complex characteristics of surfactants can successfully lead to an ‘optimal’ skin cleanser that can simultaneously be milder in nature, highly effective and beneficial, and offer minimal skin interference and environmental impact.

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Five Functional Aspects of the Epidermal Barrier

Cited by 69 publications

References 79 publications

Phytochemical Analysis and Antioxidant, Antimicrobial, and Antiaging Activities of Ethanolic Seed Extracts of Four Mucuna Species

Phytochemical Analysis and Antioxidant, Antimicrobial, and Antiaging Activities of Ethanolic Seed Extracts of Four Mucuna Species

Multidrug Idebenone/Naproxen Co‐loaded Aspasomes for Significant in vivo Anti‐inflammatory Activity

Skin Cleansing without or with Compromise: Soaps and Syndets

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