Five cases of coexistent primary ocular and cutaneous melanoma

Ruthenium Brachytherapy for Uveal Melanoma, 1979–2003Survival and Functional Outcomes in the Swedish Population

“…A previous Swedish case-control study was unable to detect a higher frequency of uveal naevi in patients with dysplastic naevus syndrome 134 Reports of co-existing atypical naevi 135 , cutaneous melanoma and ocular melanoma in probands and their families exist in the literature, often as case reports or case series 130,[136][137][138][139][140][141][142] or in small case-control studies 143,144 with varying definitions of atypical naevi. Bataille 138 examined 207 eye melanoma patients, of which 5 had cutaneous melanoma, in three cases combined with DNS (expected cases of cutaneous melanoma = 0.4).…”

Coexistent Primary Choroidal and Cutaneous Melanoma

“…The development of primary choroidal and cutaneous malignant melanoma in the same patient is rare, with only 8 cases described in the literature (1 -3). In contrast, the occurrence of primary cutaneous and choroidal melanoma in association with the atypical mole syndrome has been documented by a number of authors (2). We describe here the case of a 71-year-old man who presented initially with deterioration in the vision of his left eye secondary to a retinal detatchment (Fig.…”

Genetics of melanoma

“…23 In the UK there also appears to be evidence of an association between choroidal or conjunctival melanoma and cutaneous melanoma. 24 ' 25 Other authors, however, have been unable to confirm this association. 26 The AMS phenotype in the general population and risk of melanoma The presence of abnormal melanocytic naevi has been established as the most potent risk factor for melanoma 20 in case control studies of melanoma in the general population.…”