Five-coordinate cobalt(II) complexes of tris(2-pyridylmethyl)amine (TPA): Synthesis, structural and magnetic characterization of a terephthalato-bridged dinuclear cobalt(II) complex

Effect of the central metal ion on the cleavage of DNA by [M(TPA)Cl]ClO4 complexes (M=CoII, CuII and ZnII, TPA=tris(2-pyridylmethyl)amine): An efficient artificial nuclease for DNA cleavage

“…The ligation products were then electrophoresed, stained and imaged. (3)) where a predominant tetrahedral geometry attributed to [Co(TPA)] 2+ ion was detected in solution [40]. This clearly reveals the very weak coordination of the aqua water molecule to the central Co II ion in 1.…”

“…The ligand tris(2-pyridylmethyl)amine (TPA) was synthesized following the procedures described by Anderegg and modified by Karlin's group, and characterized as recently reported [39]. The complex [Co(TPA)Cl]ClO 4 (1) was synthesized using the published procedures [40]. Infrared spectra were recorded on a JASCO FT/IR-480 plus spectrometer as KBr pellets.…”

“…(3) distorted to tetrahedral [40,45], where the axial aqua ligand is becoming weakly bound to Co II ion. This may increase the rate of adduct formation of Co II -TPA-DNA and hence its rapid cleavage of DNA compared to [Cu(TPA)(H 2 O)] 2+ which reacts slowly with DNA.…”

Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid

“…The mononuclear copper(II) complex of 2-[bis(2-pyridylmethyl)amino] propanic acid was reported to inhibit the proliferation of cancer cells [7]. Fe(III) and Co(II) complexes containing polydentate nitrogen donor ligands of [bis(2-pyridylmethyl)amine (DPA) and tris(2-pyridylmethyl)amine (TPA) have been the subject of considerable interest due to their use as model systems for biologically important molecules [8,9]. Iron complexes have long been used for treating various diseases, and cobalt complexes have been investigated as potential hypoxia-activated prodrugs [10].…”

Synthesis and crystal structures of terephthalato-bridged macrocyclic nickel(II) complexes with cis configurations

“…Many dinuclear complexes where the metal atoms are bridged by extended dicarboxylato ligands such as l-terephthalate, l-oxalate, l-butene dicarboxylate have been reported to date [10][11][12][13][14][15][16][17][18][19][20].…”