Five‐Coordinate Platinum(II) Compounds as Potential Anticancer Agents

Abstract

Five‐coordinate platinum(II) complexes represent a minority compared to the well‐known class of square‐planar species. However, since the first appearances in the literature, their general properties have attracted much interest. In particular, their potential to act as anticancer agents has been considered, and several studies have demonstrated their effectiveness as pro‐drugs. The review traces the progress of these investigations over time and the subsequent refinements in the structures. It also reports their synthesis, general properties, cytotoxic activity and ability to interact with biological macromolecules.

Metallodrugs: Mechanisms of Action, Molecular Targets and Biological Activity

“…The square-planar species were more stable and less cytotoxic than the corresponding 5C compounds, but they exhibited a certain selectivity. These results suggest that the stability of Pt compounds is important for preserving their performance as cytotoxic agents, and support the hypothesis that coordinative saturation can be a point in favor of their biological action [ 15 ].…”

NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments

“…The discovery of cisplatin in the 1960s triggered, firstly, the synthesis of new platinum compounds bearing biological activity, and then the preparation of complexes with other metals [ 39 , 40 ]. More recently, researchers have pursued complexes containing active drugs as ligands, since it has been proved that this approach could be a suitable strategy for developing new and more efficacious pharmacological compounds, together with less toxic effects when compared to the parent drugs [ 41 , 42 , 43 , 44 , 45 ]. Although some metal complexes received attention due to the anticancer activity of cisplatin and its derivatives, in many cases they possess other different and promising biological activities.…”

In Vitro Anticancer Activity of Nanoformulated Mono‐ and Di‐nuclear Pt Compounds

“…A central Pt(II/IV) coordinated by specific ligand types can achieve nucleic acid selectivity and apoptosis [4b,21] . A well‐known example is oxaliplatin that can induce immunogenic cell death (ICD) in the treatment of colon cancer, while cisplatin and other clinically adapted platinum drugs fail to do so [4e,22] .…”