“…Genomic regions that exhibit losses of heterozygosity (LOH) and therefore suggest the presence of tumour suppressor genes in sporadic melanomas, have been identified, among others, at chromosomes 6q22-27 (Albino et al, 1994) and 11q22-23 (Robertson et al, 1999). Moreover, LOHs at chromosome 10 occur in 30 -60% of both early-and advanced-stage tumours (Newton, 1994;Bastian et al, 1998) and are an indicator of a poor clinical prognosis (Healy et al, 1998). Segmental deletions were cytogenetically localized to 10q (Richmond et al, 1986;Parmiter et al, 1988;Isshiki et al, 1993;Indsto et al, 1998) and subsequently narrowed by studies of LOH to 10q22-qter (Isshiki et al, 1993;Herbst et al, 1994;Walker et al, 1995;Healy et al, 1996).…”