Fish TNF and TNF receptors

Li, Yaoguo; Xiao, Tiaoyi; Zou, Jun

doi:10.1007/s11427-020-1712-4

Cited by 37 publications

(9 citation statements)

References 240 publications

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Section: Adipokinesmentioning

confidence: 99%

“…TNFα receptors, TNFR1 and TNFR2, have been described for several fish species ( 129 ). The functions of TNFR1 are, among others, related to apoptosis or cellular death while TNFR2 is involved in the promotion of cell survival ( 129 ). tnfr1 is expressed in many tissues, but tnfr2 is more tissue specific, limited to immune, endothelial, microglia and nerve cells ( 129 ).…”

Section: Adipokinesmentioning

confidence: 99%

“…TNFα has a clear paracrine and/or autocrine role within adipose tissue ( 17 ). In mammals and fish, TFNα promotes adipocyte lipolysis, modulates lipogenesis, and glucose transport and inhibits pre-adipocytes proliferation ( 129 , 132 ). It can also interact with other cytokines and vice versa ( 115 ).…”

Section: Adipokinesmentioning

confidence: 99%

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Recent advances in the crosstalk between adipose, muscle and bone tissues in fish

et al. 2023

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Control of tissue metabolism and growth involves interactions between organs, tissues, and cell types, mediated by cytokines or direct communication through cellular exchanges. Indeed, over the past decades, many peptides produced by adipose tissue, skeletal muscle and bone named adipokines, myokines and osteokines respectively, have been identified in mammals playing key roles in organ/tissue development and function. Some of them are released into the circulation acting as classical hormones, but they can also act locally showing autocrine/paracrine effects. In recent years, some of these cytokines have been identified in fish models of biomedical or agronomic interest. In this review, we will present their state of the art focusing on local actions and inter-tissue effects. Adipokines reported in fish adipocytes include adiponectin and leptin among others. We will focus on their structure characteristics, gene expression, receptors, and effects, in the adipose tissue itself, mainly regulating cell differentiation and metabolism, but in muscle and bone as target tissues too. Moreover, lipid metabolites, named lipokines, can also act as signaling molecules regulating metabolic homeostasis. Regarding myokines, the best documented in fish are myostatin and the insulin-like growth factors. This review summarizes their characteristics at a molecular level, and describes both, autocrine effects and interactions with adipose tissue and bone. Nonetheless, our understanding of the functions and mechanisms of action of many of these cytokines is still largely incomplete in fish, especially concerning osteokines (i.e., osteocalcin), whose potential cross talking roles remain to be elucidated. Furthermore, by using selective breeding or genetic tools, the formation of a specific tissue can be altered, highlighting the consequences on other tissues, and allowing the identification of communication signals. The specific effects of identified cytokines validated through in vitro models or in vivo trials will be described. Moreover, future scientific fronts (i.e., exosomes) and tools (i.e., co-cultures, organoids) for a better understanding of inter-organ crosstalk in fish will also be presented. As a final consideration, further identification of molecules involved in inter-tissue communication will open new avenues of knowledge in the control of fish homeostasis, as well as possible strategies to be applied in aquaculture or biomedicine.

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Section: Adipokinesmentioning

confidence: 99%

Section: Adipokinesmentioning

confidence: 99%

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Recent advances in the crosstalk between adipose, muscle and bone tissues in fish

et al. 2023

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“…Lysozymes, complement and phosphatases are known to be as important immune factors, playing a central role in the innate immune response for protection against microbial pathogens in fish (Cain & Swan, 2010; Trichet, 2010). Tnfα is one type of cytokines mainly produced by macrophages, and Fish Tnfα augments the respiratory burst response, upholds the proliferation and development of T cells in fish thymus and enhances migration of immune cells, which plays a critical role in regulating the inflammatory process, although excess Tnfα is detrimental to the host (Li et al, 2020). The above results suggest that dietary enriched EPA and DHA, and especially EPA, contribute to promoting the intestinal immune response in T. ovatus .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of different dietary n ‐3 lc‐pufa on the growth, intestinal health and microbiota profile of golden pompano ( Trachinotus ovatus )

et al. 2021

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The omega‐3 long‐chain polyunsaturated fatty acids (n‐3 LC‐PUFA), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are essential fatty acids for marine fish. This study aimed to evaluate different dietary n‐3 LC‐PUFA on the growth, intestinal health and microbiome in carnivorous marine fish Trachinotus ovatus. Three diets, respectively, supplemented with fish oil, EPA‐enriched oil and DHA‐enriched oil were fed juvenile T. ovatus for 10 weeks. The results showed that the three groups showed no difference in the growth, histology and digestive enzyme activities of anterior intestine. Moreover, the intestinal ACP and ALP activities and tnfɑ mRNA level were increased in the EPA‐enriched group, whereas the serum diamine oxidase activity and intestinal lysozyme activity and malondialdehyde content were decreased in both EPA‐ and DHA‐enriched groups. Meanwhile, these two diets also down‐regulated the mRNA expression of Mucin 2, Mucin 13, hes1‐b, Krueppel‐like factor 4 and Occludin, and up‐regulated the zonula occludens‐1 mRNA levels in intestine. Moreover, the two groups significantly decreased the intestinal Vibrio abundance and increased the probiotic proportions, especially in the EPA‐enriched group. These results indicate dietary n‐3 LC‐PUFA would facilitate normal intestinal function and probiotics profiles of T. ovatus, and the EPA‐enriched group appears to be more positive.

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“…Teleosts contain over 26,000 described species, economically important to humans. Also they are crucial for evolutionary biology (Li et al, 2021). Up to date, type III IFN is not reported in teleosts.…”

mentioning

confidence: 99%

The discovery of type IV interferon system revolutionizes interferon family and opens up a new frontier in jawed vertebrate immune defense

2022

Sci. China Life Sci.

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Fish TNF and TNF receptors

Cited by 37 publications

References 240 publications

Recent advances in the crosstalk between adipose, muscle and bone tissues in fish

Recent advances in the crosstalk between adipose, muscle and bone tissues in fish

Evaluation of different dietary n ‐3 lc‐pufa on the growth, intestinal health and microbiota profile of golden pompano ( Trachinotus ovatus )

The discovery of type IV interferon system revolutionizes interferon family and opens up a new frontier in jawed vertebrate immune defense

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