Five-day cefdinir course vs. ten-day cefprozil course for treatment of acute otitis media

Abstract

A short course 5-day regimen of cefdinir was as clinically effective and well-tolerated as a 10-day regimen of cefprozil in the treatment of nonrefractory AOM.

Study of nasopharyngeal bacterial flora. Second report. Variations in nasopharyngeal bacterial flora in children aged 6 years or younger when administered antimicrobial agents. Part 1

“…[41][42][43][44][45][46][47][48][49] In all of these reports, clinical efficacy was judged to be around 80%, which is not significant. However, it has been reported that within a confidence limit of 95%, oral cephems, macrolides, and CTRX are slightly less clinically effective than AMPC and CVA/AMPC, and depending on the method of use they are clearly clinically less effective.…”

Comparison of the effectiveness and safety of cefpodoxime and ciprofloxacin in acute exacerbation of chronic suppurative otitis media: A randomized, open-labeled, phase IV clinical trial

“…Very few studies have evaluated the effectiveness of oral third-generation cephalosporins in patients with otitis media. [1314] A study reported by Block et al . [13] compared the effectiveness of cefdinir with cefprozil, and the results showed that the overall clinical cure rate with cefdinir was 80% versus 82.5% with cefprozil in the treatment of pediatric acute otitis media.…”

“…[1314] A study reported by Block et al . [13] compared the effectiveness of cefdinir with cefprozil, and the results showed that the overall clinical cure rate with cefdinir was 80% versus 82.5% with cefprozil in the treatment of pediatric acute otitis media. Another study by Kafetzis showed that the overall clinical cure rate with cefixime was 85% in patients with acute otitis media.…”

Study of nasopharyngeal bacterial flora. Second report. Variations in nasopharyngeal bacterial flora in children aged 6 years or younger when administered antimicrobial agents. Part 2

“…As mentioned before, many comparative clinical studies involved doses of AMPC or CVA/AMPC for a period of 10 days. 31,[64][65][66][67][68][69] This could be based on clinical experience of recurrence and relapse. Pichichero et al 70 observed 3 groups of AOM patients receiving doses of antimicrobial agents for 5, 7, and 10 days, respectively.…”