Synthesis, DNA interaction and antitumor activities of cobalt(II) and iron(III) complexes of 2-[bis(2-pyridylmethyl)amino] propanic acid

Abstract

Three complexes with 2-[bis(2-pyridylmethyl)-amino] propanic acid (Adpa) were synthesized and characterized. The crystal structure of [(Adpa)CoCl] (1) shows that the cobalt(II) atom is coordinated by three N atoms, one oxygen atom from the Adpa ligand and one chloride, forming a distorted trigonal bipyramidal geometry. The fluorescence titration data indicate the interactions of ct-DNA with complexes [(Adpa)FeCl 2 ] (2) and [(Adpa)-Fe(H 2 O) 2 ] (3) are exothermic, but binding of complex (1) with ct-DNA is endothermic. The inhibiting activities of the three complexes on the cancer cells (Mcf-7, Eca-109, A549 and Hela) follow the order: (3) [ (2) ) (1), which is in correlation with their DNA-binding properties.

Dual Role of Au nanoparticles in the Catalytic Formation of an Amorphous Polynuclear Peroxo Complex and Surface Enhanced Resonance Raman Scattering

“…The observations also indicated that the 2-PA molecule-in the complex that was the unit of the polymer-might have been attached to Au surface through pyridine-N whereas aminomethyl-N participated in complexation. It is therefore plausible that 2-PA molecule acted as monodentate ligand in this complexation reaction that is different from the reported literature, [10,14,15,18] suggesting the flexidentate nature of the ligand.…”

“…In summary, literature reports [10,14,15,18] suggest that the reaction between Co(II) and 2‐PA leads to the formation of a chelate complex. However, the current work‐ based on SERRS and mass spectrometric studies‐ revealed that in basic media Co(II) reacted with 2‐PA to produce bridged polynuclear peroxo complex via sigmoidal kinetics, where 2‐PA molecule acted as a monodentate ligand even in the presence of the Au nanoparticles.…”

“…Among others, 2‐PA based cobalt complexes have received great recent interests in the synthesis of metal complexes having open coordination sites or to mimic non‐heme dioxygenase [10] . Cobalt complexes with 2‐PA moieties are deemed important for their potential antitumor activities [10,11] . In addition, they have been considered as hypoxia‐activated prodrugs [12] .…”

“…Thus, understanding of the structure and function of the central complexes is key to the knowledge of the workings of the co‐enzymes. Among others, 2‐PA based cobalt complexes have received great recent interests in the synthesis of metal complexes having open coordination sites or to mimic non‐heme dioxygenase [10] . Cobalt complexes with 2‐PA moieties are deemed important for their potential antitumor activities [10,11] .…”

“…[10] Cobalt complexes with 2-PA moieties are deemed important for their potential antitumor activities. [10,11] In addition, they have been considered as hypoxia-activated prodrugs. [12] Biological activities of Schiff-base complex between cobalt and 2-PA are extensively studied in coordination chemistry because of the enhanced activities as compared to non-Schiff-base complex.…”