We have studied the effect of spin-orbital coupling (SOC) on electronic transport properties of the thermoelectric material -K2Bi8Se13 via magnetoresistance (MR) measurements. We found that the strong SOC in this material results in weak antilocalization (WAL) effect, which can be well described by the three-dimensional weak localization model. The phase coherence length extracted from theoretical fitting exhibits a power-law temperature dependence with an exponent around 2.1, indicating that the electron phase dephasing is governed by electron -transverse phonon interactions. Like in topological insulators, the WAL effect in -K 2 Bi 8 Se 13 can be quenched by magnetic impurities (Mn) but is robust against nonmagnetic impurities (Te). Although our magnetotransport studies do not provide any evidences for topological surface states, our analyses suggest that SOC plays an important role in determining thermoelectric properties of -K2Bi8Se13.