In Vitro Anticancer Activity of Nanoformulated Mono‐ and Di‐nuclear Pt Compounds

Abstract

Nanoformulations of mononuclear Pt complexes cis-PtCl 2 (PPh 3 ) 2 (1), [Pt(PPh 3 ) 2 (LÀ Cys)] • H 2 O (3, LÀ Cys = L-cysteinate), trans-PtCl 2 (PPh 2 PhNMe 2 ) 2 (4; PPh 2 PhNMe 2 = 4-(dimethylamine)triphenylphosphine), trans-PtI 2 (PPh 2 PhNMe 2 ) 2 ( 5) and dinuclear Pt cluster Pt 2 (μ-S) 2 (PPh 3 ) 4 (2) have comparable cytotoxicity to cisplatin against murine melanoma cell line B16F10. Masking of these discrete molecular entities within the hydrophobic core of Pluronic® F-127 significantly boosted their solubility and stability, ensuring efficient cellular uptake, giving in vitro IC 50 values in the range of 0.87-11.23 μM. These results highlight the potential therapeutic value of Pt complexes featuring stable PtÀ P bonds in nanocomposite formulations with biocompatible amphiphilic polymers.

ZIF-8 with cationic defects toward efficient 125I2 uptake for in vitro radiotherapy of colon cancer

“…PEG) enhances cell permeability and retention (EPR). 4 MOF assembly dynamics can be fine-tuned using modulators to generate nanoscale metal–organic frameworks (NMOFs) with desirable size and shape for selected applications. 5 There is also a trend for using cell membranes to coat drug-loaded NMOFs to enhance homologous targeting.…”