Fish-oil supplementation enhances the effects of strength training in elderly women

Rodacki, Cintia de Lourdes Nahhas; Rodacki, André Luíz Félix; Pereira, Gléber; Naliwaiko, Katya; Coelho, Isabela; Pequito, Daniele; Fernandes, L C

doi:10.3945/ajcn.111.021915

Cited by 241 publications

(286 citation statements)

References 32 publications

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“…While we originally hypothesized that anti-inflammatory effects of v-3 supplementation would be the underlying mechanism, we did not observe any statistically significant changes in systemic inflammatory markers, such as hs-CRP and IL-6, although levels of several other chemokines were improved in response to the intervention as previously reported (9). It is possible that the effects of v-3 fatty acids on protein turnover are independent of its effects on inflammatory pathways, as suggested in previous studies (4,20). Since we hypothesized that the beneficial effects would be mediated though inflammatory pathways, lower CRP concentrations in the intervention arm at baseline could have led to a reduced effect of fish oil supplementation on protein breakdown.…”

Section: Discussionsupporting

confidence: 62%

High Dose Omega-3 Fatty Acid Administration and Skeletal Muscle Protein Turnover in Maintenance Hemodialysis Patients

Deger

Hung

Ellis³

et al. 2016

CJASN

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Background and Objectives Protein energy wasting and systemic inflammation are prevalent in maintenance hemodialysis (MHD) patients. Omega-3 (v-3) fatty acids have anti-inflammatory properties and have been shown to improve protein homeostasis. We hypothesized that administration of high-dose (2.9 g/d) v-3 would be associated with decreased muscle protein breakdown in MHD patients with systemic inflammation.Design, setting, participants & measurements This is a substudy from a randomized, placebo-controlled study (NCT00655525). Patients were recruited between September 2008 and June 2011. Primary inclusion criteria included signs of chronic inflammation (average C-reactive protein of $5 mg/L over three consecutive measurements), lack of active infectious or inflammatory disease, no hospitalization within 1 month prior to the study, and not receiving steroids (.5 mg/d) and/or immunosuppressive agents. The primary outcomes were forearm muscle and whole body protein breakdown and synthesis before and after the intervention. The patients received v-3 (n=11) versus placebo (n=9) for 12 weeks. Analysis of covariance was used to compare outcome variables at 12 weeks. Models were adjusted for a propensity score that was derived from age, sex, race, baseline high sensitivity C-reactive protein, diabetes mellitus, and fat mass because the groups were not balanced for several characteristics.Results Compared with placebo, v-3 supplementation was significantly associated with decreased muscle protein breakdown at 12 weeks (231, [interquartile range, 298-213] versus 26 [interquartile range, 13-87] mg/100 ml per min; P=0.01), which remained significant after multivariate adjustment (246, [95% confidence interval, 2102 to 21] mg/100 ml per min). v-3 Supplementation resulted in decreased forearm muscle protein synthesis while the rate in the placebo group increased; however, there is no longer a statistically significant difference in skeletal muscle protein synthesis or in net protein balance after multivariate adjustment. There was no statistically significant effect of v-3 supplementation on whole body protein synthesis or breakdown.Conclusions High-dose v-3 supplementation over 12 weeks in MHD patients with systemic inflammation was associated with attenuation of forearm muscle protein breakdown but did not influence skeletal muscle protein synthesis, skeletal muscle net protein balance or any component of the whole-body protein balance. These results should be interpreted cautiously given the imbalance in the two groups and the short duration of the intervention.

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Section: Discussionsupporting

confidence: 62%

High Dose Omega-3 Fatty Acid Administration and Skeletal Muscle Protein Turnover in Maintenance Hemodialysis Patients

Deger

Hung

Ellis³

et al. 2016

CJASN

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“…mostraron un efecto potenciador sobre la fuerza muscular máxima al combinar suplementación de O3 y entrenamiento de resistencia muscular durante 12 semanas. Ellos atribuyeron el aumento de fuerza muscular a los efectos positivos del O3 sobre la permeabilidad de membrana y aumentos en la sensibilidad de acetilcolina (23). La fluidez de membrana aumentaría la velocidad de conducción y facilitaría el impulso nervioso, favoreciendo la contracción muscular.…”

Section: Efectos De La Suplementación De Omega-3 Y Entrenamiento De Iunclassified

Efectos de la suplementación de omega-3 y entrenamiento de intervalos de alta intensidad en el rendimiento físico, presión arterial y composición corporal en individuos sedentarios con sobrepeso

et al. 2016

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Zbinden-Foncea H. Efectos de la suplementación de omega-3 y entrenamiento de intervalos de alta intensidad en el rendimiento físico, presión arterial y composición corporal en individuos sedentarios con sobrepeso. Nutr Hosp 2016;33:848-855 DOI: http://dx.doi.org/10.20960/nh.380Efectos de la suplementación de omega-3 y entrenamiento de intervalos de alta intensidad en el rendimiento físico, presión arterial y composición corporal en individuos sedentarios con sobrepeso Effects of omega-3 supplementation and high intensity interval training in physical performance, blood pressure and body composition in overweight individuals AbstractBackground: High Intensity Interval Training (HIIT) has shown to increase oxidative capacity and maximum oxygen consumption (VO 2max ) in different populations. On the other side, the consumption of Omega-3 fatty acids (O3) has positive effects on oxidative metabolism. Objective: To observe the effects of a combination of HIIT and O3 supplementation on parameters of physical performance, blood pressure, and body composition in overweight adults. Methods: 28 young, non-active, overweight individuals (22 ± 4 years; BMI = 25.8 ± 2.4 kg/m

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“…Another study found grip strength was positively related to fish intake in olderaged men and women and an intervention found fish oils enhanced strength training in men (140,141) .…”

Section: Biological and Behavioural Factors Affecting Loss Of Muscle mentioning

confidence: 99%

Nutritional influences on age-related skeletal muscle loss

2013

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Age-related muscle loss impacts on whole-body metabolism and leads to frailty and sarcopenia, which are risk factors for fractures and mortality. Although nutrients are integral to muscle metabolism the relationship between nutrition and muscle loss has only been extensively investigated for protein and amino acids. The objective of the present paper is to describe other aspects of nutrition and their association with skeletal muscle mass. Mechanisms for muscle loss relate to imbalance in protein turnover with a number of anabolic pathways of which the mechanistic TOR pathway and the IGF-1-Akt-FoxO pathways are the most characterised.

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Fish-oil supplementation enhances the effects of strength training in elderly women

Abstract: Strength training increased muscle strength in elderly women. The inclusion of FO supplementation caused greater improvements in muscle strength and functional capacity.

Cited by 241 publications

References 32 publications

High Dose Omega-3 Fatty Acid Administration and Skeletal Muscle Protein Turnover in Maintenance Hemodialysis Patients

High Dose Omega-3 Fatty Acid Administration and Skeletal Muscle Protein Turnover in Maintenance Hemodialysis Patients

Efectos de la suplementación de omega-3 y entrenamiento de intervalos de alta intensidad en el rendimiento físico, presión arterial y composición corporal en individuos sedentarios con sobrepeso

Nutritional influences on age-related skeletal muscle loss

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